| Full name: orthodenticle homeobox 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p15 | ||
| Entrez ID: 5013 | HGNC ID: HGNC:8521 | Ensembl Gene: ENSG00000115507 | OMIM ID: 600036 |
| Drug and gene relationship at DGIdb | |||
Expression of OTX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OTX1 | 5013 | 238839_at | 0.3684 | 0.1584 | |
| GSE26886 | OTX1 | 5013 | 238839_at | 0.2294 | 0.0364 | |
| GSE45670 | OTX1 | 5013 | 238839_at | 0.1092 | 0.1668 | |
| GSE53622 | OTX1 | 5013 | 97271 | 1.3389 | 0.0000 | |
| GSE53624 | OTX1 | 5013 | 97271 | 1.2397 | 0.0000 | |
| GSE63941 | OTX1 | 5013 | 238839_at | 0.4529 | 0.0517 | |
| GSE77861 | OTX1 | 5013 | 238839_at | 0.0974 | 0.4925 | |
| GSE97050 | OTX1 | 5013 | A_23_P403284 | 0.8347 | 0.1608 | |
| SRP007169 | OTX1 | 5013 | RNAseq | 3.0109 | 0.0028 | |
| SRP133303 | OTX1 | 5013 | RNAseq | 2.0206 | 0.0000 | |
| SRP159526 | OTX1 | 5013 | RNAseq | 2.8576 | 0.0000 | |
| SRP219564 | OTX1 | 5013 | RNAseq | 1.1919 | 0.1756 | |
| TCGA | OTX1 | 5013 | RNAseq | 1.3998 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by OTX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTX1 | 5013 | 12 | 0 | 18 | |
| GSE20123 | OTX1 | 5013 | 12 | 0 | 18 | |
| GSE43470 | OTX1 | 5013 | 7 | 0 | 36 | |
| GSE46452 | OTX1 | 5013 | 2 | 3 | 54 | |
| GSE47630 | OTX1 | 5013 | 8 | 0 | 32 | |
| GSE54993 | OTX1 | 5013 | 0 | 6 | 64 | |
| GSE54994 | OTX1 | 5013 | 12 | 0 | 41 | |
| GSE60625 | OTX1 | 5013 | 0 | 3 | 8 | |
| GSE74703 | OTX1 | 5013 | 7 | 0 | 29 | |
| GSE74704 | OTX1 | 5013 | 10 | 0 | 10 | |
| TCGA | OTX1 | 5013 | 36 | 2 | 58 |
Total number of gains: 106; Total number of losses: 14; Total Number of normals: 368.
Somatic mutations of OTX1:
Generating mutation plots.
Highly correlated genes for OTX1:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTX1 | MRPL12 | 0.735015 | 3 | 0 | 3 |
| OTX1 | ENTPD6 | 0.702353 | 3 | 0 | 3 |
| OTX1 | SLC25A22 | 0.693959 | 3 | 0 | 3 |
| OTX1 | FOXM1 | 0.675423 | 4 | 0 | 4 |
| OTX1 | TXNDC12 | 0.674475 | 3 | 0 | 3 |
| OTX1 | ZFP64 | 0.66233 | 6 | 0 | 5 |
| OTX1 | DHPS | 0.661811 | 3 | 0 | 3 |
| OTX1 | TMC6 | 0.660793 | 3 | 0 | 3 |
| OTX1 | GRK6 | 0.660259 | 3 | 0 | 3 |
| OTX1 | KIF14 | 0.659724 | 4 | 0 | 4 |
| OTX1 | DSN1 | 0.657728 | 3 | 0 | 3 |
| OTX1 | SIX1 | 0.656312 | 6 | 0 | 6 |
| OTX1 | ECT2 | 0.655735 | 4 | 0 | 3 |
| OTX1 | RALY | 0.655049 | 4 | 0 | 3 |
| OTX1 | RPS29 | 0.652775 | 3 | 0 | 3 |
| OTX1 | ZNF367 | 0.651885 | 4 | 0 | 4 |
| OTX1 | TOP2A | 0.648614 | 4 | 0 | 4 |
| OTX1 | CENPF | 0.648274 | 5 | 0 | 4 |
| OTX1 | CCDC14 | 0.646121 | 3 | 0 | 3 |
| OTX1 | UHRF1 | 0.645201 | 4 | 0 | 4 |
For details and further investigation, click here
