| Full name: G protein-coupled receptor kinase 1 | Alias Symbol: GPRK1|RK | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 6011 | HGNC ID: HGNC:10013 | Ensembl Gene: ENSG00000185974 | OMIM ID: 180381 |
| Drug and gene relationship at DGIdb | |||
GRK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of GRK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRK1 | 6011 | 208041_at | -0.0706 | 0.7570 | |
| GSE20347 | GRK1 | 6011 | 208041_at | -0.0305 | 0.6278 | |
| GSE23400 | GRK1 | 6011 | 208041_at | -0.0832 | 0.0017 | |
| GSE26886 | GRK1 | 6011 | 208041_at | 0.3184 | 0.0183 | |
| GSE29001 | GRK1 | 6011 | 208041_at | -0.1034 | 0.3779 | |
| GSE38129 | GRK1 | 6011 | 208041_at | 0.0012 | 0.9909 | |
| GSE45670 | GRK1 | 6011 | 208041_at | -0.1133 | 0.3643 | |
| GSE53622 | GRK1 | 6011 | 26702 | 0.3477 | 0.0001 | |
| GSE53624 | GRK1 | 6011 | 26702 | 0.5103 | 0.0000 | |
| GSE63941 | GRK1 | 6011 | 208041_at | 0.0447 | 0.7971 | |
| GSE77861 | GRK1 | 6011 | 208041_at | -0.0268 | 0.8279 | |
| TCGA | GRK1 | 6011 | RNAseq | -1.7962 | 0.1315 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GRK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRK1 | 6011 | 6 | 12 | 12 | |
| GSE20123 | GRK1 | 6011 | 6 | 11 | 13 | |
| GSE43470 | GRK1 | 6011 | 4 | 13 | 26 | |
| GSE46452 | GRK1 | 6011 | 3 | 31 | 25 | |
| GSE47630 | GRK1 | 6011 | 3 | 26 | 11 | |
| GSE54993 | GRK1 | 6011 | 12 | 3 | 55 | |
| GSE54994 | GRK1 | 6011 | 9 | 10 | 34 | |
| GSE60625 | GRK1 | 6011 | 0 | 3 | 8 | |
| GSE74703 | GRK1 | 6011 | 3 | 10 | 23 | |
| GSE74704 | GRK1 | 6011 | 4 | 9 | 7 | |
| TCGA | GRK1 | 6011 | 19 | 32 | 45 |
Total number of gains: 69; Total number of losses: 160; Total Number of normals: 259.
Somatic mutations of GRK1:
Generating mutation plots.
Highly correlated genes for GRK1:
Showing top 20/611 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRK1 | ZNF358 | 0.709679 | 3 | 0 | 3 |
| GRK1 | TEX35 | 0.709064 | 3 | 0 | 3 |
| GRK1 | C11orf97 | 0.704555 | 3 | 0 | 3 |
| GRK1 | TSPAN16 | 0.696319 | 4 | 0 | 4 |
| GRK1 | KLK14 | 0.692932 | 3 | 0 | 3 |
| GRK1 | SSTR4 | 0.682966 | 4 | 0 | 4 |
| GRK1 | VAMP2 | 0.678651 | 3 | 0 | 3 |
| GRK1 | COL20A1 | 0.678399 | 3 | 0 | 3 |
| GRK1 | KCNK9 | 0.678043 | 3 | 0 | 3 |
| GRK1 | GUCA1B | 0.674407 | 4 | 0 | 3 |
| GRK1 | SHANK1 | 0.672306 | 4 | 0 | 4 |
| GRK1 | MC2R | 0.670831 | 3 | 0 | 3 |
| GRK1 | CDH15 | 0.664743 | 5 | 0 | 5 |
| GRK1 | TFAP4 | 0.663426 | 3 | 0 | 3 |
| GRK1 | MAPK8IP3 | 0.66297 | 3 | 0 | 3 |
| GRK1 | SYT5 | 0.661959 | 5 | 0 | 4 |
| GRK1 | INSRR | 0.658924 | 4 | 0 | 3 |
| GRK1 | LINC00598 | 0.656739 | 3 | 0 | 3 |
| GRK1 | OR2F1 | 0.655576 | 3 | 0 | 3 |
| GRK1 | CSF2 | 0.650972 | 5 | 0 | 4 |
For details and further investigation, click here
