| Full name: major histocompatibility complex, class I, F | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.1 | ||
| Entrez ID: 3134 | HGNC ID: HGNC:4963 | Ensembl Gene: ENSG00000204642 | OMIM ID: 143110 |
| Drug and gene relationship at DGIdb | |||
HLA-F involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05166 | HTLV-I infection | |
| hsa05169 | Epstein-Barr virus infection |
Expression of HLA-F:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-F | 3134 | 221875_x_at | 0.5598 | 0.4729 | |
| GSE20347 | HLA-F | 3134 | 221875_x_at | 0.4739 | 0.0985 | |
| GSE23400 | HLA-F | 3134 | 221875_x_at | 0.6551 | 0.0000 | |
| GSE26886 | HLA-F | 3134 | 221875_x_at | 0.5895 | 0.1670 | |
| GSE29001 | HLA-F | 3134 | 221875_x_at | 0.8740 | 0.0002 | |
| GSE38129 | HLA-F | 3134 | 221875_x_at | 0.4928 | 0.0330 | |
| GSE45670 | HLA-F | 3134 | 221875_x_at | 0.6970 | 0.0403 | |
| GSE53622 | HLA-F | 3134 | 13316 | 0.9327 | 0.0000 | |
| GSE53624 | HLA-F | 3134 | 13316 | 0.8737 | 0.0000 | |
| GSE63941 | HLA-F | 3134 | 221875_x_at | 1.3658 | 0.0928 | |
| GSE77861 | HLA-F | 3134 | 221875_x_at | 0.5243 | 0.0551 | |
| GSE97050 | HLA-F | 3134 | A_33_P3379939 | 0.4542 | 0.3442 | |
| SRP007169 | HLA-F | 3134 | RNAseq | 1.1510 | 0.0630 | |
| SRP008496 | HLA-F | 3134 | RNAseq | 1.2477 | 0.0030 | |
| SRP064894 | HLA-F | 3134 | RNAseq | 1.0999 | 0.0000 | |
| SRP133303 | HLA-F | 3134 | RNAseq | 0.9156 | 0.0001 | |
| SRP159526 | HLA-F | 3134 | RNAseq | 0.1927 | 0.7615 | |
| SRP193095 | HLA-F | 3134 | RNAseq | 0.8800 | 0.0067 | |
| SRP219564 | HLA-F | 3134 | RNAseq | 1.5970 | 0.0008 | |
| TCGA | HLA-F | 3134 | RNAseq | 0.2711 | 0.0351 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HLA-F expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-F:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-F | 3134 | 2 | 1 | 27 | |
| GSE20123 | HLA-F | 3134 | 2 | 1 | 27 | |
| GSE43470 | HLA-F | 3134 | 5 | 0 | 38 | |
| GSE46452 | HLA-F | 3134 | 1 | 10 | 48 | |
| GSE47630 | HLA-F | 3134 | 7 | 4 | 29 | |
| GSE54993 | HLA-F | 3134 | 2 | 1 | 67 | |
| GSE54994 | HLA-F | 3134 | 11 | 4 | 38 | |
| GSE60625 | HLA-F | 3134 | 0 | 1 | 10 | |
| GSE74703 | HLA-F | 3134 | 5 | 0 | 31 | |
| GSE74704 | HLA-F | 3134 | 0 | 0 | 20 |
Total number of gains: 35; Total number of losses: 22; Total Number of normals: 335.
Somatic mutations of HLA-F:
Generating mutation plots.
Highly correlated genes for HLA-F:
Showing top 20/655 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-F | HLA-A | 0.898763 | 13 | 0 | 13 |
| HLA-F | HLA-B | 0.892463 | 13 | 0 | 13 |
| HLA-F | HLA-C | 0.85672 | 13 | 0 | 13 |
| HLA-F | HLA-G | 0.855097 | 13 | 0 | 12 |
| HLA-F | PSMB9 | 0.788702 | 12 | 0 | 11 |
| HLA-F | TAP1 | 0.78194 | 10 | 0 | 10 |
| HLA-F | PSMB8 | 0.772904 | 12 | 0 | 12 |
| HLA-F | UBE2L6 | 0.759982 | 13 | 0 | 13 |
| HLA-F | BTN3A3 | 0.735412 | 9 | 0 | 8 |
| HLA-F | IFI35 | 0.734711 | 13 | 0 | 13 |
| HLA-F | EPSTI1 | 0.716472 | 8 | 0 | 6 |
| HLA-F | BTN3A1 | 0.71147 | 12 | 0 | 10 |
| HLA-F | BTN3A2 | 0.710697 | 12 | 0 | 10 |
| HLA-F | PSMB10 | 0.706707 | 11 | 0 | 10 |
| HLA-F | PSMB8-AS1 | 0.704106 | 7 | 0 | 6 |
| HLA-F | HCP5 | 0.703944 | 12 | 0 | 11 |
| HLA-F | RBM12B | 0.696526 | 3 | 0 | 3 |
| HLA-F | IFI44 | 0.693691 | 12 | 0 | 11 |
| HLA-F | CXCL11 | 0.679276 | 11 | 0 | 9 |
| HLA-F | PARP14 | 0.678181 | 9 | 0 | 8 |
For details and further investigation, click here
