| Full name: sedoheptulokinase | Alias Symbol: SHK | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 23729 | HGNC ID: HGNC:1492 | Ensembl Gene: ENSG00000197417 | OMIM ID: 605060 |
| Drug and gene relationship at DGIdb | |||
Expression of SHPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHPK | 23729 | 219713_at | -0.0232 | 0.9497 | |
| GSE20347 | SHPK | 23729 | 219713_at | 0.0959 | 0.3214 | |
| GSE23400 | SHPK | 23729 | 219713_at | -0.0596 | 0.0906 | |
| GSE26886 | SHPK | 23729 | 219713_at | 0.3544 | 0.0366 | |
| GSE29001 | SHPK | 23729 | 219713_at | -0.1710 | 0.3747 | |
| GSE38129 | SHPK | 23729 | 219713_at | 0.1197 | 0.2858 | |
| GSE45670 | SHPK | 23729 | 219713_at | -0.0381 | 0.8341 | |
| GSE53622 | SHPK | 23729 | 45524 | 0.0371 | 0.7304 | |
| GSE53624 | SHPK | 23729 | 45524 | -0.0845 | 0.2609 | |
| GSE63941 | SHPK | 23729 | 219713_at | -0.1647 | 0.6136 | |
| GSE77861 | SHPK | 23729 | 219713_at | -0.1495 | 0.2839 | |
| GSE97050 | SHPK | 23729 | A_23_P310350 | 0.1855 | 0.5076 | |
| SRP007169 | SHPK | 23729 | RNAseq | -0.1351 | 0.7729 | |
| SRP008496 | SHPK | 23729 | RNAseq | 0.2269 | 0.4892 | |
| SRP064894 | SHPK | 23729 | RNAseq | -0.0374 | 0.8159 | |
| SRP133303 | SHPK | 23729 | RNAseq | -0.1203 | 0.5229 | |
| SRP159526 | SHPK | 23729 | RNAseq | -0.1666 | 0.5320 | |
| SRP193095 | SHPK | 23729 | RNAseq | 0.1189 | 0.2958 | |
| SRP219564 | SHPK | 23729 | RNAseq | 0.4582 | 0.2963 | |
| TCGA | SHPK | 23729 | RNAseq | -0.0843 | 0.1338 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SHPK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHPK | 23729 | 5 | 3 | 22 | |
| GSE20123 | SHPK | 23729 | 5 | 4 | 21 | |
| GSE43470 | SHPK | 23729 | 1 | 6 | 36 | |
| GSE46452 | SHPK | 23729 | 34 | 1 | 24 | |
| GSE47630 | SHPK | 23729 | 7 | 1 | 32 | |
| GSE54993 | SHPK | 23729 | 4 | 3 | 63 | |
| GSE54994 | SHPK | 23729 | 5 | 9 | 39 | |
| GSE60625 | SHPK | 23729 | 4 | 0 | 7 | |
| GSE74703 | SHPK | 23729 | 1 | 3 | 32 | |
| GSE74704 | SHPK | 23729 | 3 | 2 | 15 | |
| TCGA | SHPK | 23729 | 17 | 21 | 58 |
Total number of gains: 86; Total number of losses: 53; Total Number of normals: 349.
Somatic mutations of SHPK:
Generating mutation plots.
Highly correlated genes for SHPK:
Showing top 20/200 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHPK | HIF1A | 0.714079 | 3 | 0 | 3 |
| SHPK | MAPK6 | 0.681261 | 3 | 0 | 3 |
| SHPK | RNF208 | 0.677933 | 3 | 0 | 3 |
| SHPK | YWHAE | 0.662625 | 4 | 0 | 4 |
| SHPK | ALDOA | 0.662618 | 3 | 0 | 3 |
| SHPK | GJA3 | 0.662022 | 4 | 0 | 4 |
| SHPK | USP3 | 0.661243 | 3 | 0 | 3 |
| SHPK | FAM83A | 0.652621 | 4 | 0 | 3 |
| SHPK | JAG1 | 0.650094 | 5 | 0 | 4 |
| SHPK | TAX1BP3 | 0.646307 | 3 | 0 | 3 |
| SHPK | KRT37 | 0.646286 | 3 | 0 | 3 |
| SHPK | MRPL44 | 0.644848 | 4 | 0 | 4 |
| SHPK | ZFC3H1 | 0.64222 | 3 | 0 | 3 |
| SHPK | CANT1 | 0.640929 | 3 | 0 | 3 |
| SHPK | MIPEP | 0.635646 | 3 | 0 | 3 |
| SHPK | UGCG | 0.634231 | 4 | 0 | 4 |
| SHPK | NOL12 | 0.634084 | 3 | 0 | 3 |
| SHPK | PPP4C | 0.633188 | 5 | 0 | 5 |
| SHPK | CHCHD5 | 0.633066 | 3 | 0 | 3 |
| SHPK | FAM110C | 0.630751 | 4 | 0 | 3 |
For details and further investigation, click here
