| Full name: granzyme K | Alias Symbol: TRYP2|PRSS | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 3003 | HGNC ID: HGNC:4711 | Ensembl Gene: ENSG00000113088 | OMIM ID: 600784 |
| Drug and gene relationship at DGIdb | |||
Expression of GZMK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GZMK | 3003 | 206666_at | -0.0696 | 0.9779 | |
| GSE20347 | GZMK | 3003 | 206666_at | -0.3028 | 0.0656 | |
| GSE23400 | GZMK | 3003 | 206666_at | -0.1338 | 0.0491 | |
| GSE26886 | GZMK | 3003 | 206666_at | -0.4759 | 0.2714 | |
| GSE29001 | GZMK | 3003 | 206666_at | -0.2400 | 0.3293 | |
| GSE38129 | GZMK | 3003 | 206666_at | -0.4205 | 0.1698 | |
| GSE45670 | GZMK | 3003 | 206666_at | -1.0414 | 0.0022 | |
| GSE63941 | GZMK | 3003 | 206666_at | 0.1046 | 0.5576 | |
| GSE77861 | GZMK | 3003 | 206666_at | -0.1171 | 0.3250 | |
| GSE97050 | GZMK | 3003 | A_23_P156218 | 0.8630 | 0.2272 | |
| SRP064894 | GZMK | 3003 | RNAseq | -0.4212 | 0.3523 | |
| SRP133303 | GZMK | 3003 | RNAseq | -0.9077 | 0.0435 | |
| SRP159526 | GZMK | 3003 | RNAseq | -1.2778 | 0.3050 | |
| SRP219564 | GZMK | 3003 | RNAseq | 0.3589 | 0.5631 | |
| TCGA | GZMK | 3003 | RNAseq | -0.0979 | 0.8333 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GZMK expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GZMK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GZMK | 3003 | 1 | 13 | 16 | |
| GSE20123 | GZMK | 3003 | 1 | 13 | 16 | |
| GSE43470 | GZMK | 3003 | 1 | 12 | 30 | |
| GSE46452 | GZMK | 3003 | 1 | 27 | 31 | |
| GSE47630 | GZMK | 3003 | 2 | 16 | 22 | |
| GSE54993 | GZMK | 3003 | 8 | 1 | 61 | |
| GSE54994 | GZMK | 3003 | 4 | 19 | 30 | |
| GSE60625 | GZMK | 3003 | 0 | 0 | 11 | |
| GSE74703 | GZMK | 3003 | 1 | 9 | 26 | |
| GSE74704 | GZMK | 3003 | 1 | 6 | 13 | |
| TCGA | GZMK | 3003 | 8 | 45 | 43 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of GZMK:
Generating mutation plots.
Highly correlated genes for GZMK:
Showing top 20/285 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GZMK | C16orf54 | 0.787121 | 4 | 0 | 4 |
| GZMK | CD3D | 0.758441 | 9 | 0 | 9 |
| GZMK | CD180 | 0.747698 | 4 | 0 | 4 |
| GZMK | GIMAP7 | 0.747007 | 5 | 0 | 5 |
| GZMK | SUSD3 | 0.73607 | 4 | 0 | 4 |
| GZMK | CORO1A | 0.732378 | 8 | 0 | 8 |
| GZMK | CD48 | 0.731409 | 9 | 0 | 8 |
| GZMK | MPEG1 | 0.730732 | 4 | 0 | 4 |
| GZMK | CD2 | 0.724592 | 9 | 0 | 9 |
| GZMK | ITK | 0.719985 | 9 | 0 | 9 |
| GZMK | CST7 | 0.717172 | 9 | 0 | 9 |
| GZMK | TNFAIP8L2 | 0.716568 | 5 | 0 | 5 |
| GZMK | TNFSF8 | 0.714815 | 4 | 0 | 4 |
| GZMK | PARVG | 0.71172 | 4 | 0 | 3 |
| GZMK | TAGAP | 0.704151 | 3 | 0 | 3 |
| GZMK | TRG-AS1 | 0.70404 | 4 | 0 | 4 |
| GZMK | ENPP2 | 0.699612 | 5 | 0 | 5 |
| GZMK | GPR171 | 0.699361 | 8 | 0 | 8 |
| GZMK | PVRIG | 0.695314 | 9 | 0 | 8 |
| GZMK | IL2RG | 0.693942 | 6 | 0 | 6 |
For details and further investigation, click here
