| Full name: G protein subunit alpha 14 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q21.2 | ||
| Entrez ID: 9630 | HGNC ID: HGNC:4382 | Ensembl Gene: ENSG00000156049 | OMIM ID: 604397 |
| Drug and gene relationship at DGIdb | |||
GNA14 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa05142 | Chagas disease (American trypanosomiasis) |
Expression of GNA14:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GNA14 | 9630 | 220108_at | -1.2522 | 0.0800 | |
| GSE20347 | GNA14 | 9630 | 220108_at | -0.3385 | 0.0009 | |
| GSE23400 | GNA14 | 9630 | 220108_at | -0.3403 | 0.0000 | |
| GSE26886 | GNA14 | 9630 | 243580_at | -0.5791 | 0.0003 | |
| GSE29001 | GNA14 | 9630 | 220108_at | -0.5056 | 0.0015 | |
| GSE38129 | GNA14 | 9630 | 220108_at | -0.7604 | 0.0000 | |
| GSE45670 | GNA14 | 9630 | 220108_at | -1.6806 | 0.0000 | |
| GSE53622 | GNA14 | 9630 | 102662 | -2.1138 | 0.0000 | |
| GSE53624 | GNA14 | 9630 | 102662 | -2.4545 | 0.0000 | |
| GSE63941 | GNA14 | 9630 | 220108_at | -3.4638 | 0.0000 | |
| GSE77861 | GNA14 | 9630 | 220108_at | -0.4005 | 0.0067 | |
| GSE97050 | GNA14 | 9630 | A_24_P415150 | -0.0660 | 0.8000 | |
| SRP007169 | GNA14 | 9630 | RNAseq | -3.4017 | 0.0000 | |
| SRP064894 | GNA14 | 9630 | RNAseq | -1.3622 | 0.0000 | |
| SRP133303 | GNA14 | 9630 | RNAseq | -2.0115 | 0.0000 | |
| SRP159526 | GNA14 | 9630 | RNAseq | -2.0263 | 0.0000 | |
| SRP193095 | GNA14 | 9630 | RNAseq | -0.9826 | 0.0001 | |
| SRP219564 | GNA14 | 9630 | RNAseq | -1.0355 | 0.2189 | |
| TCGA | GNA14 | 9630 | RNAseq | -1.1065 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by GNA14 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GNA14:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GNA14 | 9630 | 6 | 10 | 14 | |
| GSE20123 | GNA14 | 9630 | 6 | 10 | 14 | |
| GSE43470 | GNA14 | 9630 | 6 | 5 | 32 | |
| GSE46452 | GNA14 | 9630 | 6 | 14 | 39 | |
| GSE47630 | GNA14 | 9630 | 1 | 18 | 21 | |
| GSE54993 | GNA14 | 9630 | 4 | 2 | 64 | |
| GSE54994 | GNA14 | 9630 | 4 | 12 | 37 | |
| GSE60625 | GNA14 | 9630 | 0 | 0 | 11 | |
| GSE74703 | GNA14 | 9630 | 5 | 4 | 27 | |
| GSE74704 | GNA14 | 9630 | 3 | 7 | 10 | |
| TCGA | GNA14 | 9630 | 18 | 29 | 49 |
Total number of gains: 59; Total number of losses: 111; Total Number of normals: 318.
Somatic mutations of GNA14:
Generating mutation plots.
Highly correlated genes for GNA14:
Showing top 20/1619 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GNA14 | ANGPTL1 | 0.814994 | 6 | 0 | 6 |
| GNA14 | CLEC3B | 0.801073 | 3 | 0 | 3 |
| GNA14 | SORBS2 | 0.769361 | 11 | 0 | 11 |
| GNA14 | SYNPO2 | 0.761253 | 6 | 0 | 6 |
| GNA14 | PAQR8 | 0.758718 | 7 | 0 | 7 |
| GNA14 | CYP21A2 | 0.746777 | 3 | 0 | 3 |
| GNA14 | TMEM218 | 0.745468 | 3 | 0 | 3 |
| GNA14 | CGNL1 | 0.74517 | 7 | 0 | 7 |
| GNA14 | LRFN5 | 0.742396 | 5 | 0 | 5 |
| GNA14 | KBTBD3 | 0.739458 | 3 | 0 | 3 |
| GNA14 | FAM3D | 0.736808 | 6 | 0 | 6 |
| GNA14 | NFIX | 0.734077 | 8 | 0 | 8 |
| GNA14 | GPD1L | 0.733809 | 11 | 0 | 11 |
| GNA14 | FAM107A | 0.732431 | 8 | 0 | 8 |
| GNA14 | RSPO2 | 0.731257 | 3 | 0 | 3 |
| GNA14 | CCDC160 | 0.731139 | 4 | 0 | 4 |
| GNA14 | MFAP4 | 0.730449 | 8 | 0 | 8 |
| GNA14 | CCL14 | 0.728768 | 3 | 0 | 3 |
| GNA14 | SORCS1 | 0.727067 | 4 | 0 | 4 |
| GNA14 | CYP4V2 | 0.725315 | 4 | 0 | 4 |
For details and further investigation, click here
