| Full name: major histocompatibility complex, class II, DQ alpha 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 3118 | HGNC ID: HGNC:4943 | Ensembl Gene: ENSG00000237541 | OMIM ID: 613503 |
| Drug and gene relationship at DGIdb | |||
HLA-DQA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04612 | Antigen processing and presentation | |
| hsa05152 | Tuberculosis | |
| hsa05152 | Tuberculosis |
Expression of HLA-DQA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | HLA-DQA2 | 3118 | 2860 | -0.0773 | 0.7278 | |
| GSE53624 | HLA-DQA2 | 3118 | 2860 | -0.2396 | 0.1430 | |
| GSE97050 | HLA-DQA2 | 3118 | A_24_P852756 | 0.5154 | 0.3839 | |
| SRP007169 | HLA-DQA2 | 3118 | RNAseq | 0.1867 | 0.8341 | |
| SRP064894 | HLA-DQA2 | 3118 | RNAseq | 0.0232 | 0.9577 | |
| SRP133303 | HLA-DQA2 | 3118 | RNAseq | 0.0072 | 0.9865 | |
| SRP159526 | HLA-DQA2 | 3118 | RNAseq | -1.2209 | 0.2800 | |
| SRP219564 | HLA-DQA2 | 3118 | RNAseq | 0.8862 | 0.3722 | |
| TCGA | HLA-DQA2 | 3118 | RNAseq | 0.6160 | 0.0454 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HLA-DQA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLA-DQA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLA-DQA2 | 3118 | 7 | 0 | 23 | |
| GSE20123 | HLA-DQA2 | 3118 | 7 | 0 | 23 | |
| GSE43470 | HLA-DQA2 | 3118 | 7 | 2 | 34 | |
| GSE46452 | HLA-DQA2 | 3118 | 2 | 10 | 47 | |
| GSE47630 | HLA-DQA2 | 3118 | 7 | 5 | 28 | |
| GSE54993 | HLA-DQA2 | 3118 | 3 | 1 | 66 | |
| GSE54994 | HLA-DQA2 | 3118 | 11 | 4 | 38 | |
| GSE60625 | HLA-DQA2 | 3118 | 1 | 0 | 10 | |
| GSE74703 | HLA-DQA2 | 3118 | 6 | 1 | 29 | |
| GSE74704 | HLA-DQA2 | 3118 | 3 | 0 | 17 |
Total number of gains: 54; Total number of losses: 23; Total Number of normals: 315.
Somatic mutations of HLA-DQA2:
Generating mutation plots.
Highly correlated genes for HLA-DQA2:
Showing all 18 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLA-DQA2 | HLA-DQA1 | 0.765558 | 3 | 0 | 3 |
| HLA-DQA2 | HLA-DRA | 0.747739 | 3 | 0 | 3 |
| HLA-DQA2 | HLA-DMA | 0.729558 | 3 | 0 | 3 |
| HLA-DQA2 | HLA-DOA | 0.714621 | 3 | 0 | 3 |
| HLA-DQA2 | CD74 | 0.692748 | 3 | 0 | 3 |
| HLA-DQA2 | HLA-DMB | 0.660507 | 3 | 0 | 3 |
| HLA-DQA2 | HLA-DPA1 | 0.648404 | 3 | 0 | 3 |
| HLA-DQA2 | TLR7 | 0.6344 | 3 | 0 | 3 |
| HLA-DQA2 | MS4A6A | 0.633963 | 3 | 0 | 3 |
| HLA-DQA2 | IRF8 | 0.599299 | 3 | 0 | 3 |
| HLA-DQA2 | CSF1R | 0.599266 | 3 | 0 | 3 |
| HLA-DQA2 | CYBB | 0.59891 | 3 | 0 | 3 |
| HLA-DQA2 | AIF1 | 0.597745 | 3 | 0 | 3 |
| HLA-DQA2 | MS4A4A | 0.593422 | 3 | 0 | 3 |
| HLA-DQA2 | TMEM176B | 0.585602 | 3 | 0 | 3 |
| HLA-DQA2 | GRAP2 | 0.573294 | 3 | 0 | 3 |
| HLA-DQA2 | RGS1 | 0.564308 | 3 | 0 | 3 |
| HLA-DQA2 | C1QA | 0.549358 | 3 | 0 | 3 |
For details and further investigation, click here
