| Full name: POP1 homolog, ribonuclease P/MRP subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q22.2 | ||
| Entrez ID: 10940 | HGNC ID: HGNC:30129 | Ensembl Gene: ENSG00000104356 | OMIM ID: 602486 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of POP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POP1 | 10940 | 213449_at | 0.8695 | 0.0439 | |
| GSE20347 | POP1 | 10940 | 213449_at | 0.3822 | 0.0032 | |
| GSE23400 | POP1 | 10940 | 213449_at | 0.0897 | 0.0688 | |
| GSE26886 | POP1 | 10940 | 213449_at | -0.4666 | 0.0336 | |
| GSE29001 | POP1 | 10940 | 213449_at | 0.1097 | 0.5555 | |
| GSE38129 | POP1 | 10940 | 213449_at | 0.4514 | 0.0001 | |
| GSE45670 | POP1 | 10940 | 213449_at | 0.6209 | 0.0019 | |
| GSE53622 | POP1 | 10940 | 30047 | 0.7975 | 0.0000 | |
| GSE53624 | POP1 | 10940 | 30047 | 1.1222 | 0.0000 | |
| GSE63941 | POP1 | 10940 | 213449_at | -0.4427 | 0.3921 | |
| GSE77861 | POP1 | 10940 | 213449_at | 0.0555 | 0.7094 | |
| GSE97050 | POP1 | 10940 | A_23_P341275 | 0.7459 | 0.1399 | |
| SRP007169 | POP1 | 10940 | RNAseq | 1.4487 | 0.0137 | |
| SRP008496 | POP1 | 10940 | RNAseq | 1.0241 | 0.0046 | |
| SRP064894 | POP1 | 10940 | RNAseq | 0.7556 | 0.0023 | |
| SRP133303 | POP1 | 10940 | RNAseq | 0.5496 | 0.0058 | |
| SRP159526 | POP1 | 10940 | RNAseq | 0.7659 | 0.0142 | |
| SRP193095 | POP1 | 10940 | RNAseq | 0.6494 | 0.0000 | |
| SRP219564 | POP1 | 10940 | RNAseq | 0.6196 | 0.2244 | |
| TCGA | POP1 | 10940 | RNAseq | 0.3920 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by POP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POP1 | 10940 | 16 | 0 | 14 | |
| GSE20123 | POP1 | 10940 | 17 | 0 | 13 | |
| GSE43470 | POP1 | 10940 | 21 | 1 | 21 | |
| GSE46452 | POP1 | 10940 | 23 | 0 | 36 | |
| GSE47630 | POP1 | 10940 | 24 | 0 | 16 | |
| GSE54993 | POP1 | 10940 | 0 | 20 | 50 | |
| GSE54994 | POP1 | 10940 | 37 | 1 | 15 | |
| GSE60625 | POP1 | 10940 | 0 | 4 | 7 | |
| GSE74703 | POP1 | 10940 | 18 | 1 | 17 | |
| GSE74704 | POP1 | 10940 | 12 | 0 | 8 | |
| TCGA | POP1 | 10940 | 56 | 1 | 39 |
Total number of gains: 224; Total number of losses: 28; Total Number of normals: 236.
Somatic mutations of POP1:
Generating mutation plots.
Highly correlated genes for POP1:
Showing top 20/576 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POP1 | BOP1 | 0.733288 | 3 | 0 | 3 |
| POP1 | UHRF1 | 0.733159 | 5 | 0 | 5 |
| POP1 | GTF2H4 | 0.728819 | 3 | 0 | 3 |
| POP1 | SPC24 | 0.711465 | 5 | 0 | 5 |
| POP1 | STIL | 0.704082 | 8 | 0 | 7 |
| POP1 | CCNA2 | 0.696816 | 7 | 0 | 7 |
| POP1 | KIF2C | 0.695758 | 7 | 0 | 7 |
| POP1 | FAM91A1 | 0.694171 | 5 | 0 | 5 |
| POP1 | SDF2L1 | 0.693091 | 5 | 0 | 4 |
| POP1 | TAF5L | 0.686235 | 3 | 0 | 3 |
| POP1 | ECT2 | 0.677904 | 7 | 0 | 7 |
| POP1 | UBE2J2 | 0.676901 | 3 | 0 | 3 |
| POP1 | TOP2A | 0.674593 | 8 | 0 | 7 |
| POP1 | IQGAP3 | 0.674486 | 4 | 0 | 4 |
| POP1 | TACC3 | 0.671752 | 8 | 0 | 7 |
| POP1 | NUF2 | 0.671678 | 5 | 0 | 4 |
| POP1 | RCC2 | 0.67102 | 5 | 0 | 4 |
| POP1 | NEK2 | 0.67024 | 8 | 0 | 7 |
| POP1 | CENPF | 0.669128 | 8 | 0 | 7 |
| POP1 | U2SURP | 0.668001 | 4 | 0 | 4 |
For details and further investigation, click here
