| Full name: pleckstrin homology domain containing A2 | Alias Symbol: TAPP2 | ||
| Type: protein-coding gene | Cytoband: 8p11.22 | ||
| Entrez ID: 59339 | HGNC ID: HGNC:14336 | Ensembl Gene: ENSG00000169499 | OMIM ID: 607773 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA2 | 59339 | 225136_at | 0.0469 | 0.9225 | |
| GSE20347 | PLEKHA2 | 59339 | 217677_at | 0.0591 | 0.4201 | |
| GSE23400 | PLEKHA2 | 59339 | 217677_at | -0.0964 | 0.0025 | |
| GSE26886 | PLEKHA2 | 59339 | 225136_at | -0.4268 | 0.1312 | |
| GSE29001 | PLEKHA2 | 59339 | 217677_at | 0.2186 | 0.1286 | |
| GSE38129 | PLEKHA2 | 59339 | 217677_at | 0.0036 | 0.9659 | |
| GSE45670 | PLEKHA2 | 59339 | 225136_at | -0.0573 | 0.8010 | |
| GSE53622 | PLEKHA2 | 59339 | 8753 | -0.2743 | 0.0029 | |
| GSE53624 | PLEKHA2 | 59339 | 8753 | -0.3535 | 0.0000 | |
| GSE63941 | PLEKHA2 | 59339 | 225136_at | -0.4060 | 0.5679 | |
| GSE77861 | PLEKHA2 | 59339 | 225136_at | 0.0302 | 0.9325 | |
| GSE97050 | PLEKHA2 | 59339 | A_33_P3339860 | 0.1664 | 0.5756 | |
| SRP007169 | PLEKHA2 | 59339 | RNAseq | -0.7528 | 0.0173 | |
| SRP008496 | PLEKHA2 | 59339 | RNAseq | -0.9298 | 0.0000 | |
| SRP064894 | PLEKHA2 | 59339 | RNAseq | -0.2894 | 0.1772 | |
| SRP133303 | PLEKHA2 | 59339 | RNAseq | 0.0817 | 0.6198 | |
| SRP159526 | PLEKHA2 | 59339 | RNAseq | -0.7965 | 0.0918 | |
| SRP193095 | PLEKHA2 | 59339 | RNAseq | 0.2611 | 0.1331 | |
| SRP219564 | PLEKHA2 | 59339 | RNAseq | -0.3734 | 0.3223 | |
| TCGA | PLEKHA2 | 59339 | RNAseq | 0.0143 | 0.8164 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLEKHA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA2 | 59339 | 10 | 4 | 16 | |
| GSE20123 | PLEKHA2 | 59339 | 10 | 4 | 16 | |
| GSE43470 | PLEKHA2 | 59339 | 8 | 6 | 29 | |
| GSE46452 | PLEKHA2 | 59339 | 20 | 5 | 34 | |
| GSE47630 | PLEKHA2 | 59339 | 12 | 7 | 21 | |
| GSE54993 | PLEKHA2 | 59339 | 2 | 16 | 52 | |
| GSE54994 | PLEKHA2 | 59339 | 16 | 7 | 30 | |
| GSE60625 | PLEKHA2 | 59339 | 3 | 0 | 8 | |
| GSE74703 | PLEKHA2 | 59339 | 8 | 5 | 23 | |
| GSE74704 | PLEKHA2 | 59339 | 9 | 1 | 10 | |
| TCGA | PLEKHA2 | 59339 | 36 | 22 | 38 |
Total number of gains: 134; Total number of losses: 77; Total Number of normals: 277.
Somatic mutations of PLEKHA2:
Generating mutation plots.
Highly correlated genes for PLEKHA2:
Showing top 20/117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA2 | EIF4G2 | 0.807771 | 3 | 0 | 3 |
| PLEKHA2 | LPCAT3 | 0.778545 | 3 | 0 | 3 |
| PLEKHA2 | MTFMT | 0.758522 | 3 | 0 | 3 |
| PLEKHA2 | CDK5R1 | 0.754151 | 3 | 0 | 3 |
| PLEKHA2 | SLC9A8 | 0.73422 | 3 | 0 | 3 |
| PLEKHA2 | TPMT | 0.732365 | 3 | 0 | 3 |
| PLEKHA2 | RNFT1 | 0.723197 | 3 | 0 | 3 |
| PLEKHA2 | PIK3CB | 0.714168 | 3 | 0 | 3 |
| PLEKHA2 | EXOC4 | 0.711791 | 3 | 0 | 3 |
| PLEKHA2 | MVP | 0.704937 | 4 | 0 | 3 |
| PLEKHA2 | LNPEP | 0.699714 | 3 | 0 | 3 |
| PLEKHA2 | RALGAPB | 0.699441 | 3 | 0 | 3 |
| PLEKHA2 | MTA2 | 0.697747 | 3 | 0 | 3 |
| PLEKHA2 | EMP2 | 0.691878 | 3 | 0 | 3 |
| PLEKHA2 | LMBRD2 | 0.69131 | 3 | 0 | 3 |
| PLEKHA2 | SLC30A7 | 0.68949 | 3 | 0 | 3 |
| PLEKHA2 | DTD1 | 0.686248 | 3 | 0 | 3 |
| PLEKHA2 | ELF4 | 0.684602 | 3 | 0 | 3 |
| PLEKHA2 | RAB7A | 0.680521 | 3 | 0 | 3 |
| PLEKHA2 | STK17B | 0.679921 | 3 | 0 | 3 |
For details and further investigation, click here
