| Full name: major histocompatibility complex, class I, B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 3106 | HGNC ID: HGNC:4932 | Ensembl Gene: ENSG00000234745 | OMIM ID: 142830 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HLA-B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa05166 | HTLV-I infection | |
| hsa05169 | Epstein-Barr virus infection |
Expression of HLA-B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-B | 3106 | 209140_x_at | 0.4880 | 0.2743 | |
| GSE20347 | HLA-B | 3106 | 209140_x_at | 0.4695 | 0.1011 | |
| GSE23400 | HLA-B | 3106 | 209140_x_at | 0.5490 | 0.0000 | |
| GSE26886 | HLA-B | 3106 | 209140_x_at | 0.2514 | 0.5360 | |
| GSE29001 | HLA-B | 3106 | 209140_x_at | 0.8216 | 0.0016 | |
| GSE38129 | HLA-B | 3106 | 209140_x_at | 0.5140 | 0.0167 | |
| GSE45670 | HLA-B | 3106 | 209140_x_at | 0.6041 | 0.0354 | |
| GSE53622 | HLA-B | 3106 | 150977 | 0.9199 | 0.0000 | |
| GSE53624 | HLA-B | 3106 | 53512 | 0.9768 | 0.0000 | |
| GSE63941 | HLA-B | 3106 | 209140_x_at | 0.7910 | 0.3779 | |
| GSE77861 | HLA-B | 3106 | 209140_x_at | 0.5171 | 0.1199 | |
| GSE97050 | HLA-B | 3106 | A_33_P3424800 | 0.9893 | 0.0964 | |
| SRP007169 | HLA-B | 3106 | RNAseq | 0.8268 | 0.1344 | |
| SRP008496 | HLA-B | 3106 | RNAseq | 0.5039 | 0.1799 | |
| SRP064894 | HLA-B | 3106 | RNAseq | 1.3527 | 0.0000 | |
| SRP133303 | HLA-B | 3106 | RNAseq | 1.1263 | 0.0053 | |
| SRP159526 | HLA-B | 3106 | RNAseq | 0.6171 | 0.4125 | |
| SRP193095 | HLA-B | 3106 | RNAseq | 0.8360 | 0.0011 | |
| SRP219564 | HLA-B | 3106 | RNAseq | 1.3800 | 0.0255 | |
| TCGA | HLA-B | 3106 | RNAseq | 0.2181 | 0.0084 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HLA-B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-B | 3106 | 5 | 1 | 24 | |
| GSE20123 | HLA-B | 3106 | 5 | 1 | 24 | |
| GSE43470 | HLA-B | 3106 | 5 | 1 | 37 | |
| GSE46452 | HLA-B | 3106 | 1 | 10 | 48 | |
| GSE47630 | HLA-B | 3106 | 7 | 3 | 30 | |
| GSE54993 | HLA-B | 3106 | 2 | 1 | 67 | |
| GSE54994 | HLA-B | 3106 | 11 | 4 | 38 | |
| GSE60625 | HLA-B | 3106 | 0 | 1 | 10 | |
| GSE74703 | HLA-B | 3106 | 5 | 0 | 31 | |
| GSE74704 | HLA-B | 3106 | 2 | 0 | 18 |
Total number of gains: 43; Total number of losses: 22; Total Number of normals: 327.
Somatic mutations of HLA-B:
Generating mutation plots.
Highly correlated genes for HLA-B:
Showing top 20/476 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-B | HLA-C | 0.941252 | 13 | 0 | 13 |
| HLA-B | HLA-F | 0.892463 | 13 | 0 | 13 |
| HLA-B | HLA-A | 0.86428 | 13 | 0 | 13 |
| HLA-B | HLA-G | 0.851031 | 13 | 0 | 13 |
| HLA-B | PSMB9 | 0.782276 | 13 | 0 | 13 |
| HLA-B | UBE2L6 | 0.747333 | 13 | 0 | 13 |
| HLA-B | B2M | 0.733456 | 12 | 0 | 12 |
| HLA-B | PSMB8 | 0.711874 | 13 | 0 | 12 |
| HLA-B | TAP1 | 0.695931 | 11 | 0 | 9 |
| HLA-B | BTN3A3 | 0.694742 | 10 | 0 | 9 |
| HLA-B | PARP14 | 0.684595 | 8 | 0 | 8 |
| HLA-B | HCP5 | 0.678959 | 12 | 0 | 12 |
| HLA-B | AGTRAP | 0.669215 | 3 | 0 | 3 |
| HLA-B | RNF166 | 0.66347 | 3 | 0 | 3 |
| HLA-B | TAPBP | 0.661876 | 12 | 0 | 10 |
| HLA-B | HLA-E | 0.659786 | 11 | 0 | 10 |
| HLA-B | BTN3A2 | 0.659324 | 12 | 0 | 9 |
| HLA-B | IFI35 | 0.657986 | 13 | 0 | 12 |
| HLA-B | PSMB10 | 0.656023 | 11 | 0 | 9 |
| HLA-B | NMI | 0.651361 | 12 | 0 | 10 |
For details and further investigation, click here
