HIF1A

 

Full name: hypoxia inducible factor 1 subunit alpha Alias Symbol: MOP1|HIF-1alpha|PASD8|HIF1|bHLHe78
Type: protein-coding gene Cytoband: 14q23.2
Entrez ID: 3091 HGNC ID: HGNC:4910 Ensembl Gene: ENSG00000100644 OMIM ID: 603348
Drug and gene relationship at DGIdb

 

HIF1A involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05231Choline metabolism in cancer

 

Expression of HIF1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HIF1A 3091 200989_at 0.0163 0.9806
GSE20347 HIF1A 3091 200989_at 0.1015 0.5893
GSE23400 HIF1A 3091 200989_at 0.4301 0.0000
GSE26886 HIF1A 3091 200989_at 0.3693 0.0648
GSE29001 HIF1A 3091 200989_at 0.2892 0.2520
GSE38129 HIF1A 3091 200989_at 0.2173 0.0941
GSE45670 HIF1A 3091 200989_at 0.2030 0.2108
GSE53622 HIF1A 3091 19494 0.6505 0.0000
GSE53624 HIF1A 3091 19494 0.4590 0.0000
GSE63941 HIF1A 3091 200989_at -0.8638 0.0106
GSE77861 HIF1A 3091 200989_at 0.2342 0.2972
GSE97050 HIF1A 3091 A_33_P3231277 0.7978 0.0970
SRP007169 HIF1A 3091 RNAseq -0.4459 0.1514
SRP008496 HIF1A 3091 RNAseq 0.0449 0.8522
SRP064894 HIF1A 3091 RNAseq 0.7665 0.1325
SRP133303 HIF1A 3091 RNAseq 0.9253 0.0036
SRP159526 HIF1A 3091 RNAseq 0.1355 0.7758
SRP193095 HIF1A 3091 RNAseq 0.8107 0.0000
SRP219564 HIF1A 3091 RNAseq 0.8590 0.1435
TCGA HIF1A 3091 RNAseq 0.2471 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by HIF1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HIF1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HIF1A 3091 9 3 18
GSE20123 HIF1A 3091 9 3 18
GSE43470 HIF1A 3091 8 2 33
GSE46452 HIF1A 3091 16 3 40
GSE47630 HIF1A 3091 11 9 20
GSE54993 HIF1A 3091 3 9 58
GSE54994 HIF1A 3091 19 4 30
GSE60625 HIF1A 3091 0 2 9
GSE74703 HIF1A 3091 7 2 27
GSE74704 HIF1A 3091 4 2 14
TCGA HIF1A 3091 33 14 49

Total number of gains: 119; Total number of losses: 53; Total Number of normals: 316.  

 

Somatic mutations of HIF1A:

 

Generating mutation plots.

 

Highly correlated genes for HIF1A:

 

Showing top 20/392 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HIF1ASERPINB90.771792303
HIF1AING20.724315303
HIF1ALPIN30.722415303
HIF1ATMEM184C0.718569303
HIF1AHAS30.717078303
HIF1ARNF1450.717005303
HIF1ASHPK0.714079303
HIF1ACPSF30.713554303
HIF1ARAD210.711839303
HIF1AALDH1L20.709643303
HIF1ADPP90.706583303
HIF1ADISP20.706373303
HIF1AARSK0.703191303
HIF1ASMU10.6965303
HIF1ASP30.696064404
HIF1ADHX150.69555404
HIF1ABRD40.690986404
HIF1APCSK50.689592303
HIF1AWDR360.683457303
HIF1AMRPL450.682963303

For details and further investigation, click here