| Full name: CD8a molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 925 | HGNC ID: HGNC:1706 | Ensembl Gene: ENSG00000153563 | OMIM ID: 186910 |
| Drug and gene relationship at DGIdb | |||
CD8A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04660 | T cell receptor signaling pathway |
Expression of CD8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD8A | 925 | 205758_at | 0.5709 | 0.6342 | |
| GSE20347 | CD8A | 925 | 205758_at | -0.3733 | 0.0858 | |
| GSE23400 | CD8A | 925 | 205758_at | -0.2282 | 0.0001 | |
| GSE26886 | CD8A | 925 | 205758_at | -0.3545 | 0.3914 | |
| GSE29001 | CD8A | 925 | 205758_at | -0.3540 | 0.1890 | |
| GSE38129 | CD8A | 925 | 205758_at | -0.6182 | 0.0068 | |
| GSE45670 | CD8A | 925 | 205758_at | -0.4723 | 0.2409 | |
| GSE53622 | CD8A | 925 | 29241 | -0.3021 | 0.0753 | |
| GSE53624 | CD8A | 925 | 29241 | -0.3978 | 0.0001 | |
| GSE63941 | CD8A | 925 | 205758_at | 0.4257 | 0.2109 | |
| GSE77861 | CD8A | 925 | 205758_at | -0.1992 | 0.3685 | |
| GSE97050 | CD8A | 925 | A_33_P3228837 | 0.3822 | 0.3915 | |
| SRP007169 | CD8A | 925 | RNAseq | -0.6375 | 0.4780 | |
| SRP064894 | CD8A | 925 | RNAseq | -0.7953 | 0.0229 | |
| SRP133303 | CD8A | 925 | RNAseq | -0.5174 | 0.2028 | |
| SRP159526 | CD8A | 925 | RNAseq | -0.6684 | 0.4265 | |
| SRP193095 | CD8A | 925 | RNAseq | -0.9994 | 0.0003 | |
| SRP219564 | CD8A | 925 | RNAseq | 1.3739 | 0.0115 | |
| TCGA | CD8A | 925 | RNAseq | -0.1171 | 0.6546 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CD8A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD8A | 925 | 9 | 2 | 19 | |
| GSE20123 | CD8A | 925 | 9 | 2 | 19 | |
| GSE43470 | CD8A | 925 | 3 | 2 | 38 | |
| GSE46452 | CD8A | 925 | 2 | 3 | 54 | |
| GSE47630 | CD8A | 925 | 7 | 0 | 33 | |
| GSE54993 | CD8A | 925 | 0 | 6 | 64 | |
| GSE54994 | CD8A | 925 | 10 | 0 | 43 | |
| GSE60625 | CD8A | 925 | 0 | 3 | 8 | |
| GSE74703 | CD8A | 925 | 3 | 1 | 32 | |
| GSE74704 | CD8A | 925 | 7 | 0 | 13 | |
| TCGA | CD8A | 925 | 35 | 4 | 57 |
Total number of gains: 85; Total number of losses: 23; Total Number of normals: 380.
Somatic mutations of CD8A:
Generating mutation plots.
Highly correlated genes for CD8A:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD8A | CD3D | 0.723153 | 11 | 0 | 10 |
| CD8A | TRG-AS1 | 0.706923 | 4 | 0 | 4 |
| CD8A | CD2 | 0.705342 | 12 | 0 | 10 |
| CD8A | TMC8 | 0.703887 | 3 | 0 | 3 |
| CD8A | GZMA | 0.693947 | 9 | 0 | 8 |
| CD8A | GZMH | 0.693739 | 9 | 0 | 8 |
| CD8A | GBP4 | 0.6838 | 6 | 0 | 6 |
| CD8A | IGLL1 | 0.680866 | 3 | 0 | 3 |
| CD8A | NKG7 | 0.668621 | 12 | 0 | 9 |
| CD8A | CD96 | 0.667434 | 10 | 0 | 9 |
| CD8A | GPR171 | 0.661598 | 11 | 0 | 10 |
| CD8A | HCST | 0.654612 | 7 | 0 | 6 |
| CD8A | HAVCR2 | 0.649325 | 3 | 0 | 3 |
| CD8A | SLA2 | 0.643498 | 6 | 0 | 5 |
| CD8A | CD247 | 0.643261 | 8 | 0 | 7 |
| CD8A | RASAL3 | 0.632996 | 4 | 0 | 3 |
| CD8A | BTNL8 | 0.630365 | 3 | 0 | 3 |
| CD8A | CRTAM | 0.630134 | 6 | 0 | 4 |
| CD8A | CD48 | 0.628823 | 12 | 0 | 10 |
| CD8A | PRF1 | 0.627396 | 12 | 0 | 9 |
For details and further investigation, click here
