| Full name: hematopoietic SH2 domain containing | Alias Symbol: ALX|HSH2|FLJ14886 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 84941 | HGNC ID: HGNC:24920 | Ensembl Gene: ENSG00000196684 | OMIM ID: 608349 |
| Drug and gene relationship at DGIdb | |||
Expression of HSH2D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSH2D | 84941 | 1552623_at | 0.0092 | 0.9881 | |
| GSE26886 | HSH2D | 84941 | 1552623_at | -0.1408 | 0.2911 | |
| GSE45670 | HSH2D | 84941 | 1552623_at | 0.2803 | 0.1164 | |
| GSE53622 | HSH2D | 84941 | 117844 | -0.1102 | 0.1750 | |
| GSE53624 | HSH2D | 84941 | 117844 | -0.1056 | 0.1766 | |
| GSE63941 | HSH2D | 84941 | 1552623_at | 0.6237 | 0.2281 | |
| GSE77861 | HSH2D | 84941 | 1552623_at | -0.2434 | 0.0089 | |
| GSE97050 | HSH2D | 84941 | A_33_P3364289 | 0.4465 | 0.3240 | |
| SRP007169 | HSH2D | 84941 | RNAseq | 0.2009 | 0.7875 | |
| SRP064894 | HSH2D | 84941 | RNAseq | 0.4857 | 0.1917 | |
| SRP133303 | HSH2D | 84941 | RNAseq | 0.0093 | 0.9608 | |
| SRP159526 | HSH2D | 84941 | RNAseq | -0.8135 | 0.3297 | |
| SRP193095 | HSH2D | 84941 | RNAseq | 0.2261 | 0.4624 | |
| SRP219564 | HSH2D | 84941 | RNAseq | 0.8872 | 0.2381 | |
| TCGA | HSH2D | 84941 | RNAseq | -0.4050 | 0.0495 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HSH2D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSH2D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSH2D | 84941 | 4 | 3 | 23 | |
| GSE20123 | HSH2D | 84941 | 3 | 2 | 25 | |
| GSE43470 | HSH2D | 84941 | 2 | 6 | 35 | |
| GSE46452 | HSH2D | 84941 | 47 | 1 | 11 | |
| GSE47630 | HSH2D | 84941 | 4 | 8 | 28 | |
| GSE54993 | HSH2D | 84941 | 15 | 4 | 51 | |
| GSE54994 | HSH2D | 84941 | 6 | 14 | 33 | |
| GSE60625 | HSH2D | 84941 | 9 | 0 | 2 | |
| GSE74703 | HSH2D | 84941 | 2 | 4 | 30 | |
| GSE74704 | HSH2D | 84941 | 0 | 1 | 19 | |
| TCGA | HSH2D | 84941 | 17 | 11 | 68 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of HSH2D:
Generating mutation plots.
Highly correlated genes for HSH2D:
Showing top 20/106 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSH2D | IL10RA | 0.717735 | 4 | 0 | 4 |
| HSH2D | ZNF831 | 0.681198 | 3 | 0 | 3 |
| HSH2D | APOA2 | 0.678853 | 3 | 0 | 3 |
| HSH2D | SASH3 | 0.677161 | 4 | 0 | 4 |
| HSH2D | UNC13D | 0.674565 | 3 | 0 | 3 |
| HSH2D | RNASE6 | 0.669828 | 3 | 0 | 3 |
| HSH2D | NLRC3 | 0.668138 | 3 | 0 | 3 |
| HSH2D | FAM78A | 0.667587 | 4 | 0 | 3 |
| HSH2D | ABI3 | 0.661791 | 5 | 0 | 4 |
| HSH2D | NDOR1 | 0.659516 | 3 | 0 | 3 |
| HSH2D | GNA15 | 0.659056 | 3 | 0 | 3 |
| HSH2D | CEACAM21 | 0.659039 | 3 | 0 | 3 |
| HSH2D | B3GNT3 | 0.658005 | 3 | 0 | 3 |
| HSH2D | MACC1 | 0.657681 | 3 | 0 | 3 |
| HSH2D | MS4A6A | 0.654894 | 3 | 0 | 3 |
| HSH2D | HLA-DOB | 0.653874 | 4 | 0 | 3 |
| HSH2D | TRAF3IP3 | 0.648181 | 5 | 0 | 4 |
| HSH2D | TIGIT | 0.644934 | 3 | 0 | 3 |
| HSH2D | ARRDC1 | 0.642017 | 3 | 0 | 3 |
| HSH2D | MAP4K1 | 0.638448 | 5 | 0 | 4 |
For details and further investigation, click here
