| Full name: RAB2A, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q12.1-q12.2 | ||
| Entrez ID: 5862 | HGNC ID: HGNC:9763 | Ensembl Gene: ENSG00000104388 | OMIM ID: 179509 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RAB2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway |
Expression of RAB2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB2A | 5862 | 208731_at | -0.2966 | 0.3483 | |
| GSE20347 | RAB2A | 5862 | 208731_at | -0.6752 | 0.0001 | |
| GSE23400 | RAB2A | 5862 | 208731_at | -0.3300 | 0.0003 | |
| GSE26886 | RAB2A | 5862 | 208731_at | -1.1413 | 0.0000 | |
| GSE29001 | RAB2A | 5862 | 208731_at | -0.9004 | 0.0470 | |
| GSE38129 | RAB2A | 5862 | 208731_at | -0.5016 | 0.0011 | |
| GSE45670 | RAB2A | 5862 | 208731_at | -0.2643 | 0.0236 | |
| GSE53622 | RAB2A | 5862 | 25452 | -0.5180 | 0.0000 | |
| GSE53624 | RAB2A | 5862 | 25452 | -0.6644 | 0.0000 | |
| GSE63941 | RAB2A | 5862 | 208731_at | -1.1566 | 0.0105 | |
| GSE77861 | RAB2A | 5862 | 208734_x_at | -0.5224 | 0.1567 | |
| GSE97050 | RAB2A | 5862 | A_23_P340251 | -0.1845 | 0.5265 | |
| SRP007169 | RAB2A | 5862 | RNAseq | -2.2185 | 0.0000 | |
| SRP008496 | RAB2A | 5862 | RNAseq | -1.7658 | 0.0000 | |
| SRP064894 | RAB2A | 5862 | RNAseq | -0.4314 | 0.0129 | |
| SRP133303 | RAB2A | 5862 | RNAseq | -0.3030 | 0.0561 | |
| SRP159526 | RAB2A | 5862 | RNAseq | -0.7625 | 0.0014 | |
| SRP193095 | RAB2A | 5862 | RNAseq | -0.9603 | 0.0000 | |
| SRP219564 | RAB2A | 5862 | RNAseq | -0.6088 | 0.0506 | |
| TCGA | RAB2A | 5862 | RNAseq | -0.0303 | 0.5195 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RAB2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB2A | 5862 | 13 | 1 | 16 | |
| GSE20123 | RAB2A | 5862 | 13 | 1 | 16 | |
| GSE43470 | RAB2A | 5862 | 14 | 3 | 26 | |
| GSE46452 | RAB2A | 5862 | 20 | 2 | 37 | |
| GSE47630 | RAB2A | 5862 | 23 | 1 | 16 | |
| GSE54993 | RAB2A | 5862 | 1 | 18 | 51 | |
| GSE54994 | RAB2A | 5862 | 30 | 0 | 23 | |
| GSE60625 | RAB2A | 5862 | 0 | 4 | 7 | |
| GSE74703 | RAB2A | 5862 | 12 | 2 | 22 | |
| GSE74704 | RAB2A | 5862 | 9 | 0 | 11 | |
| TCGA | RAB2A | 5862 | 46 | 5 | 45 |
Total number of gains: 181; Total number of losses: 37; Total Number of normals: 270.
Somatic mutations of RAB2A:
Generating mutation plots.
Highly correlated genes for RAB2A:
Showing top 20/1269 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB2A | UBE2L3 | 0.775911 | 3 | 0 | 3 |
| RAB2A | ECD | 0.761895 | 3 | 0 | 3 |
| RAB2A | UBE2W | 0.737372 | 3 | 0 | 3 |
| RAB2A | VDAC3 | 0.732176 | 3 | 0 | 3 |
| RAB2A | TMEM30A | 0.719842 | 3 | 0 | 3 |
| RAB2A | ATP6V1G1 | 0.719748 | 4 | 0 | 3 |
| RAB2A | ABHD14B | 0.715548 | 4 | 0 | 4 |
| RAB2A | POLB | 0.713293 | 4 | 0 | 4 |
| RAB2A | ACTR3 | 0.710265 | 4 | 0 | 3 |
| RAB2A | ARFGEF2 | 0.708964 | 5 | 0 | 4 |
| RAB2A | CCNYL1 | 0.707642 | 4 | 0 | 3 |
| RAB2A | ULK3 | 0.70657 | 7 | 0 | 7 |
| RAB2A | GGA3 | 0.705946 | 4 | 0 | 3 |
| RAB2A | EIF4E3 | 0.705309 | 4 | 0 | 3 |
| RAB2A | GOLGA4 | 0.700956 | 9 | 0 | 8 |
| RAB2A | ZACN | 0.698262 | 4 | 0 | 4 |
| RAB2A | SCAMP2 | 0.698127 | 6 | 0 | 6 |
| RAB2A | STX18 | 0.697557 | 4 | 0 | 4 |
| RAB2A | SCP2 | 0.696221 | 12 | 0 | 11 |
| RAB2A | KLHDC7A | 0.695683 | 3 | 0 | 3 |
For details and further investigation, click here
