Full name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Alias Symbol: IKK-gamma|NEMO|Fip3p|FIP-3|FIP3|ZC2HC9
Type: protein-coding gene	Cytoband: Xq28
Entrez ID: 8517	HGNC ID: HGNC:5961	Ensembl Gene: ENSG00000269335	OMIM ID: 300248
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 30/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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IKBKG involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04014	Ras signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04064	NF-kappa B signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04210	Apoptosis	View
hsa04620	Toll-like receptor signaling pathway	View
hsa04621	NOD-like receptor signaling pathway	View
hsa04622	RIG-I-like receptor signaling pathway	View
hsa04623	Cytosolic DNA-sensing pathway	View
hsa04660	T cell receptor signaling pathway	View
hsa04662	B cell receptor signaling pathway	View
hsa04668	TNF signaling pathway	View
hsa04920	Adipocytokine signaling pathway	View
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	View
hsa05131	Shigellosis	View
hsa05142	Chagas disease (American trypanosomiasis)	View
hsa05145	Toxoplasmosis	View
hsa05160	Hepatitis C	View
hsa05161	Hepatitis B	View
hsa05166	HTLV-I infection	View
hsa05168	Herpes simplex infection	View
hsa05169	Epstein-Barr virus infection	View
hsa05200	Pathways in cancer	View
hsa05212	Pancreatic cancer	View
hsa05215	Prostate cancer	View
hsa05220	Chronic myeloid leukemia	View
hsa05221	Acute myeloid leukemia	View
hsa05222	Small cell lung cancer	View

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Expression of IKBKG:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	IKBKG	8517	209929_s_at	0.0113	0.9810	Show
GSE20347	IKBKG	8517	209929_s_at	0.4897	0.0309	Show
GSE23400	IKBKG	8517	36004_at	0.1525	0.0006	Show
GSE26886	IKBKG	8517	209929_s_at	0.6054	0.0033	Show
GSE29001	IKBKG	8517	209929_s_at	0.0329	0.9018	Show
GSE38129	IKBKG	8517	209929_s_at	0.4666	0.0063	Show
GSE45670	IKBKG	8517	209929_s_at	0.2933	0.0889	Show
GSE53622	IKBKG	8517	57800	0.4668	0.0000	Show
GSE53624	IKBKG	8517	80970	0.5752	0.0000	Show
GSE63941	IKBKG	8517	209929_s_at	-0.2990	0.3053	Show
GSE77861	IKBKG	8517	36004_at	0.2200	0.2136	Show
GSE97050	IKBKG	8517	A_23_P159920	0.5953	0.1214	Show
SRP007169	IKBKG	8517	RNAseq	0.3346	0.5159	Show
SRP008496	IKBKG	8517	RNAseq	0.4304	0.1342	Show
SRP064894	IKBKG	8517	RNAseq	0.5225	0.0028	Show
SRP133303	IKBKG	8517	RNAseq	0.6245	0.0024	Show
SRP159526	IKBKG	8517	RNAseq	0.1908	0.5286	Show
SRP193095	IKBKG	8517	RNAseq	0.6337	0.0001	Show
SRP219564	IKBKG	8517	RNAseq	0.2555	0.2648	Show
TCGA	IKBKG	8517	RNAseq	0.2029	0.0007	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by IKBKG expression:

 

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Copy number change of IKBKG:

 

No record found for this gene.

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Somatic mutations of IKBKG:

 

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Highly correlated genes for IKBKG:

 

Showing top 20/458 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
IKBKG	RHO	0.755244	3	0	3
IKBKG	POU3F4	0.721921	3	0	3
IKBKG	FAM111B	0.711378	3	0	3
IKBKG	CYSLTR2	0.700689	3	0	3
IKBKG	TGFB1	0.69985	3	0	3
IKBKG	NOVA2	0.697444	3	0	3
IKBKG	ZYX	0.684014	4	0	4
IKBKG	ZFHX4-AS1	0.68176	3	0	3
IKBKG	ARHGEF38	0.677425	3	0	3
IKBKG	SHKBP1	0.673447	5	0	5
IKBKG	CIB2	0.670117	3	0	3
IKBKG	HLA-DOB	0.666018	3	0	3
IKBKG	TRHR	0.662665	3	0	3
IKBKG	CD80	0.660261	3	0	3
IKBKG	TRPM6	0.660202	4	0	4
IKBKG	CDK2AP1	0.657089	3	0	3
IKBKG	TTLL10	0.654533	3	0	3
IKBKG	HTR1F	0.649646	3	0	3
IKBKG	NXPE3	0.648745	4	0	4
IKBKG	DENND3	0.648311	3	0	3

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