| Full name: collagen type III alpha 1 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 1281 | HGNC ID: HGNC:2201 | Ensembl Gene: ENSG00000168542 | OMIM ID: 120180 |
| Drug and gene relationship at DGIdb | |||
COL3A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04611 | Platelet activation |
Expression of COL3A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL3A1 | 1281 | 215076_s_at | 1.2845 | 0.2486 | |
| GSE20347 | COL3A1 | 1281 | 215076_s_at | 2.2625 | 0.0001 | |
| GSE23400 | COL3A1 | 1281 | 201852_x_at | 2.2537 | 0.0000 | |
| GSE26886 | COL3A1 | 1281 | 215076_s_at | 2.6225 | 0.0000 | |
| GSE29001 | COL3A1 | 1281 | 215076_s_at | 1.8132 | 0.0056 | |
| GSE38129 | COL3A1 | 1281 | 215076_s_at | 2.2116 | 0.0000 | |
| GSE45670 | COL3A1 | 1281 | 215076_s_at | 0.7350 | 0.2398 | |
| GSE53622 | COL3A1 | 1281 | 49428 | 3.1596 | 0.0000 | |
| GSE53624 | COL3A1 | 1281 | 49428 | 3.1255 | 0.0000 | |
| GSE63941 | COL3A1 | 1281 | 215076_s_at | -9.5924 | 0.0000 | |
| GSE77861 | COL3A1 | 1281 | 215076_s_at | 2.5116 | 0.0083 | |
| GSE97050 | COL3A1 | 1281 | A_24_P935491 | 3.3214 | 0.0530 | |
| SRP007169 | COL3A1 | 1281 | RNAseq | 6.5323 | 0.0000 | |
| SRP008496 | COL3A1 | 1281 | RNAseq | 6.4656 | 0.0000 | |
| SRP064894 | COL3A1 | 1281 | RNAseq | 3.4685 | 0.0000 | |
| SRP133303 | COL3A1 | 1281 | RNAseq | 3.5495 | 0.0000 | |
| SRP159526 | COL3A1 | 1281 | RNAseq | 1.8985 | 0.0000 | |
| SRP193095 | COL3A1 | 1281 | RNAseq | 3.8699 | 0.0000 | |
| SRP219564 | COL3A1 | 1281 | RNAseq | 2.8096 | 0.0013 | |
| TCGA | COL3A1 | 1281 | RNAseq | 0.3558 | 0.0004 |
Upregulated datasets: 15; Downregulated datasets: 1.
Survival by COL3A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL3A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL3A1 | 1281 | 9 | 2 | 19 | |
| GSE20123 | COL3A1 | 1281 | 9 | 2 | 19 | |
| GSE43470 | COL3A1 | 1281 | 3 | 1 | 39 | |
| GSE46452 | COL3A1 | 1281 | 1 | 4 | 54 | |
| GSE47630 | COL3A1 | 1281 | 4 | 5 | 31 | |
| GSE54993 | COL3A1 | 1281 | 0 | 5 | 65 | |
| GSE54994 | COL3A1 | 1281 | 12 | 6 | 35 | |
| GSE60625 | COL3A1 | 1281 | 0 | 3 | 8 | |
| GSE74703 | COL3A1 | 1281 | 2 | 1 | 33 | |
| GSE74704 | COL3A1 | 1281 | 3 | 2 | 15 | |
| TCGA | COL3A1 | 1281 | 23 | 7 | 66 |
Total number of gains: 66; Total number of losses: 38; Total Number of normals: 384.
Somatic mutations of COL3A1:
Generating mutation plots.
Highly correlated genes for COL3A1:
Showing top 20/1074 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL3A1 | COL6A3 | 0.93894 | 13 | 0 | 13 |
| COL3A1 | COL1A1 | 0.933579 | 12 | 0 | 12 |
| COL3A1 | COL1A2 | 0.922398 | 13 | 0 | 13 |
| COL3A1 | POSTN | 0.902844 | 13 | 0 | 13 |
| COL3A1 | COL5A2 | 0.895283 | 13 | 0 | 13 |
| COL3A1 | SPARC | 0.891491 | 13 | 0 | 12 |
| COL3A1 | VCAN | 0.886079 | 13 | 0 | 13 |
| COL3A1 | COL5A1 | 0.84663 | 13 | 0 | 13 |
| COL3A1 | CTHRC1 | 0.841711 | 9 | 0 | 9 |
| COL3A1 | LUM | 0.837484 | 13 | 0 | 13 |
| COL3A1 | FN1 | 0.834888 | 12 | 0 | 12 |
| COL3A1 | THY1 | 0.827082 | 13 | 0 | 13 |
| COL3A1 | THBS2 | 0.826562 | 13 | 0 | 13 |
| COL3A1 | CTSK | 0.826271 | 13 | 0 | 13 |
| COL3A1 | SULF1 | 0.822278 | 13 | 0 | 13 |
| COL3A1 | CDH11 | 0.820379 | 13 | 0 | 13 |
| COL3A1 | FAP | 0.810945 | 11 | 0 | 11 |
| COL3A1 | NID2 | 0.796995 | 10 | 0 | 10 |
| COL3A1 | FBN1 | 0.789644 | 10 | 0 | 10 |
| COL3A1 | COL12A1 | 0.785639 | 9 | 0 | 8 |
For details and further investigation, click here
