| Full name: granulysin | Alias Symbol: NKG5|LAG-2|D2S69E|TLA519 | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 10578 | HGNC ID: HGNC:4414 | Ensembl Gene: ENSG00000115523 | OMIM ID: 188855 |
| Drug and gene relationship at DGIdb | |||
Expression of GNLY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNLY | 10578 | 205495_s_at | 0.8435 | 0.2361 | |
| GSE20347 | GNLY | 10578 | 205495_s_at | 0.4625 | 0.0679 | |
| GSE23400 | GNLY | 10578 | 37145_at | 0.3916 | 0.0013 | |
| GSE26886 | GNLY | 10578 | 205495_s_at | 1.2291 | 0.0099 | |
| GSE29001 | GNLY | 10578 | 205495_s_at | 0.9513 | 0.0219 | |
| GSE38129 | GNLY | 10578 | 37145_at | 0.5467 | 0.0432 | |
| GSE45670 | GNLY | 10578 | 205495_s_at | 0.6292 | 0.1020 | |
| GSE53622 | GNLY | 10578 | 85260 | 0.7086 | 0.0000 | |
| GSE53624 | GNLY | 10578 | 85260 | 0.7861 | 0.0000 | |
| GSE63941 | GNLY | 10578 | 205495_s_at | -0.0133 | 0.9491 | |
| GSE77861 | GNLY | 10578 | 205495_s_at | 0.0091 | 0.9720 | |
| GSE97050 | GNLY | 10578 | A_23_P209954 | 0.7773 | 0.2307 | |
| SRP064894 | GNLY | 10578 | RNAseq | 1.0716 | 0.0044 | |
| SRP133303 | GNLY | 10578 | RNAseq | 2.0009 | 0.0002 | |
| SRP159526 | GNLY | 10578 | RNAseq | 0.7100 | 0.2269 | |
| SRP193095 | GNLY | 10578 | RNAseq | 1.3081 | 0.0000 | |
| SRP219564 | GNLY | 10578 | RNAseq | 2.0174 | 0.0167 | |
| TCGA | GNLY | 10578 | RNAseq | 1.2975 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by GNLY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNLY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNLY | 10578 | 9 | 2 | 19 | |
| GSE20123 | GNLY | 10578 | 9 | 2 | 19 | |
| GSE43470 | GNLY | 10578 | 6 | 2 | 35 | |
| GSE46452 | GNLY | 10578 | 2 | 3 | 54 | |
| GSE47630 | GNLY | 10578 | 7 | 0 | 33 | |
| GSE54993 | GNLY | 10578 | 0 | 6 | 64 | |
| GSE54994 | GNLY | 10578 | 10 | 0 | 43 | |
| GSE60625 | GNLY | 10578 | 0 | 3 | 8 | |
| GSE74703 | GNLY | 10578 | 5 | 1 | 30 | |
| GSE74704 | GNLY | 10578 | 7 | 0 | 13 | |
| TCGA | GNLY | 10578 | 35 | 4 | 57 |
Total number of gains: 90; Total number of losses: 23; Total Number of normals: 375.
Somatic mutations of GNLY:
Generating mutation plots.
Highly correlated genes for GNLY:
Showing top 20/275 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNLY | CXCL11 | 0.717845 | 9 | 0 | 9 |
| GNLY | GZMA | 0.710743 | 10 | 0 | 9 |
| GNLY | GZMB | 0.702948 | 11 | 0 | 10 |
| GNLY | PABPC1L | 0.696067 | 3 | 0 | 3 |
| GNLY | PSMB9 | 0.695966 | 11 | 0 | 11 |
| GNLY | BATF2 | 0.691211 | 7 | 0 | 5 |
| GNLY | HAPLN3 | 0.688398 | 5 | 0 | 5 |
| GNLY | ZBTB48 | 0.684737 | 3 | 0 | 3 |
| GNLY | UBE2L6 | 0.68432 | 11 | 0 | 11 |
| GNLY | C7orf61 | 0.683439 | 3 | 0 | 3 |
| GNLY | PGC | 0.676998 | 3 | 0 | 3 |
| GNLY | FCGR1B | 0.672537 | 8 | 0 | 6 |
| GNLY | LAG3 | 0.670054 | 10 | 0 | 9 |
| GNLY | PRF1 | 0.668536 | 11 | 0 | 8 |
| GNLY | ORM1 | 0.668018 | 3 | 0 | 3 |
| GNLY | IL15RA | 0.666315 | 11 | 0 | 10 |
| GNLY | CXCL9 | 0.666291 | 9 | 0 | 8 |
| GNLY | NLRC5 | 0.665849 | 6 | 0 | 5 |
| GNLY | ADCK5 | 0.665286 | 3 | 0 | 3 |
| GNLY | TBX21 | 0.664718 | 4 | 0 | 4 |
For details and further investigation, click here
