| Full name: major histocompatibility complex, class I, G | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.1 | ||
| Entrez ID: 3135 | HGNC ID: HGNC:4964 | Ensembl Gene: ENSG00000204632 | OMIM ID: 142871 |
| Drug and gene relationship at DGIdb | |||
HLA-G involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity | |
| hsa05166 | HTLV-I infection | |
| hsa05169 | Epstein-Barr virus infection |
Expression of HLA-G:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-G | 3135 | 211528_x_at | 0.3224 | 0.5883 | |
| GSE20347 | HLA-G | 3135 | 211529_x_at | 0.1240 | 0.6778 | |
| GSE23400 | HLA-G | 3135 | 211529_x_at | 0.3322 | 0.0014 | |
| GSE26886 | HLA-G | 3135 | 211529_x_at | -0.0486 | 0.9142 | |
| GSE29001 | HLA-G | 3135 | 211529_x_at | 0.4734 | 0.0733 | |
| GSE38129 | HLA-G | 3135 | 211529_x_at | 0.2969 | 0.1637 | |
| GSE45670 | HLA-G | 3135 | 211528_x_at | 0.4042 | 0.1087 | |
| GSE53622 | HLA-G | 3135 | 30769 | 0.9394 | 0.0000 | |
| GSE53624 | HLA-G | 3135 | 30769 | 0.8448 | 0.0000 | |
| GSE63941 | HLA-G | 3135 | 211528_x_at | 1.1845 | 0.0391 | |
| GSE77861 | HLA-G | 3135 | 211528_x_at | 0.2824 | 0.2877 | |
| GSE97050 | HLA-G | 3135 | A_24_P311926 | 0.5673 | 0.2395 | |
| SRP007169 | HLA-G | 3135 | RNAseq | 0.2851 | 0.6948 | |
| SRP008496 | HLA-G | 3135 | RNAseq | 0.8603 | 0.0913 | |
| TCGA | HLA-G | 3135 | RNAseq | 0.7611 | 0.0807 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HLA-G expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-G:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-G | 3135 | 3 | 1 | 26 | |
| GSE20123 | HLA-G | 3135 | 3 | 1 | 26 | |
| GSE43470 | HLA-G | 3135 | 5 | 0 | 38 | |
| GSE46452 | HLA-G | 3135 | 1 | 10 | 48 | |
| GSE47630 | HLA-G | 3135 | 7 | 4 | 29 | |
| GSE54993 | HLA-G | 3135 | 2 | 1 | 67 | |
| GSE54994 | HLA-G | 3135 | 11 | 4 | 38 | |
| GSE60625 | HLA-G | 3135 | 0 | 1 | 10 | |
| GSE74703 | HLA-G | 3135 | 5 | 0 | 31 | |
| GSE74704 | HLA-G | 3135 | 1 | 0 | 19 |
Total number of gains: 38; Total number of losses: 22; Total Number of normals: 332.
Somatic mutations of HLA-G:
Generating mutation plots.
Highly correlated genes for HLA-G:
Showing top 20/421 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-G | HLA-F | 0.855097 | 13 | 0 | 12 |
| HLA-G | HLA-B | 0.851031 | 13 | 0 | 13 |
| HLA-G | HLA-A | 0.831654 | 13 | 0 | 13 |
| HLA-G | HLA-C | 0.829265 | 13 | 0 | 13 |
| HLA-G | TIGIT | 0.790548 | 3 | 0 | 3 |
| HLA-G | USP41 | 0.701204 | 3 | 0 | 3 |
| HLA-G | PSMB8 | 0.696975 | 11 | 0 | 9 |
| HLA-G | PSMB9 | 0.687489 | 11 | 0 | 9 |
| HLA-G | TAP1 | 0.681351 | 10 | 0 | 8 |
| HLA-G | DDX60L | 0.67883 | 4 | 0 | 3 |
| HLA-G | SPOCK2 | 0.672813 | 3 | 0 | 3 |
| HLA-G | BIN2 | 0.667554 | 3 | 0 | 3 |
| HLA-G | HCP5 | 0.667298 | 10 | 0 | 9 |
| HLA-G | ITGAM | 0.663373 | 3 | 0 | 3 |
| HLA-G | C1QC | 0.662533 | 5 | 0 | 3 |
| HLA-G | RNF213 | 0.660933 | 4 | 0 | 3 |
| HLA-G | UBE2L6 | 0.6586 | 12 | 0 | 10 |
| HLA-G | RPS4X | 0.657394 | 3 | 0 | 3 |
| HLA-G | BTN3A2 | 0.656089 | 12 | 0 | 10 |
| HLA-G | AIF1 | 0.654817 | 7 | 0 | 5 |
For details and further investigation, click here
