| Full name: schlafen family member 12 | Alias Symbol: FLJ10260 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 55106 | HGNC ID: HGNC:25500 | Ensembl Gene: ENSG00000172123 | OMIM ID: 614955 |
| Drug and gene relationship at DGIdb | |||
Expression of SLFN12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLFN12 | 55106 | 219885_at | 0.3976 | 0.5926 | |
| GSE20347 | SLFN12 | 55106 | 219885_at | 0.1682 | 0.4547 | |
| GSE23400 | SLFN12 | 55106 | 219885_at | 0.0630 | 0.0803 | |
| GSE26886 | SLFN12 | 55106 | 219885_at | -0.0904 | 0.8225 | |
| GSE29001 | SLFN12 | 55106 | 219885_at | -0.0602 | 0.7756 | |
| GSE38129 | SLFN12 | 55106 | 219885_at | 0.2946 | 0.0808 | |
| GSE45670 | SLFN12 | 55106 | 219885_at | 0.1067 | 0.7895 | |
| GSE53622 | SLFN12 | 55106 | 129560 | 0.1184 | 0.5286 | |
| GSE53624 | SLFN12 | 55106 | 129560 | 0.1681 | 0.4059 | |
| GSE63941 | SLFN12 | 55106 | 219885_at | -2.8794 | 0.0247 | |
| GSE77861 | SLFN12 | 55106 | 219885_at | -0.0939 | 0.5304 | |
| GSE97050 | SLFN12 | 55106 | A_23_P118536 | 0.2147 | 0.3874 | |
| SRP007169 | SLFN12 | 55106 | RNAseq | 1.2970 | 0.0090 | |
| SRP008496 | SLFN12 | 55106 | RNAseq | 1.1481 | 0.0018 | |
| SRP064894 | SLFN12 | 55106 | RNAseq | 0.3634 | 0.1658 | |
| SRP133303 | SLFN12 | 55106 | RNAseq | 0.5634 | 0.0019 | |
| SRP159526 | SLFN12 | 55106 | RNAseq | 0.7464 | 0.0689 | |
| SRP193095 | SLFN12 | 55106 | RNAseq | 0.1652 | 0.2115 | |
| SRP219564 | SLFN12 | 55106 | RNAseq | 0.1908 | 0.6885 | |
| TCGA | SLFN12 | 55106 | RNAseq | 0.0547 | 0.7517 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SLFN12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLFN12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLFN12 | 55106 | 5 | 1 | 24 | |
| GSE20123 | SLFN12 | 55106 | 5 | 1 | 24 | |
| GSE43470 | SLFN12 | 55106 | 1 | 2 | 40 | |
| GSE46452 | SLFN12 | 55106 | 34 | 0 | 25 | |
| GSE47630 | SLFN12 | 55106 | 7 | 1 | 32 | |
| GSE54993 | SLFN12 | 55106 | 3 | 3 | 64 | |
| GSE54994 | SLFN12 | 55106 | 8 | 6 | 39 | |
| GSE60625 | SLFN12 | 55106 | 4 | 0 | 7 | |
| GSE74703 | SLFN12 | 55106 | 1 | 1 | 34 | |
| GSE74704 | SLFN12 | 55106 | 3 | 1 | 16 | |
| TCGA | SLFN12 | 55106 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of SLFN12:
Generating mutation plots.
Highly correlated genes for SLFN12:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLFN12 | SH3RF3 | 0.767372 | 3 | 0 | 3 |
| SLFN12 | SPRED1 | 0.760885 | 3 | 0 | 3 |
| SLFN12 | PDGFRB | 0.752592 | 3 | 0 | 3 |
| SLFN12 | ATP6V1B2 | 0.741394 | 3 | 0 | 3 |
| SLFN12 | SLC35A1 | 0.727663 | 3 | 0 | 3 |
| SLFN12 | ZC3H7B | 0.726258 | 3 | 0 | 3 |
| SLFN12 | TMEM165 | 0.721114 | 3 | 0 | 3 |
| SLFN12 | MAP4K3 | 0.720922 | 3 | 0 | 3 |
| SLFN12 | TK2 | 0.713945 | 3 | 0 | 3 |
| SLFN12 | C2orf68 | 0.710562 | 3 | 0 | 3 |
| SLFN12 | PIGV | 0.708002 | 3 | 0 | 3 |
| SLFN12 | NPAT | 0.707289 | 3 | 0 | 3 |
| SLFN12 | GPX1 | 0.7066 | 3 | 0 | 3 |
| SLFN12 | MGAT5 | 0.705982 | 4 | 0 | 4 |
| SLFN12 | ATG7 | 0.705046 | 3 | 0 | 3 |
| SLFN12 | OSBPL9 | 0.704018 | 3 | 0 | 3 |
| SLFN12 | JKAMP | 0.702193 | 4 | 0 | 3 |
| SLFN12 | FBXW2 | 0.701464 | 3 | 0 | 3 |
| SLFN12 | LRRC42 | 0.696646 | 3 | 0 | 3 |
| SLFN12 | AHR | 0.693903 | 3 | 0 | 3 |
For details and further investigation, click here
