| Full name: protein kinase C zeta | Alias Symbol: PKC2 | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 5590 | HGNC ID: HGNC:9412 | Ensembl Gene: ENSG00000067606 | OMIM ID: 176982 |
| Drug and gene relationship at DGIdb | |||
PRKCZ involved pathways:
Expression of PRKCZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKCZ | 5590 | 202178_at | 0.5381 | 0.4094 | |
| GSE20347 | PRKCZ | 5590 | 202178_at | -0.3330 | 0.0079 | |
| GSE23400 | PRKCZ | 5590 | 202178_at | -0.0601 | 0.5590 | |
| GSE26886 | PRKCZ | 5590 | 202178_at | 0.2776 | 0.2667 | |
| GSE29001 | PRKCZ | 5590 | 202178_at | -0.3607 | 0.2225 | |
| GSE38129 | PRKCZ | 5590 | 202178_at | 0.0574 | 0.7915 | |
| GSE45670 | PRKCZ | 5590 | 202178_at | 0.1409 | 0.4127 | |
| GSE63941 | PRKCZ | 5590 | 202178_at | 2.5168 | 0.0004 | |
| GSE77861 | PRKCZ | 5590 | 202178_at | -0.2192 | 0.3068 | |
| GSE97050 | PRKCZ | 5590 | A_23_P51187 | 0.4758 | 0.1714 | |
| SRP007169 | PRKCZ | 5590 | RNAseq | -1.7303 | 0.0001 | |
| SRP008496 | PRKCZ | 5590 | RNAseq | -1.6765 | 0.0000 | |
| SRP064894 | PRKCZ | 5590 | RNAseq | -0.3232 | 0.2819 | |
| SRP133303 | PRKCZ | 5590 | RNAseq | -0.2705 | 0.1033 | |
| SRP159526 | PRKCZ | 5590 | RNAseq | -0.1820 | 0.6665 | |
| SRP193095 | PRKCZ | 5590 | RNAseq | -0.6027 | 0.0000 | |
| SRP219564 | PRKCZ | 5590 | RNAseq | -0.4621 | 0.4957 | |
| TCGA | PRKCZ | 5590 | RNAseq | 0.0864 | 0.2022 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by PRKCZ expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PRKCZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKCZ | 5590 | 4 | 7 | 19 | |
| GSE20123 | PRKCZ | 5590 | 4 | 6 | 20 | |
| GSE43470 | PRKCZ | 5590 | 3 | 5 | 35 | |
| GSE46452 | PRKCZ | 5590 | 7 | 1 | 51 | |
| GSE47630 | PRKCZ | 5590 | 8 | 4 | 28 | |
| GSE54993 | PRKCZ | 5590 | 2 | 2 | 66 | |
| GSE54994 | PRKCZ | 5590 | 15 | 2 | 36 | |
| GSE60625 | PRKCZ | 5590 | 0 | 0 | 11 | |
| GSE74703 | PRKCZ | 5590 | 3 | 3 | 30 | |
| GSE74704 | PRKCZ | 5590 | 4 | 0 | 16 | |
| TCGA | PRKCZ | 5590 | 14 | 20 | 62 |
Total number of gains: 64; Total number of losses: 50; Total Number of normals: 374.
Somatic mutations of PRKCZ:
Generating mutation plots.
Highly correlated genes for PRKCZ:
Showing top 20/327 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKCZ | SHKBP1 | 0.777509 | 3 | 0 | 3 |
| PRKCZ | RCC2 | 0.764286 | 3 | 0 | 3 |
| PRKCZ | GTF2H4 | 0.753738 | 3 | 0 | 3 |
| PRKCZ | SYTL1 | 0.74223 | 3 | 0 | 3 |
| PRKCZ | WDR34 | 0.73303 | 3 | 0 | 3 |
| PRKCZ | PLEKHH1 | 0.729588 | 3 | 0 | 3 |
| PRKCZ | FANCD2 | 0.723997 | 3 | 0 | 3 |
| PRKCZ | JAG2 | 0.714958 | 3 | 0 | 3 |
| PRKCZ | KIAA1522 | 0.70773 | 3 | 0 | 3 |
| PRKCZ | TFAP2C | 0.682073 | 4 | 0 | 3 |
| PRKCZ | C1orf74 | 0.681149 | 3 | 0 | 3 |
| PRKCZ | DUS1L | 0.680269 | 4 | 0 | 3 |
| PRKCZ | BMP8B | 0.679262 | 3 | 0 | 3 |
| PRKCZ | SRD5A1 | 0.678454 | 4 | 0 | 4 |
| PRKCZ | IQGAP3 | 0.678018 | 3 | 0 | 3 |
| PRKCZ | ARRDC1 | 0.674241 | 5 | 0 | 5 |
| PRKCZ | ZAP70 | 0.669841 | 3 | 0 | 3 |
| PRKCZ | ST14 | 0.668973 | 8 | 0 | 7 |
| PRKCZ | GPR160 | 0.668608 | 3 | 0 | 3 |
| PRKCZ | POU2F1 | 0.666423 | 3 | 0 | 3 |
For details and further investigation, click here
