Full name: beta-2-microglobulin	Alias Symbol:
Type: protein-coding gene	Cytoband: 15q21.1
Entrez ID: 567	HGNC ID: HGNC:914	Ensembl Gene: ENSG00000166710	OMIM ID: 109700
Drug and gene relationship at DGIdb
Screen Evidence: This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of B2M:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	B2M	567	201891_s_at	0.0996	0.7016	Show
GSE20347	B2M	567	201891_s_at	0.3062	0.0161	Show
GSE23400	B2M	567	201891_s_at	0.2471	0.0009	Show
GSE26886	B2M	567	201891_s_at	0.0327	0.8699	Show
GSE29001	B2M	567	201891_s_at	0.1404	0.2100	Show
GSE38129	B2M	567	201891_s_at	0.1498	0.0803	Show
GSE45670	B2M	567	201891_s_at	0.2570	0.0089	Show
GSE53622	B2M	567	11624	1.3041	0.0000	Show
GSE53624	B2M	567	11624	1.0874	0.0000	Show
GSE63941	B2M	567	216231_s_at	-0.3632	0.3793	Show
GSE77861	B2M	567	216231_s_at	0.2137	0.4472	Show
GSE97050	B2M	567	A_23_P37441	0.9015	0.1134	Show
SRP007169	B2M	567	RNAseq	0.5536	0.1931	Show
SRP008496	B2M	567	RNAseq	0.4885	0.1101	Show
SRP064894	B2M	567	RNAseq	0.7599	0.0004	Show
SRP133303	B2M	567	RNAseq	0.6952	0.0021	Show
SRP159526	B2M	567	RNAseq	0.0034	0.9957	Show
SRP193095	B2M	567	RNAseq	0.0202	0.9337	Show
SRP219564	B2M	567	RNAseq	0.7911	0.1324	Show
TCGA	B2M	567	RNAseq	0.0928	0.1088	Show

Upregulated datasets: 2; Downregulated datasets: 0.  Download Data

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Survival by B2M expression:

 

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Copy number change of B2M:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	B2M	567	3	4	23	Show
GSE20123	B2M	567	3	5	22	Show
GSE43470	B2M	567	4	4	35	Show
GSE46452	B2M	567	3	7	49	Show
GSE47630	B2M	567	8	10	22	Show
GSE54993	B2M	567	4	6	60	Show
GSE54994	B2M	567	5	7	41	Show
GSE60625	B2M	567	4	0	7	Show
GSE74703	B2M	567	4	3	29	Show
GSE74704	B2M	567	1	2	17	Show
TCGA	B2M	567	12	16	68	Show

Total number of gains: 51; Total number of losses: 64; Total Number of normals: 373.  Download Data

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Somatic mutations of B2M:

 

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Highly correlated genes for B2M:

 

Showing top 20/415 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
B2M	HLA-C	0.735678	12	0	12
B2M	HLA-B	0.733456	12	0	12
B2M	HLA-A	0.711779	12	0	12
B2M	FNDC1	0.703508	3	0	3
B2M	RNF213	0.698107	3	0	3
B2M	PDIA3	0.683373	4	0	4
B2M	USP41	0.665603	3	0	3
B2M	EPSTI1	0.662903	8	0	8
B2M	PDIA5	0.662868	3	0	3
B2M	HLA-F	0.659445	13	0	11
B2M	PSMB9	0.655035	11	0	10
B2M	DDX60	0.654114	13	0	12
B2M	TAP1	0.650635	11	0	11
B2M	RUNX2	0.645989	6	0	5
B2M	STAT1	0.644219	13	0	12
B2M	IFI44	0.643645	13	0	13
B2M	BTN3A3	0.638587	9	0	8
B2M	IFIH1	0.635909	11	0	8
B2M	ZNF469	0.634108	4	0	3
B2M	TTYH3	0.632911	5	0	4

For details and further investigation, click here