| Full name: bromodomain containing 4 | Alias Symbol: HUNKI|MCAP|CAP|HUNK1 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 23476 | HGNC ID: HGNC:13575 | Ensembl Gene: ENSG00000141867 | OMIM ID: 608749 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BRD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRD4 | 23476 | 226052_at | 0.2353 | 0.3617 | |
| GSE20347 | BRD4 | 23476 | 202102_s_at | 0.1980 | 0.1353 | |
| GSE23400 | BRD4 | 23476 | 202102_s_at | 0.3173 | 0.0036 | |
| GSE26886 | BRD4 | 23476 | 226052_at | 0.5828 | 0.0025 | |
| GSE29001 | BRD4 | 23476 | 202102_s_at | 0.3509 | 0.2450 | |
| GSE38129 | BRD4 | 23476 | 202102_s_at | 0.2609 | 0.2641 | |
| GSE45670 | BRD4 | 23476 | 202102_s_at | 0.3615 | 0.0098 | |
| GSE53622 | BRD4 | 23476 | 70743 | 0.4128 | 0.0000 | |
| GSE53624 | BRD4 | 23476 | 70743 | 0.6827 | 0.0000 | |
| GSE63941 | BRD4 | 23476 | 226052_at | 0.7071 | 0.0353 | |
| GSE77861 | BRD4 | 23476 | 226052_at | 0.3251 | 0.0329 | |
| GSE97050 | BRD4 | 23476 | A_33_P3373745 | -0.0515 | 0.8186 | |
| SRP007169 | BRD4 | 23476 | RNAseq | 0.6239 | 0.1934 | |
| SRP008496 | BRD4 | 23476 | RNAseq | 0.7796 | 0.0171 | |
| SRP064894 | BRD4 | 23476 | RNAseq | 0.2029 | 0.2267 | |
| SRP133303 | BRD4 | 23476 | RNAseq | 0.1333 | 0.3907 | |
| SRP159526 | BRD4 | 23476 | RNAseq | 0.2780 | 0.3053 | |
| SRP193095 | BRD4 | 23476 | RNAseq | 0.4142 | 0.0023 | |
| SRP219564 | BRD4 | 23476 | RNAseq | 0.4190 | 0.1699 | |
| TCGA | BRD4 | 23476 | RNAseq | 0.0831 | 0.0447 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BRD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRD4 | 23476 | 4 | 2 | 24 | |
| GSE20123 | BRD4 | 23476 | 3 | 1 | 26 | |
| GSE43470 | BRD4 | 23476 | 2 | 6 | 35 | |
| GSE46452 | BRD4 | 23476 | 47 | 1 | 11 | |
| GSE47630 | BRD4 | 23476 | 4 | 7 | 29 | |
| GSE54993 | BRD4 | 23476 | 15 | 4 | 51 | |
| GSE54994 | BRD4 | 23476 | 6 | 13 | 34 | |
| GSE60625 | BRD4 | 23476 | 9 | 0 | 2 | |
| GSE74703 | BRD4 | 23476 | 2 | 4 | 30 | |
| GSE74704 | BRD4 | 23476 | 0 | 1 | 19 | |
| TCGA | BRD4 | 23476 | 19 | 12 | 65 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of BRD4:
Generating mutation plots.
Highly correlated genes for BRD4:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRD4 | SIPA1L2 | 0.849341 | 3 | 0 | 3 |
| BRD4 | EXOC8 | 0.796828 | 3 | 0 | 3 |
| BRD4 | ZNF567 | 0.757836 | 3 | 0 | 3 |
| BRD4 | NDUFB4 | 0.745228 | 3 | 0 | 3 |
| BRD4 | RPL22L1 | 0.740628 | 3 | 0 | 3 |
| BRD4 | NACC1 | 0.738817 | 5 | 0 | 5 |
| BRD4 | DNTTIP1 | 0.73793 | 3 | 0 | 3 |
| BRD4 | SPIRE2 | 0.723797 | 4 | 0 | 4 |
| BRD4 | CORO1C | 0.721153 | 4 | 0 | 4 |
| BRD4 | SFMBT1 | 0.718252 | 3 | 0 | 3 |
| BRD4 | ZNF260 | 0.716942 | 3 | 0 | 3 |
| BRD4 | RAB7A | 0.714633 | 3 | 0 | 3 |
| BRD4 | DSCC1 | 0.710617 | 3 | 0 | 3 |
| BRD4 | RICTOR | 0.70863 | 3 | 0 | 3 |
| BRD4 | PPP6R3 | 0.703917 | 3 | 0 | 3 |
| BRD4 | ZNF518B | 0.703516 | 3 | 0 | 3 |
| BRD4 | ALKBH6 | 0.702264 | 6 | 0 | 5 |
| BRD4 | SEC16A | 0.698953 | 7 | 0 | 6 |
| BRD4 | LINGO1 | 0.696585 | 3 | 0 | 3 |
| BRD4 | PITPNB | 0.694769 | 3 | 0 | 3 |
For details and further investigation, click here
