| Full name: hemoglobin subunit zeta | Alias Symbol: HBZ1|HBZ-T1 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 3050 | HGNC ID: HGNC:4835 | Ensembl Gene: ENSG00000130656 | OMIM ID: 142310 |
| Drug and gene relationship at DGIdb | |||
Expression of HBZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HBZ | 3050 | 206647_at | -0.1018 | 0.6918 | |
| GSE20347 | HBZ | 3050 | 206647_at | -0.2526 | 0.0015 | |
| GSE23400 | HBZ | 3050 | 206647_at | -0.2321 | 0.0000 | |
| GSE26886 | HBZ | 3050 | 206647_at | -0.1447 | 0.3189 | |
| GSE29001 | HBZ | 3050 | 206647_at | -0.3647 | 0.0031 | |
| GSE38129 | HBZ | 3050 | 206647_at | -0.3476 | 0.0015 | |
| GSE45670 | HBZ | 3050 | 206647_at | -0.1061 | 0.3068 | |
| GSE63941 | HBZ | 3050 | 206647_at | 0.2822 | 0.0839 | |
| GSE77861 | HBZ | 3050 | 206647_at | -0.2279 | 0.1109 | |
| GSE97050 | HBZ | 3050 | A_33_P3421827 | 0.2218 | 0.2764 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HBZ expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HBZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HBZ | 3050 | 5 | 5 | 20 | |
| GSE20123 | HBZ | 3050 | 5 | 4 | 21 | |
| GSE43470 | HBZ | 3050 | 3 | 7 | 33 | |
| GSE46452 | HBZ | 3050 | 38 | 1 | 20 | |
| GSE47630 | HBZ | 3050 | 13 | 6 | 21 | |
| GSE54993 | HBZ | 3050 | 3 | 5 | 62 | |
| GSE54994 | HBZ | 3050 | 4 | 10 | 39 | |
| GSE60625 | HBZ | 3050 | 4 | 0 | 7 | |
| GSE74703 | HBZ | 3050 | 3 | 5 | 28 | |
| GSE74704 | HBZ | 3050 | 3 | 2 | 15 | |
| TCGA | HBZ | 3050 | 20 | 15 | 61 |
Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.
Somatic mutations of HBZ:
Generating mutation plots.
Highly correlated genes for HBZ:
Showing top 20/802 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HBZ | VPS25 | 0.707688 | 3 | 0 | 3 |
| HBZ | IL2RG | 0.679863 | 3 | 0 | 3 |
| HBZ | FCGR2C | 0.676627 | 3 | 0 | 3 |
| HBZ | SEZ6L | 0.676047 | 4 | 0 | 4 |
| HBZ | DOK1 | 0.6735 | 3 | 0 | 3 |
| HBZ | MYO1E | 0.673485 | 3 | 0 | 3 |
| HBZ | RETSAT | 0.672824 | 4 | 0 | 3 |
| HBZ | SLC44A2 | 0.671362 | 3 | 0 | 3 |
| HBZ | EIF4G2 | 0.666169 | 3 | 0 | 3 |
| HBZ | DUX1 | 0.662165 | 5 | 0 | 5 |
| HBZ | ACOT11 | 0.661795 | 6 | 0 | 5 |
| HBZ | DNTT | 0.66027 | 4 | 0 | 4 |
| HBZ | ART1 | 0.659338 | 4 | 0 | 3 |
| HBZ | MED31 | 0.658355 | 4 | 0 | 4 |
| HBZ | PLEKHA2 | 0.651442 | 3 | 0 | 3 |
| HBZ | DCLK2 | 0.650827 | 4 | 0 | 4 |
| HBZ | GUK1 | 0.64829 | 3 | 0 | 3 |
| HBZ | RARG | 0.646522 | 8 | 0 | 6 |
| HBZ | GK2 | 0.646093 | 4 | 0 | 4 |
| HBZ | CAPZB | 0.645725 | 4 | 0 | 4 |
For details and further investigation, click here
