| Full name: high mobility group box 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q34.1 | ||
| Entrez ID: 3148 | HGNC ID: HGNC:5000 | Ensembl Gene: ENSG00000164104 | OMIM ID: 163906 |
Expression of HMGB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGB2 | 3148 | 208808_s_at | 0.2142 | 0.6911 | |
| GSE20347 | HMGB2 | 3148 | 208808_s_at | 0.7132 | 0.0002 | |
| GSE23400 | HMGB2 | 3148 | 208808_s_at | 1.0567 | 0.0000 | |
| GSE26886 | HMGB2 | 3148 | 208808_s_at | -0.3858 | 0.0830 | |
| GSE29001 | HMGB2 | 3148 | 208808_s_at | 0.5323 | 0.0081 | |
| GSE38129 | HMGB2 | 3148 | 208808_s_at | 0.7868 | 0.0000 | |
| GSE45670 | HMGB2 | 3148 | 208808_s_at | 0.1034 | 0.6686 | |
| GSE53622 | HMGB2 | 3148 | 11203 | 0.4989 | 0.0000 | |
| GSE53624 | HMGB2 | 3148 | 11203 | 0.7022 | 0.0000 | |
| GSE63941 | HMGB2 | 3148 | 208808_s_at | 1.9866 | 0.0005 | |
| GSE77861 | HMGB2 | 3148 | 208808_s_at | 0.2833 | 0.2602 | |
| GSE97050 | HMGB2 | 3148 | A_23_P155765 | 0.3266 | 0.4116 | |
| SRP007169 | HMGB2 | 3148 | RNAseq | 0.3661 | 0.3313 | |
| SRP008496 | HMGB2 | 3148 | RNAseq | 0.2649 | 0.2938 | |
| SRP064894 | HMGB2 | 3148 | RNAseq | 0.5692 | 0.0110 | |
| SRP133303 | HMGB2 | 3148 | RNAseq | 0.7661 | 0.0003 | |
| SRP159526 | HMGB2 | 3148 | RNAseq | 0.6888 | 0.1410 | |
| SRP193095 | HMGB2 | 3148 | RNAseq | 0.1430 | 0.4166 | |
| SRP219564 | HMGB2 | 3148 | RNAseq | 0.1282 | 0.6217 | |
| TCGA | HMGB2 | 3148 | RNAseq | 0.4340 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HMGB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGB2 | 3148 | 2 | 10 | 18 | |
| GSE20123 | HMGB2 | 3148 | 2 | 10 | 18 | |
| GSE43470 | HMGB2 | 3148 | 0 | 13 | 30 | |
| GSE46452 | HMGB2 | 3148 | 1 | 36 | 22 | |
| GSE47630 | HMGB2 | 3148 | 0 | 22 | 18 | |
| GSE54993 | HMGB2 | 3148 | 10 | 0 | 60 | |
| GSE54994 | HMGB2 | 3148 | 2 | 12 | 39 | |
| GSE60625 | HMGB2 | 3148 | 0 | 0 | 11 | |
| GSE74703 | HMGB2 | 3148 | 0 | 11 | 25 | |
| GSE74704 | HMGB2 | 3148 | 1 | 5 | 14 | |
| TCGA | HMGB2 | 3148 | 10 | 36 | 50 |
Total number of gains: 28; Total number of losses: 155; Total Number of normals: 305.
Somatic mutations of HMGB2:
Generating mutation plots.
Highly correlated genes for HMGB2:
Showing top 20/864 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGB2 | INTS12 | 0.77431 | 3 | 0 | 3 |
| HMGB2 | RPP38 | 0.772669 | 3 | 0 | 3 |
| HMGB2 | ZNF691 | 0.761863 | 3 | 0 | 3 |
| HMGB2 | ARHGAP9 | 0.747293 | 3 | 0 | 3 |
| HMGB2 | TRIM47 | 0.729547 | 3 | 0 | 3 |
| HMGB2 | DNAJC9 | 0.714859 | 8 | 0 | 8 |
| HMGB2 | HJURP | 0.713527 | 9 | 0 | 9 |
| HMGB2 | CENPH | 0.710911 | 4 | 0 | 4 |
| HMGB2 | MMS22L | 0.710359 | 3 | 0 | 3 |
| HMGB2 | UCK2 | 0.70743 | 3 | 0 | 3 |
| HMGB2 | SMCR8 | 0.70481 | 3 | 0 | 3 |
| HMGB2 | RAD51AP1 | 0.704275 | 9 | 0 | 9 |
| HMGB2 | CMTM4 | 0.702695 | 3 | 0 | 3 |
| HMGB2 | MSH6 | 0.695528 | 10 | 0 | 8 |
| HMGB2 | C1orf112 | 0.694869 | 8 | 0 | 7 |
| HMGB2 | MCM6 | 0.693197 | 10 | 0 | 9 |
| HMGB2 | ARL6IP6 | 0.69258 | 5 | 0 | 4 |
| HMGB2 | MND1 | 0.689532 | 7 | 0 | 6 |
| HMGB2 | CDK1 | 0.689455 | 9 | 0 | 8 |
| HMGB2 | FOXM1 | 0.688667 | 8 | 0 | 8 |
For details and further investigation, click here
