| Full name: actin related protein 2/3 complex subunit 3 | Alias Symbol: p21-Arc|ARC21 | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 10094 | HGNC ID: HGNC:706 | Ensembl Gene: ENSG00000111229 | OMIM ID: 604225 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ARPC3 involved pathways:
Expression of ARPC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARPC3 | 10094 | 208736_at | -0.1031 | 0.8800 | |
| GSE20347 | ARPC3 | 10094 | 208736_at | -0.7123 | 0.0000 | |
| GSE23400 | ARPC3 | 10094 | 208736_at | -0.3765 | 0.0006 | |
| GSE26886 | ARPC3 | 10094 | 208736_at | -0.6702 | 0.0025 | |
| GSE29001 | ARPC3 | 10094 | 208736_at | -0.7890 | 0.1001 | |
| GSE38129 | ARPC3 | 10094 | 208736_at | -0.3224 | 0.0413 | |
| GSE45670 | ARPC3 | 10094 | 208736_at | -0.1250 | 0.3808 | |
| GSE53622 | ARPC3 | 10094 | 5528 | -0.4393 | 0.0000 | |
| GSE53624 | ARPC3 | 10094 | 5528 | -0.4744 | 0.0000 | |
| GSE63941 | ARPC3 | 10094 | 208736_at | 1.5734 | 0.0001 | |
| GSE77861 | ARPC3 | 10094 | 208736_at | -0.6264 | 0.0067 | |
| GSE97050 | ARPC3 | 10094 | A_24_P167473 | 0.1036 | 0.7966 | |
| SRP007169 | ARPC3 | 10094 | RNAseq | -1.5571 | 0.0000 | |
| SRP008496 | ARPC3 | 10094 | RNAseq | -1.5233 | 0.0000 | |
| SRP064894 | ARPC3 | 10094 | RNAseq | -0.4891 | 0.0066 | |
| SRP133303 | ARPC3 | 10094 | RNAseq | -0.2366 | 0.0761 | |
| SRP159526 | ARPC3 | 10094 | RNAseq | -0.6867 | 0.0245 | |
| SRP193095 | ARPC3 | 10094 | RNAseq | -0.9128 | 0.0000 | |
| SRP219564 | ARPC3 | 10094 | RNAseq | -0.7459 | 0.0436 | |
| TCGA | ARPC3 | 10094 | RNAseq | 0.1602 | 0.0012 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ARPC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARPC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARPC3 | 10094 | 5 | 3 | 22 | |
| GSE20123 | ARPC3 | 10094 | 5 | 3 | 22 | |
| GSE43470 | ARPC3 | 10094 | 2 | 1 | 40 | |
| GSE46452 | ARPC3 | 10094 | 9 | 1 | 49 | |
| GSE47630 | ARPC3 | 10094 | 9 | 3 | 28 | |
| GSE54993 | ARPC3 | 10094 | 0 | 5 | 65 | |
| GSE54994 | ARPC3 | 10094 | 4 | 3 | 46 | |
| GSE60625 | ARPC3 | 10094 | 0 | 0 | 11 | |
| GSE74703 | ARPC3 | 10094 | 2 | 0 | 34 | |
| GSE74704 | ARPC3 | 10094 | 2 | 2 | 16 | |
| TCGA | ARPC3 | 10094 | 22 | 10 | 64 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of ARPC3:
Generating mutation plots.
Highly correlated genes for ARPC3:
Showing top 20/1377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARPC3 | IRX3 | 0.772053 | 4 | 0 | 4 |
| ARPC3 | RASSF5 | 0.750372 | 7 | 0 | 7 |
| ARPC3 | EBPL | 0.749889 | 4 | 0 | 4 |
| ARPC3 | TYSND1 | 0.745727 | 4 | 0 | 4 |
| ARPC3 | SPIN4 | 0.741626 | 3 | 0 | 3 |
| ARPC3 | RPL19 | 0.740556 | 3 | 0 | 3 |
| ARPC3 | VAMP8 | 0.73867 | 12 | 0 | 11 |
| ARPC3 | MITD1 | 0.734148 | 3 | 0 | 3 |
| ARPC3 | NUAK2 | 0.733107 | 3 | 0 | 3 |
| ARPC3 | VPS25 | 0.727235 | 7 | 0 | 7 |
| ARPC3 | TP53RK | 0.726959 | 3 | 0 | 3 |
| ARPC3 | MPZL2 | 0.724757 | 12 | 0 | 12 |
| ARPC3 | ARHGAP27 | 0.723334 | 8 | 0 | 8 |
| ARPC3 | IL10RB | 0.721297 | 10 | 0 | 10 |
| ARPC3 | RAB25 | 0.717991 | 13 | 0 | 11 |
| ARPC3 | DHCR24 | 0.713035 | 11 | 0 | 11 |
| ARPC3 | TAB3 | 0.712375 | 7 | 0 | 7 |
| ARPC3 | ARPC1A | 0.712164 | 4 | 0 | 4 |
| ARPC3 | TSPO | 0.710411 | 11 | 0 | 10 |
| ARPC3 | MARVELD2 | 0.70883 | 5 | 0 | 4 |
For details and further investigation, click here
