HLA-A

 

Full name: major histocompatibility complex, class I, A Alias Symbol: 
Type: protein-coding gene Cytoband: 6p22.1
Entrez ID: 3105 HGNC ID: HGNC:4931 Ensembl Gene: ENSG00000206503 OMIM ID: 142800
Related drugs: CARBAMAZEPINE... [more]
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 9/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

HLA-A involved pathways:

KEGG pathway Description View
hsa04612Antigen processing and presentation
hsa04650Natural killer cell mediated cytotoxicity
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection

 

Expression of HLA-A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HLA-A 3105 215313_x_at 0.3896 0.4767
GSE20347 HLA-A 3105 213932_x_at 0.3887 0.0211
GSE23400 HLA-A 3105 213932_x_at 0.4143 0.0000
GSE26886 HLA-A 3105 213932_x_at 0.4681 0.0236
GSE29001 HLA-A 3105 213932_x_at 0.4008 0.0165
GSE38129 HLA-A 3105 215313_x_at 0.4910 0.0042
GSE45670 HLA-A 3105 213932_x_at 0.5971 0.0047
GSE53622 HLA-A 3105 73247 1.1546 0.0000
GSE53624 HLA-A 3105 73247 0.8413 0.0000
GSE63941 HLA-A 3105 215313_x_at 0.5538 0.3658
GSE77861 HLA-A 3105 215313_x_at 0.6458 0.0274
GSE97050 HLA-A 3105 A_33_P3237574 0.8004 0.1512
SRP007169 HLA-A 3105 RNAseq 0.8182 0.3209
SRP008496 HLA-A 3105 RNAseq 0.7580 0.1317
SRP064894 HLA-A 3105 RNAseq 1.2172 0.0000
SRP133303 HLA-A 3105 RNAseq 0.9462 0.0060
SRP159526 HLA-A 3105 RNAseq 0.3822 0.3546
SRP193095 HLA-A 3105 RNAseq 0.3973 0.1281
SRP219564 HLA-A 3105 RNAseq 1.4786 0.0190
TCGA HLA-A 3105 RNAseq 0.1405 0.0505

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by HLA-A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HLA-A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HLA-A 3105 3 1 26
GSE20123 HLA-A 3105 3 1 26
GSE43470 HLA-A 3105 5 0 38
GSE46452 HLA-A 3105 1 10 48
GSE47630 HLA-A 3105 7 4 29
GSE54993 HLA-A 3105 2 1 67
GSE54994 HLA-A 3105 11 4 38
GSE60625 HLA-A 3105 0 1 10
GSE74703 HLA-A 3105 5 0 31
GSE74704 HLA-A 3105 1 0 19

Total number of gains: 38; Total number of losses: 22; Total Number of normals: 332.  

 

Somatic mutations of HLA-A:

 

Generating mutation plots.

 

Highly correlated genes for HLA-A:

 

Showing top 20/1181 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HLA-AHLA-F0.89876313013
HLA-AHLA-B0.8642813013
HLA-AHLA-C0.85753813013
HLA-AHLA-G0.83165413013
HLA-ACD800.785107303
HLA-APSMB90.76149212011
HLA-ARASAL30.746255303
HLA-AUSP410.745942303
HLA-ATAP10.74194111010
HLA-ATMEM200A0.714614404
HLA-AUBE2L60.71179813012
HLA-AB2M0.71177912012
HLA-ADCBLD10.70444505
HLA-APREX10.702962403
HLA-APSMB80.70217713012
HLA-ATMC80.697371403
HLA-ASTAT10.69685611010
HLA-AWDR810.695531403
HLA-ABTN3A30.693867908
HLA-ASUSD30.693587403

For details and further investigation, click here