GZMB

 

Full name: granzyme B Alias Symbol: CCPI|CGL-1|CSP-B|CGL1|CTSGL1|HLP|SECT
Type: protein-coding gene Cytoband: 14q12
Entrez ID: 3002 HGNC ID: HGNC:4709 Ensembl Gene: ENSG00000100453 OMIM ID: 123910
Drug and gene relationship at DGIdb

 

GZMB involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa04650Natural killer cell mediated cytotoxicity

 

Expression of GZMB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GZMB 3002 210164_at 1.3702 0.2556
GSE20347 GZMB 3002 210164_at 0.5409 0.1766
GSE23400 GZMB 3002 210164_at 0.3562 0.0028
GSE26886 GZMB 3002 210164_at 0.7231 0.3313
GSE29001 GZMB 3002 210164_at 0.7036 0.1106
GSE38129 GZMB 3002 210164_at 0.6079 0.0510
GSE45670 GZMB 3002 210164_at 0.9649 0.0154
GSE53622 GZMB 3002 21319 1.0626 0.0000
GSE53624 GZMB 3002 21319 1.1431 0.0000
GSE63941 GZMB 3002 210164_at 0.3395 0.0150
GSE77861 GZMB 3002 210164_at 0.3188 0.0311
GSE97050 GZMB 3002 A_23_P117602 0.9578 0.1754
SRP064894 GZMB 3002 RNAseq 0.8639 0.0139
SRP133303 GZMB 3002 RNAseq 1.6309 0.0001
SRP159526 GZMB 3002 RNAseq 1.5573 0.1320
SRP219564 GZMB 3002 RNAseq 1.6425 0.0198
TCGA GZMB 3002 RNAseq 0.7623 0.0010

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by GZMB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GZMB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GZMB 3002 8 3 19
GSE20123 GZMB 3002 8 3 19
GSE43470 GZMB 3002 9 2 32
GSE46452 GZMB 3002 16 2 41
GSE47630 GZMB 3002 11 10 19
GSE54993 GZMB 3002 3 11 56
GSE54994 GZMB 3002 18 5 30
GSE60625 GZMB 3002 0 2 9
GSE74703 GZMB 3002 8 2 26
GSE74704 GZMB 3002 3 2 15
TCGA GZMB 3002 27 12 57

Total number of gains: 111; Total number of losses: 54; Total Number of normals: 323.  

 

Somatic mutations of GZMB:

 

Generating mutation plots.

 

Highly correlated genes for GZMB:

 

Showing top 20/394 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GZMBTIGIT0.774562606
GZMBGZMA0.74577911011
GZMBCXCL90.72338912012
GZMBTAP10.71925610010
GZMBEPSTI10.718095707
GZMBPRF10.71518611010
GZMBCXCL110.70615812011
GZMBUBE2L60.7031212012
GZMBGNLY0.70294811010
GZMBLRRC250.701053303
GZMBCXCL100.69952212012
GZMBIL2RB0.6990871109
GZMBPSMB8-AS10.698514505
GZMBIRF10.69739910010
GZMBNKG70.69569911010
GZMBIDO10.68616311010
GZMBTFEC0.68353610010
GZMBLAG30.6826511009
GZMBNPHP40.681267303
GZMBCMPK20.677481707

For details and further investigation, click here