| Full name: major histocompatibility complex, class II, DQ alpha 1 | Alias Symbol: CELIAC1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3117 | HGNC ID: HGNC:4942 | Ensembl Gene: ENSG00000196735 | OMIM ID: 146880 |
| Drug and gene relationship at DGIdb | |||
Expression of HLA-DQA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLA-DQA1 | 3117 | 213831_at | 0.3252 | 0.9399 | |
| GSE20347 | HLA-DQA1 | 3117 | 203290_at | -0.7313 | 0.2014 | |
| GSE23400 | HLA-DQA1 | 3117 | 203290_at | 0.3527 | 0.1866 | |
| GSE26886 | HLA-DQA1 | 3117 | 213831_at | -0.8013 | 0.4685 | |
| GSE29001 | HLA-DQA1 | 3117 | 203290_at | -0.2893 | 0.6402 | |
| GSE38129 | HLA-DQA1 | 3117 | 203290_at | -0.4846 | 0.3746 | |
| GSE45670 | HLA-DQA1 | 3117 | 203290_at | -0.6663 | 0.4156 | |
| GSE53622 | HLA-DQA1 | 3117 | 17534 | 0.1316 | 0.3907 | |
| GSE53624 | HLA-DQA1 | 3117 | 17534 | -0.1052 | 0.5255 | |
| GSE63941 | HLA-DQA1 | 3117 | 203290_at | 0.0870 | 0.4382 | |
| GSE77861 | HLA-DQA1 | 3117 | 213831_at | -0.3543 | 0.6046 | |
| GSE97050 | HLA-DQA1 | 3117 | A_33_P3273884 | 0.8650 | 0.2152 | |
| SRP007169 | HLA-DQA1 | 3117 | RNAseq | 0.5129 | 0.4331 | |
| SRP008496 | HLA-DQA1 | 3117 | RNAseq | 0.2058 | 0.6488 | |
| SRP064894 | HLA-DQA1 | 3117 | RNAseq | 0.2907 | 0.4052 | |
| SRP133303 | HLA-DQA1 | 3117 | RNAseq | -0.0841 | 0.7409 | |
| SRP159526 | HLA-DQA1 | 3117 | RNAseq | -0.1598 | 0.8641 | |
| SRP193095 | HLA-DQA1 | 3117 | RNAseq | -0.2457 | 0.3549 | |
| SRP219564 | HLA-DQA1 | 3117 | RNAseq | 1.6441 | 0.0019 | |
| TCGA | HLA-DQA1 | 3117 | RNAseq | 0.4156 | 0.0160 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HLA-DQA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DQA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DQA1 | 3117 | 7 | 0 | 23 | |
| GSE20123 | HLA-DQA1 | 3117 | 7 | 0 | 23 | |
| GSE43470 | HLA-DQA1 | 3117 | 7 | 2 | 34 | |
| GSE46452 | HLA-DQA1 | 3117 | 1 | 10 | 48 | |
| GSE47630 | HLA-DQA1 | 3117 | 7 | 5 | 28 | |
| GSE54993 | HLA-DQA1 | 3117 | 3 | 2 | 65 | |
| GSE54994 | HLA-DQA1 | 3117 | 11 | 4 | 38 | |
| GSE60625 | HLA-DQA1 | 3117 | 1 | 0 | 10 | |
| GSE74703 | HLA-DQA1 | 3117 | 6 | 1 | 29 | |
| GSE74704 | HLA-DQA1 | 3117 | 3 | 0 | 17 |
Total number of gains: 53; Total number of losses: 24; Total Number of normals: 315.
Somatic mutations of HLA-DQA1:
Generating mutation plots.
Highly correlated genes for HLA-DQA1:
Showing top 20/273 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DQA1 | HLA-DQA2 | 0.765558 | 3 | 0 | 3 |
| HLA-DQA1 | TNFSF8 | 0.74122 | 4 | 0 | 4 |
| HLA-DQA1 | HLA-DOA | 0.722075 | 6 | 0 | 5 |
| HLA-DQA1 | HLA-DMA | 0.707345 | 9 | 0 | 6 |
| HLA-DQA1 | TBXAS1 | 0.691437 | 4 | 0 | 4 |
| HLA-DQA1 | FPR3 | 0.687493 | 6 | 0 | 6 |
| HLA-DQA1 | HLA-DRA | 0.682577 | 11 | 0 | 7 |
| HLA-DQA1 | HLA-DQB1 | 0.678265 | 10 | 0 | 7 |
| HLA-DQA1 | HLA-DPB1 | 0.678227 | 10 | 0 | 6 |
| HLA-DQA1 | GNGT2 | 0.669735 | 4 | 0 | 4 |
| HLA-DQA1 | PARVG | 0.669234 | 6 | 0 | 5 |
| HLA-DQA1 | GPR171 | 0.661697 | 7 | 0 | 6 |
| HLA-DQA1 | CD84 | 0.656094 | 7 | 0 | 6 |
| HLA-DQA1 | ATP11C | 0.654692 | 3 | 0 | 3 |
| HLA-DQA1 | C1orf162 | 0.653659 | 7 | 0 | 5 |
| HLA-DQA1 | C1QC | 0.651405 | 7 | 0 | 5 |
| HLA-DQA1 | HLA-DMB | 0.650663 | 10 | 0 | 8 |
| HLA-DQA1 | SUSD3 | 0.649342 | 5 | 0 | 4 |
| HLA-DQA1 | CERKL | 0.647204 | 3 | 0 | 3 |
| HLA-DQA1 | CCL5 | 0.644994 | 5 | 0 | 4 |
For details and further investigation, click here
