PPP2R2A

 

Full name: protein phosphatase 2 regulatory subunit Balpha Alias Symbol: PR52A|PR55A|B55A|PR55alpha|B55alpha
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 5520 HGNC ID: HGNC:9304 Ensembl Gene: ENSG00000221914 OMIM ID: 604941
Drug and gene relationship at DGIdb
Screen Evidence:

 

PPP2R2A involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04390Hippo signaling pathway
hsa04530Tight junction
hsa04728Dopaminergic synapse
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C

 

Expression of PPP2R2A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP2R2A 5520 202313_at -0.5229 0.2503
GSE20347 PPP2R2A 5520 202313_at -0.8085 0.0000
GSE23400 PPP2R2A 5520 202313_at -0.6622 0.0000
GSE26886 PPP2R2A 5520 202313_at -1.4432 0.0000
GSE29001 PPP2R2A 5520 202313_at -1.1061 0.0013
GSE38129 PPP2R2A 5520 202313_at -0.6420 0.0019
GSE45670 PPP2R2A 5520 202313_at -0.3665 0.0654
GSE53622 PPP2R2A 5520 37478 -0.6986 0.0000
GSE53624 PPP2R2A 5520 37478 -1.1258 0.0000
GSE63941 PPP2R2A 5520 202313_at 0.5381 0.2349
GSE77861 PPP2R2A 5520 202313_at -0.3881 0.1787
GSE97050 PPP2R2A 5520 A_23_P123539 -0.1631 0.6740
SRP007169 PPP2R2A 5520 RNAseq -1.9195 0.0000
SRP008496 PPP2R2A 5520 RNAseq -2.0293 0.0000
SRP064894 PPP2R2A 5520 RNAseq -1.4919 0.0000
SRP133303 PPP2R2A 5520 RNAseq -1.0642 0.0000
SRP159526 PPP2R2A 5520 RNAseq -1.3417 0.0000
SRP193095 PPP2R2A 5520 RNAseq -1.1254 0.0000
SRP219564 PPP2R2A 5520 RNAseq -1.4054 0.0017
TCGA PPP2R2A 5520 RNAseq 0.0690 0.2409

Upregulated datasets: 0; Downregulated datasets: 10.  

 

Survival by PPP2R2A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP2R2A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP2R2A 5520 4 12 14
GSE20123 PPP2R2A 5520 4 12 14
GSE43470 PPP2R2A 5520 4 7 32
GSE46452 PPP2R2A 5520 13 13 33
GSE47630 PPP2R2A 5520 10 8 22
GSE54993 PPP2R2A 5520 2 15 53
GSE54994 PPP2R2A 5520 9 16 28
GSE60625 PPP2R2A 5520 3 0 8
GSE74703 PPP2R2A 5520 4 6 26
GSE74704 PPP2R2A 5520 3 8 9
TCGA PPP2R2A 5520 14 44 38

Total number of gains: 70; Total number of losses: 141; Total Number of normals: 277.  

 

Somatic mutations of PPP2R2A:

 

Generating mutation plots.

 

Highly correlated genes for PPP2R2A:

 

Showing top 20/1462 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP2R2ASMAGP0.7764210010
PPP2R2ARAB11A0.76488411011
PPP2R2ASH3PXD2A-AS10.763264303
PPP2R2AULK30.757844707
PPP2R2ATMPRSS11E0.753478909
PPP2R2ATM7SF20.74200411011
PPP2R2AGLTP0.741398808
PPP2R2AACPP0.74139310010
PPP2R2AARHGAP270.740784707
PPP2R2ATRAPPC20.739399303
PPP2R2AMALL0.739141909
PPP2R2ASMIM50.737323606
PPP2R2AABHD50.73645810010
PPP2R2ASAMD50.736325606
PPP2R2ASCEL0.734171009
PPP2R2AVPS4B0.73383111010
PPP2R2ANLRX10.73281111010
PPP2R2ATMOD30.73235911010
PPP2R2ATHYN10.73092303
PPP2R2ACXCR20.72909211011

For details and further investigation, click here