| Full name: colony stimulating factor 2 | Alias Symbol: GM-CSF|GMCSF | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 1437 | HGNC ID: HGNC:2434 | Ensembl Gene: ENSG00000164400 | OMIM ID: 138960 |
| Drug and gene relationship at DGIdb | |||
CSF2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of CSF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSF2 | 1437 | 210228_at | 0.0171 | 0.9494 | |
| GSE20347 | CSF2 | 1437 | 210228_at | -0.0022 | 0.9859 | |
| GSE23400 | CSF2 | 1437 | 210228_at | -0.0179 | 0.4774 | |
| GSE26886 | CSF2 | 1437 | 210228_at | -0.0111 | 0.9225 | |
| GSE29001 | CSF2 | 1437 | 210228_at | -0.0738 | 0.6573 | |
| GSE38129 | CSF2 | 1437 | 210228_at | -0.1035 | 0.3862 | |
| GSE45670 | CSF2 | 1437 | 210228_at | 0.0584 | 0.5167 | |
| GSE53622 | CSF2 | 1437 | 57010 | 2.6353 | 0.0000 | |
| GSE53624 | CSF2 | 1437 | 57010 | 3.3621 | 0.0000 | |
| GSE63941 | CSF2 | 1437 | 210228_at | 0.3129 | 0.0391 | |
| GSE77861 | CSF2 | 1437 | 210228_at | -0.0322 | 0.8689 | |
| GSE97050 | CSF2 | 1437 | A_23_P133408 | 0.3554 | 0.2308 | |
| SRP159526 | CSF2 | 1437 | RNAseq | 6.5870 | 0.0000 | |
| TCGA | CSF2 | 1437 | RNAseq | 5.1201 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by CSF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSF2 | 1437 | 1 | 11 | 18 | |
| GSE20123 | CSF2 | 1437 | 1 | 11 | 18 | |
| GSE43470 | CSF2 | 1437 | 2 | 9 | 32 | |
| GSE46452 | CSF2 | 1437 | 0 | 27 | 32 | |
| GSE47630 | CSF2 | 1437 | 0 | 21 | 19 | |
| GSE54993 | CSF2 | 1437 | 9 | 1 | 60 | |
| GSE54994 | CSF2 | 1437 | 2 | 14 | 37 | |
| GSE60625 | CSF2 | 1437 | 0 | 0 | 11 | |
| GSE74703 | CSF2 | 1437 | 2 | 6 | 28 | |
| GSE74704 | CSF2 | 1437 | 1 | 5 | 14 | |
| TCGA | CSF2 | 1437 | 3 | 39 | 54 |
Total number of gains: 21; Total number of losses: 144; Total Number of normals: 323.
Somatic mutations of CSF2:
Generating mutation plots.
Highly correlated genes for CSF2:
Showing top 20/701 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSF2 | ELFN1 | 0.735709 | 3 | 0 | 3 |
| CSF2 | RFX2 | 0.727356 | 4 | 0 | 4 |
| CSF2 | FCGR2C | 0.726726 | 4 | 0 | 4 |
| CSF2 | WDR54 | 0.724119 | 3 | 0 | 3 |
| CSF2 | LRRC8C | 0.721157 | 3 | 0 | 3 |
| CSF2 | SIRPG | 0.719291 | 3 | 0 | 3 |
| CSF2 | OPHN1 | 0.708312 | 5 | 0 | 5 |
| CSF2 | FAM89A | 0.701603 | 3 | 0 | 3 |
| CSF2 | FJX1 | 0.695291 | 3 | 0 | 3 |
| CSF2 | TNPO1 | 0.690105 | 3 | 0 | 3 |
| CSF2 | CD5L | 0.688694 | 3 | 0 | 3 |
| CSF2 | CCM2 | 0.687615 | 3 | 0 | 3 |
| CSF2 | FMNL2 | 0.686332 | 3 | 0 | 3 |
| CSF2 | PATL1 | 0.684798 | 3 | 0 | 3 |
| CSF2 | PSMC3IP | 0.677743 | 3 | 0 | 3 |
| CSF2 | ATG10 | 0.676008 | 5 | 0 | 4 |
| CSF2 | APOBR | 0.674448 | 3 | 0 | 3 |
| CSF2 | PTPRT | 0.674307 | 4 | 0 | 3 |
| CSF2 | TNFSF8 | 0.673084 | 5 | 0 | 4 |
| CSF2 | CSN1S1 | 0.671885 | 3 | 0 | 3 |
For details and further investigation, click here
