GNA12

 

Full name: G protein subunit alpha 12 Alias Symbol: gep
Type: protein-coding gene Cytoband: 7p22.3-p22.2
Entrez ID: 2768 HGNC ID: HGNC:4380 Ensembl Gene: ENSG00000146535 OMIM ID: 604394
Drug and gene relationship at DGIdb
Screen Evidence:

 

GNA12 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton

 

Expression of GNA12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNA12 2768 224681_at 0.8394 0.1411
GSE20347 GNA12 2768 221737_at 0.7471 0.0000
GSE23400 GNA12 2768 221737_at 0.3189 0.0000
GSE26886 GNA12 2768 224681_at 1.3441 0.0000
GSE29001 GNA12 2768 221737_at 1.5645 0.0000
GSE38129 GNA12 2768 221737_at 0.6098 0.0000
GSE45670 GNA12 2768 224681_at 0.5196 0.0838
GSE53622 GNA12 2768 61828 1.1997 0.0000
GSE53624 GNA12 2768 61828 1.5016 0.0000
GSE63941 GNA12 2768 224681_at -0.7830 0.1198
GSE77861 GNA12 2768 224681_at 0.8666 0.0127
GSE97050 GNA12 2768 A_23_P215265 0.5729 0.1657
SRP007169 GNA12 2768 RNAseq 3.4890 0.0000
SRP008496 GNA12 2768 RNAseq 3.7944 0.0000
SRP064894 GNA12 2768 RNAseq 1.2578 0.0000
SRP133303 GNA12 2768 RNAseq 1.3961 0.0000
SRP159526 GNA12 2768 RNAseq 1.0618 0.0000
SRP193095 GNA12 2768 RNAseq 1.6914 0.0000
SRP219564 GNA12 2768 RNAseq 0.5106 0.3914
TCGA GNA12 2768 RNAseq 0.1011 0.0683

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by GNA12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNA12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNA12 2768 15 1 14
GSE20123 GNA12 2768 15 1 14
GSE43470 GNA12 2768 7 2 34
GSE46452 GNA12 2768 13 1 45
GSE47630 GNA12 2768 10 1 29
GSE54993 GNA12 2768 0 7 63
GSE54994 GNA12 2768 22 2 29
GSE60625 GNA12 2768 0 0 11
GSE74703 GNA12 2768 7 1 28
GSE74704 GNA12 2768 9 0 11
TCGA GNA12 2768 56 5 35

Total number of gains: 154; Total number of losses: 21; Total Number of normals: 313.  

 

Somatic mutations of GNA12:

 

Generating mutation plots.

 

Highly correlated genes for GNA12:

 

Showing top 20/1855 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNA12LRRC8C0.822214303
GNA12RAB340.815693303
GNA12FCGR3A0.808948303
GNA12CEP1700.802579303
GNA12FADS10.801602303
GNA12GALNT180.776641606
GNA12FNDC3B0.77571611011
GNA12GNG100.774508303
GNA12SPON20.773597303
GNA12PDIA50.77147303
GNA12GPX80.769235707
GNA12IKBIP0.76788606
GNA12PYCR20.752155303
GNA12LPCAT10.74988311011
GNA12FMNL20.748117707
GNA12RAB300.745854303
GNA12LRP120.74226912012
GNA12SLC35B20.740988303
GNA12MMD0.73803912011
GNA12ARPC1B0.73697811011

For details and further investigation, click here