| Full name: serpin family E member 1 | Alias Symbol: PAI | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 5054 | HGNC ID: HGNC:8583 | Ensembl Gene: ENSG00000106366 | OMIM ID: 173360 |
| Drug and gene relationship at DGIdb | |||
SERPINE1 involved pathways:
Expression of SERPINE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINE1 | 5054 | 202627_s_at | 1.6575 | 0.1482 | |
| GSE20347 | SERPINE1 | 5054 | 202627_s_at | 2.0959 | 0.0000 | |
| GSE23400 | SERPINE1 | 5054 | 202627_s_at | 1.4179 | 0.0000 | |
| GSE26886 | SERPINE1 | 5054 | 202627_s_at | 2.5142 | 0.0001 | |
| GSE29001 | SERPINE1 | 5054 | 202627_s_at | 1.0634 | 0.0607 | |
| GSE38129 | SERPINE1 | 5054 | 202628_s_at | 1.8304 | 0.0000 | |
| GSE45670 | SERPINE1 | 5054 | 202627_s_at | 1.7210 | 0.0168 | |
| GSE53622 | SERPINE1 | 5054 | 24081 | 2.8283 | 0.0000 | |
| GSE53624 | SERPINE1 | 5054 | 24081 | 3.3439 | 0.0000 | |
| GSE63941 | SERPINE1 | 5054 | 202627_s_at | -3.2298 | 0.0703 | |
| GSE77861 | SERPINE1 | 5054 | 202628_s_at | 1.3197 | 0.0460 | |
| GSE97050 | SERPINE1 | 5054 | A_24_P158089 | 2.4755 | 0.0556 | |
| SRP007169 | SERPINE1 | 5054 | RNAseq | 4.6440 | 0.0000 | |
| SRP008496 | SERPINE1 | 5054 | RNAseq | 5.0964 | 0.0000 | |
| SRP064894 | SERPINE1 | 5054 | RNAseq | 3.2040 | 0.0000 | |
| SRP133303 | SERPINE1 | 5054 | RNAseq | 4.3240 | 0.0000 | |
| SRP159526 | SERPINE1 | 5054 | RNAseq | 2.3267 | 0.0001 | |
| SRP193095 | SERPINE1 | 5054 | RNAseq | 4.7362 | 0.0000 | |
| SRP219564 | SERPINE1 | 5054 | RNAseq | 3.0696 | 0.0000 | |
| TCGA | SERPINE1 | 5054 | RNAseq | 0.3734 | 0.0052 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by SERPINE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINE1 | 5054 | 13 | 0 | 17 | |
| GSE20123 | SERPINE1 | 5054 | 13 | 0 | 17 | |
| GSE43470 | SERPINE1 | 5054 | 7 | 2 | 34 | |
| GSE46452 | SERPINE1 | 5054 | 11 | 1 | 47 | |
| GSE47630 | SERPINE1 | 5054 | 7 | 3 | 30 | |
| GSE54993 | SERPINE1 | 5054 | 1 | 10 | 59 | |
| GSE54994 | SERPINE1 | 5054 | 15 | 3 | 35 | |
| GSE60625 | SERPINE1 | 5054 | 0 | 0 | 11 | |
| GSE74703 | SERPINE1 | 5054 | 7 | 1 | 28 | |
| GSE74704 | SERPINE1 | 5054 | 9 | 0 | 11 | |
| TCGA | SERPINE1 | 5054 | 53 | 6 | 37 |
Total number of gains: 136; Total number of losses: 26; Total Number of normals: 326.
Somatic mutations of SERPINE1:
Generating mutation plots.
Highly correlated genes for SERPINE1:
Showing top 20/1474 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINE1 | TTYH3 | 0.800159 | 7 | 0 | 7 |
| SERPINE1 | MFAP2 | 0.799556 | 11 | 0 | 11 |
| SERPINE1 | FAM89A | 0.786792 | 3 | 0 | 3 |
| SERPINE1 | ADAMTS12 | 0.785285 | 8 | 0 | 8 |
| SERPINE1 | LOXL2 | 0.779964 | 12 | 0 | 12 |
| SERPINE1 | PEAR1 | 0.777966 | 3 | 0 | 3 |
| SERPINE1 | LAMC2 | 0.763546 | 12 | 0 | 12 |
| SERPINE1 | ALPK2 | 0.759598 | 3 | 0 | 3 |
| SERPINE1 | TNFRSF12A | 0.755775 | 13 | 0 | 13 |
| SERPINE1 | XPR1 | 0.751781 | 7 | 0 | 7 |
| SERPINE1 | WDR54 | 0.750287 | 7 | 0 | 7 |
| SERPINE1 | PLAUR | 0.748561 | 13 | 0 | 13 |
| SERPINE1 | ZNF469 | 0.746454 | 8 | 0 | 8 |
| SERPINE1 | COL5A1 | 0.745387 | 12 | 0 | 12 |
| SERPINE1 | SPON2 | 0.738937 | 3 | 0 | 3 |
| SERPINE1 | FAP | 0.737746 | 11 | 0 | 10 |
| SERPINE1 | MICAL1 | 0.734088 | 3 | 0 | 3 |
| SERPINE1 | HIC1 | 0.732398 | 4 | 0 | 4 |
| SERPINE1 | INHBA | 0.731582 | 13 | 0 | 12 |
| SERPINE1 | PLAU | 0.731489 | 13 | 0 | 12 |
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