| Full name: perforin 1 | Alias Symbol: PFP|P1|HPLH2 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 5551 | HGNC ID: HGNC:9360 | Ensembl Gene: ENSG00000180644 | OMIM ID: 170280 |
| Drug and gene relationship at DGIdb | |||
Expression of PRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRF1 | 5551 | 214617_at | 0.5126 | 0.5873 | |
| GSE20347 | PRF1 | 5551 | 214617_at | -0.0538 | 0.7145 | |
| GSE23400 | PRF1 | 5551 | 214617_at | 0.0439 | 0.5629 | |
| GSE26886 | PRF1 | 5551 | 214617_at | -0.1829 | 0.5786 | |
| GSE29001 | PRF1 | 5551 | 214617_at | 0.1051 | 0.6734 | |
| GSE38129 | PRF1 | 5551 | 214617_at | -0.2598 | 0.0430 | |
| GSE45670 | PRF1 | 5551 | 214617_at | 0.0572 | 0.8512 | |
| GSE53622 | PRF1 | 5551 | 23719 | 0.2427 | 0.1544 | |
| GSE53624 | PRF1 | 5551 | 23719 | 0.4955 | 0.0001 | |
| GSE63941 | PRF1 | 5551 | 214617_at | 0.0080 | 0.9658 | |
| GSE77861 | PRF1 | 5551 | 1553681_a_at | -0.0162 | 0.9039 | |
| GSE97050 | PRF1 | 5551 | A_23_P1473 | 0.2447 | 0.3240 | |
| SRP007169 | PRF1 | 5551 | RNAseq | 0.8891 | 0.2749 | |
| SRP064894 | PRF1 | 5551 | RNAseq | 0.4008 | 0.2436 | |
| SRP133303 | PRF1 | 5551 | RNAseq | 0.3614 | 0.3541 | |
| SRP159526 | PRF1 | 5551 | RNAseq | -0.1731 | 0.8487 | |
| SRP193095 | PRF1 | 5551 | RNAseq | 0.1040 | 0.6230 | |
| SRP219564 | PRF1 | 5551 | RNAseq | 1.2058 | 0.0278 | |
| TCGA | PRF1 | 5551 | RNAseq | 0.2824 | 0.2064 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRF1 | 5551 | 2 | 4 | 24 | |
| GSE20123 | PRF1 | 5551 | 2 | 3 | 25 | |
| GSE43470 | PRF1 | 5551 | 1 | 7 | 35 | |
| GSE46452 | PRF1 | 5551 | 0 | 11 | 48 | |
| GSE47630 | PRF1 | 5551 | 2 | 14 | 24 | |
| GSE54993 | PRF1 | 5551 | 7 | 0 | 63 | |
| GSE54994 | PRF1 | 5551 | 2 | 11 | 40 | |
| GSE60625 | PRF1 | 5551 | 0 | 0 | 11 | |
| GSE74703 | PRF1 | 5551 | 1 | 4 | 31 | |
| GSE74704 | PRF1 | 5551 | 1 | 1 | 18 | |
| TCGA | PRF1 | 5551 | 10 | 22 | 64 |
Total number of gains: 28; Total number of losses: 77; Total Number of normals: 383.
Somatic mutations of PRF1:
Generating mutation plots.
Highly correlated genes for PRF1:
Showing top 20/154 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRF1 | GZMA | 0.747609 | 11 | 0 | 10 |
| PRF1 | GZMB | 0.715186 | 11 | 0 | 10 |
| PRF1 | CD3D | 0.712442 | 10 | 0 | 10 |
| PRF1 | IL2RG | 0.711508 | 6 | 0 | 6 |
| PRF1 | LAG3 | 0.693263 | 11 | 0 | 10 |
| PRF1 | TIGIT | 0.689676 | 5 | 0 | 5 |
| PRF1 | CCR5 | 0.689594 | 9 | 0 | 9 |
| PRF1 | PIK3AP1 | 0.686488 | 3 | 0 | 3 |
| PRF1 | LILRA1 | 0.68576 | 4 | 0 | 4 |
| PRF1 | ADAMTS13 | 0.678475 | 3 | 0 | 3 |
| PRF1 | GZMH | 0.670991 | 10 | 0 | 8 |
| PRF1 | GNLY | 0.668536 | 11 | 0 | 8 |
| PRF1 | IL2RB | 0.66741 | 11 | 0 | 9 |
| PRF1 | LAIR1 | 0.651528 | 6 | 0 | 5 |
| PRF1 | IL12RB1 | 0.651412 | 6 | 0 | 5 |
| PRF1 | IFNG | 0.649269 | 8 | 0 | 7 |
| PRF1 | SIGLEC10 | 0.645409 | 7 | 0 | 6 |
| PRF1 | CD2 | 0.644711 | 11 | 0 | 10 |
| PRF1 | CD5 | 0.642266 | 4 | 0 | 3 |
| PRF1 | EOMES | 0.637817 | 3 | 0 | 3 |
For details and further investigation, click here
