| Full name: dynamin 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 1759 | HGNC ID: HGNC:2972 | Ensembl Gene: ENSG00000106976 | OMIM ID: 602377 |
| Drug and gene relationship at DGIdb | |||
DNM1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05100 | Bacterial invasion of epithelial cells |
Expression of DNM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNM1 | 1759 | 215116_s_at | 0.5082 | 0.3107 | |
| GSE20347 | DNM1 | 1759 | 215116_s_at | 1.0272 | 0.0000 | |
| GSE23400 | DNM1 | 1759 | 215116_s_at | 0.8031 | 0.0000 | |
| GSE26886 | DNM1 | 1759 | 215116_s_at | 1.0327 | 0.0002 | |
| GSE29001 | DNM1 | 1759 | 215116_s_at | 1.2505 | 0.0099 | |
| GSE38129 | DNM1 | 1759 | 215116_s_at | 0.8376 | 0.0027 | |
| GSE45670 | DNM1 | 1759 | 215116_s_at | 0.1282 | 0.7609 | |
| GSE53622 | DNM1 | 1759 | 69710 | 0.1897 | 0.0013 | |
| GSE53624 | DNM1 | 1759 | 69710 | 0.2858 | 0.0000 | |
| GSE63941 | DNM1 | 1759 | 215116_s_at | 1.2426 | 0.2335 | |
| GSE77861 | DNM1 | 1759 | 215116_s_at | 0.7210 | 0.0679 | |
| GSE97050 | DNM1 | 1759 | A_33_P3329419 | 0.1691 | 0.4161 | |
| SRP007169 | DNM1 | 1759 | RNAseq | 3.7593 | 0.0000 | |
| SRP008496 | DNM1 | 1759 | RNAseq | 5.1495 | 0.0000 | |
| SRP064894 | DNM1 | 1759 | RNAseq | 1.4124 | 0.0000 | |
| SRP133303 | DNM1 | 1759 | RNAseq | 0.8056 | 0.0065 | |
| SRP159526 | DNM1 | 1759 | RNAseq | 1.6618 | 0.0007 | |
| SRP193095 | DNM1 | 1759 | RNAseq | 2.4156 | 0.0000 | |
| SRP219564 | DNM1 | 1759 | RNAseq | 0.9504 | 0.0837 | |
| TCGA | DNM1 | 1759 | RNAseq | 0.3986 | 0.0016 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by DNM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNM1 | 1759 | 6 | 9 | 15 | |
| GSE20123 | DNM1 | 1759 | 6 | 9 | 15 | |
| GSE43470 | DNM1 | 1759 | 5 | 7 | 31 | |
| GSE46452 | DNM1 | 1759 | 6 | 13 | 40 | |
| GSE47630 | DNM1 | 1759 | 3 | 16 | 21 | |
| GSE54993 | DNM1 | 1759 | 3 | 3 | 64 | |
| GSE54994 | DNM1 | 1759 | 11 | 8 | 34 | |
| GSE60625 | DNM1 | 1759 | 0 | 0 | 11 | |
| GSE74703 | DNM1 | 1759 | 5 | 5 | 26 | |
| GSE74704 | DNM1 | 1759 | 3 | 7 | 10 | |
| TCGA | DNM1 | 1759 | 26 | 26 | 44 |
Total number of gains: 74; Total number of losses: 103; Total Number of normals: 311.
Somatic mutations of DNM1:
Generating mutation plots.
Highly correlated genes for DNM1:
Showing top 20/857 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNM1 | BMF | 0.718495 | 3 | 0 | 3 |
| DNM1 | CD99L2 | 0.694085 | 3 | 0 | 3 |
| DNM1 | TP53I13 | 0.689894 | 4 | 0 | 3 |
| DNM1 | TRAM2 | 0.678031 | 8 | 0 | 8 |
| DNM1 | TRIM47 | 0.672402 | 3 | 0 | 3 |
| DNM1 | GRM3 | 0.662404 | 3 | 0 | 3 |
| DNM1 | MAPK15 | 0.662024 | 3 | 0 | 3 |
| DNM1 | TENM3 | 0.661818 | 3 | 0 | 3 |
| DNM1 | AIP | 0.661447 | 6 | 0 | 6 |
| DNM1 | COL4A2 | 0.658045 | 10 | 0 | 9 |
| DNM1 | CLEC11A | 0.656526 | 5 | 0 | 4 |
| DNM1 | CPSF4 | 0.655078 | 3 | 0 | 3 |
| DNM1 | TPM1 | 0.654911 | 3 | 0 | 3 |
| DNM1 | COL24A1 | 0.654161 | 4 | 0 | 4 |
| DNM1 | PLXND1 | 0.652466 | 8 | 0 | 8 |
| DNM1 | SIVA1 | 0.651837 | 8 | 0 | 7 |
| DNM1 | FARP1 | 0.651694 | 10 | 0 | 7 |
| DNM1 | TBX1 | 0.647489 | 3 | 0 | 3 |
| DNM1 | KLHL26 | 0.647311 | 5 | 0 | 5 |
| DNM1 | HEY1 | 0.646336 | 8 | 0 | 8 |
For details and further investigation, click here
