| Full name: major histocompatibility complex, class II, DO beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3112 | HGNC ID: HGNC:4937 | Ensembl Gene: ENSG00000241106 | OMIM ID: 600629 |
| Drug and gene relationship at DGIdb | |||
HLA-DOB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis |
Expression of HLA-DOB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DOB | 3112 | 205671_s_at | 0.4059 | 0.7575 | |
| GSE20347 | HLA-DOB | 3112 | 205671_s_at | 0.4054 | 0.0360 | |
| GSE23400 | HLA-DOB | 3112 | 205671_s_at | 0.1021 | 0.1282 | |
| GSE26886 | HLA-DOB | 3112 | 205671_s_at | 0.2718 | 0.3670 | |
| GSE29001 | HLA-DOB | 3112 | 205671_s_at | 0.1764 | 0.5461 | |
| GSE38129 | HLA-DOB | 3112 | 205671_s_at | 0.1859 | 0.3965 | |
| GSE45670 | HLA-DOB | 3112 | 205671_s_at | 0.2513 | 0.3446 | |
| GSE53622 | HLA-DOB | 3112 | 19903 | 0.1748 | 0.3525 | |
| GSE53624 | HLA-DOB | 3112 | 19903 | -0.1461 | 0.3290 | |
| GSE63941 | HLA-DOB | 3112 | 205671_s_at | 0.4626 | 0.2227 | |
| GSE77861 | HLA-DOB | 3112 | 1554984_a_at | -0.1581 | 0.0811 | |
| GSE97050 | HLA-DOB | 3112 | A_23_P30736 | 0.8357 | 0.1581 | |
| SRP064894 | HLA-DOB | 3112 | RNAseq | 0.3531 | 0.2638 | |
| SRP133303 | HLA-DOB | 3112 | RNAseq | -0.3583 | 0.2480 | |
| SRP159526 | HLA-DOB | 3112 | RNAseq | -0.3259 | 0.7047 | |
| SRP193095 | HLA-DOB | 3112 | RNAseq | 0.3820 | 0.2110 | |
| SRP219564 | HLA-DOB | 3112 | RNAseq | 1.1140 | 0.0428 | |
| TCGA | HLA-DOB | 3112 | RNAseq | 0.3023 | 0.1861 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HLA-DOB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DOB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DOB | 3112 | 7 | 0 | 23 | |
| GSE20123 | HLA-DOB | 3112 | 7 | 0 | 23 | |
| GSE43470 | HLA-DOB | 3112 | 6 | 3 | 34 | |
| GSE46452 | HLA-DOB | 3112 | 2 | 10 | 47 | |
| GSE47630 | HLA-DOB | 3112 | 8 | 4 | 28 | |
| GSE54993 | HLA-DOB | 3112 | 3 | 1 | 66 | |
| GSE54994 | HLA-DOB | 3112 | 11 | 4 | 38 | |
| GSE60625 | HLA-DOB | 3112 | 1 | 0 | 10 | |
| GSE74703 | HLA-DOB | 3112 | 5 | 2 | 29 | |
| GSE74704 | HLA-DOB | 3112 | 3 | 0 | 17 |
Total number of gains: 53; Total number of losses: 24; Total Number of normals: 315.
Somatic mutations of HLA-DOB:
Generating mutation plots.
Highly correlated genes for HLA-DOB:
Showing top 20/267 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DOB | NDOR1 | 0.781846 | 3 | 0 | 3 |
| HLA-DOB | ZC3H12D | 0.724618 | 3 | 0 | 3 |
| HLA-DOB | FCRL5 | 0.719675 | 5 | 0 | 5 |
| HLA-DOB | MAPK11 | 0.698533 | 3 | 0 | 3 |
| HLA-DOB | SLC12A9 | 0.693864 | 3 | 0 | 3 |
| HLA-DOB | RCE1 | 0.686921 | 3 | 0 | 3 |
| HLA-DOB | JAK3 | 0.676933 | 6 | 0 | 6 |
| HLA-DOB | TNFSF8 | 0.676906 | 5 | 0 | 4 |
| HLA-DOB | IGLL1 | 0.673479 | 5 | 0 | 5 |
| HLA-DOB | KCNA3 | 0.670761 | 6 | 0 | 5 |
| HLA-DOB | PNOC | 0.66886 | 6 | 0 | 5 |
| HLA-DOB | GAPT | 0.666887 | 4 | 0 | 3 |
| HLA-DOB | MMP16 | 0.666671 | 3 | 0 | 3 |
| HLA-DOB | IKBKG | 0.666018 | 3 | 0 | 3 |
| HLA-DOB | IL32 | 0.660171 | 5 | 0 | 4 |
| HLA-DOB | IKZF3 | 0.657883 | 7 | 0 | 5 |
| HLA-DOB | HLA-DOA | 0.65758 | 7 | 0 | 6 |
| HLA-DOB | POU2AF1 | 0.656957 | 4 | 0 | 3 |
| HLA-DOB | HSH2D | 0.653874 | 4 | 0 | 3 |
| HLA-DOB | CKM | 0.653634 | 3 | 0 | 3 |
For details and further investigation, click here
