| Full name: p21 (RAC1) activated kinase 6 | Alias Symbol: PAK5 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 56924 | HGNC ID: HGNC:16061 | Ensembl Gene: ENSG00000137843 | OMIM ID: 608110 |
| Drug and gene relationship at DGIdb | |||
PAK6 involved pathways:
Expression of PAK6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAK6 | 56924 | 1555310_a_at | -0.4772 | 0.1810 | |
| GSE20347 | PAK6 | 56924 | 219461_at | -0.6975 | 0.0003 | |
| GSE23400 | PAK6 | 56924 | 219461_at | -0.3861 | 0.0014 | |
| GSE26886 | PAK6 | 56924 | 1555310_a_at | -0.7845 | 0.0042 | |
| GSE29001 | PAK6 | 56924 | 219461_at | -0.4126 | 0.2802 | |
| GSE38129 | PAK6 | 56924 | 219461_at | -0.1456 | 0.6998 | |
| GSE45670 | PAK6 | 56924 | 1555310_a_at | -0.2006 | 0.3658 | |
| GSE63941 | PAK6 | 56924 | 1555310_a_at | 1.8276 | 0.0374 | |
| GSE77861 | PAK6 | 56924 | 1555310_a_at | -0.0772 | 0.7212 | |
| GSE97050 | PAK6 | 56924 | A_24_P159227 | 0.2602 | 0.6776 | |
| SRP007169 | PAK6 | 56924 | RNAseq | -2.2962 | 0.0000 | |
| SRP064894 | PAK6 | 56924 | RNAseq | -1.4154 | 0.0049 | |
| SRP133303 | PAK6 | 56924 | RNAseq | -1.2349 | 0.0004 | |
| SRP159526 | PAK6 | 56924 | RNAseq | -0.8970 | 0.1824 | |
| SRP219564 | PAK6 | 56924 | RNAseq | -1.6928 | 0.1868 | |
| TCGA | PAK6 | 56924 | RNAseq | 0.4145 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by PAK6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PAK6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAK6 | 56924 | 4 | 5 | 21 | |
| GSE20123 | PAK6 | 56924 | 4 | 5 | 21 | |
| GSE43470 | PAK6 | 56924 | 4 | 6 | 33 | |
| GSE46452 | PAK6 | 56924 | 3 | 7 | 49 | |
| GSE47630 | PAK6 | 56924 | 8 | 11 | 21 | |
| GSE54993 | PAK6 | 56924 | 4 | 6 | 60 | |
| GSE54994 | PAK6 | 56924 | 5 | 7 | 41 | |
| GSE60625 | PAK6 | 56924 | 4 | 0 | 7 | |
| GSE74703 | PAK6 | 56924 | 4 | 5 | 27 | |
| GSE74704 | PAK6 | 56924 | 3 | 3 | 14 | |
| TCGA | PAK6 | 56924 | 11 | 17 | 68 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of PAK6:
Generating mutation plots.
Highly correlated genes for PAK6:
Showing top 20/492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAK6 | VSIG10 | 0.711239 | 3 | 0 | 3 |
| PAK6 | GRIPAP1 | 0.70281 | 3 | 0 | 3 |
| PAK6 | GRHL2 | 0.699223 | 3 | 0 | 3 |
| PAK6 | RAET1E | 0.689645 | 4 | 0 | 3 |
| PAK6 | PLEKHN1 | 0.686291 | 4 | 0 | 4 |
| PAK6 | SHROOM4 | 0.679507 | 3 | 0 | 3 |
| PAK6 | RGS12 | 0.673028 | 7 | 0 | 6 |
| PAK6 | IGSF3 | 0.670134 | 3 | 0 | 3 |
| PAK6 | MIOS | 0.666664 | 6 | 0 | 6 |
| PAK6 | NANOS2 | 0.664961 | 4 | 0 | 4 |
| PAK6 | RAB10 | 0.659773 | 3 | 0 | 3 |
| PAK6 | GALNT5 | 0.657921 | 3 | 0 | 3 |
| PAK6 | TRIM29 | 0.657277 | 11 | 0 | 10 |
| PAK6 | VDR | 0.653647 | 4 | 0 | 3 |
| PAK6 | D2HGDH | 0.651983 | 3 | 0 | 3 |
| PAK6 | SIRT7 | 0.650936 | 8 | 0 | 7 |
| PAK6 | USH1C | 0.647001 | 3 | 0 | 3 |
| PAK6 | CLDN4 | 0.646806 | 7 | 0 | 5 |
| PAK6 | TXN | 0.646054 | 6 | 0 | 5 |
| PAK6 | GCHFR | 0.642347 | 7 | 0 | 6 |
For details and further investigation, click here
