| Full name: hydroxysteroid 11-beta dehydrogenase 2 | Alias Symbol: SDR9C3 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 3291 | HGNC ID: HGNC:5209 | Ensembl Gene: ENSG00000176387 | OMIM ID: 614232 |
| Related drugs: HYDROCORTISONE... [more] | |||
Expression of HSD11B2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSD11B2 | 3291 | 204130_at | 0.0082 | 0.9799 | |
| GSE20347 | HSD11B2 | 3291 | 204130_at | 0.3005 | 0.1527 | |
| GSE23400 | HSD11B2 | 3291 | 204130_at | -0.0273 | 0.6501 | |
| GSE26886 | HSD11B2 | 3291 | 204130_at | 0.7419 | 0.0059 | |
| GSE29001 | HSD11B2 | 3291 | 204130_at | -0.0797 | 0.7901 | |
| GSE38129 | HSD11B2 | 3291 | 204130_at | 0.4498 | 0.0102 | |
| GSE45670 | HSD11B2 | 3291 | 204130_at | 0.1281 | 0.6666 | |
| GSE53622 | HSD11B2 | 3291 | 40688 | -0.0550 | 0.7789 | |
| GSE53624 | HSD11B2 | 3291 | 40688 | 0.0447 | 0.7373 | |
| GSE63941 | HSD11B2 | 3291 | 204130_at | 1.0386 | 0.0187 | |
| GSE77861 | HSD11B2 | 3291 | 204130_at | 0.2814 | 0.1617 | |
| GSE97050 | HSD11B2 | 3291 | A_23_P14986 | 0.0500 | 0.8804 | |
| SRP007169 | HSD11B2 | 3291 | RNAseq | 0.2514 | 0.6621 | |
| SRP064894 | HSD11B2 | 3291 | RNAseq | -0.0763 | 0.8290 | |
| SRP133303 | HSD11B2 | 3291 | RNAseq | -0.0696 | 0.8078 | |
| SRP159526 | HSD11B2 | 3291 | RNAseq | 0.4785 | 0.3074 | |
| SRP193095 | HSD11B2 | 3291 | RNAseq | -0.2043 | 0.4949 | |
| SRP219564 | HSD11B2 | 3291 | RNAseq | -0.3399 | 0.6581 | |
| TCGA | HSD11B2 | 3291 | RNAseq | -0.1534 | 0.1922 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by HSD11B2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSD11B2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSD11B2 | 3291 | 9 | 2 | 19 | |
| GSE20123 | HSD11B2 | 3291 | 9 | 2 | 19 | |
| GSE43470 | HSD11B2 | 3291 | 1 | 9 | 33 | |
| GSE46452 | HSD11B2 | 3291 | 38 | 1 | 20 | |
| GSE47630 | HSD11B2 | 3291 | 10 | 8 | 22 | |
| GSE54993 | HSD11B2 | 3291 | 2 | 4 | 64 | |
| GSE54994 | HSD11B2 | 3291 | 8 | 10 | 35 | |
| GSE60625 | HSD11B2 | 3291 | 4 | 0 | 7 | |
| GSE74703 | HSD11B2 | 3291 | 1 | 6 | 29 | |
| GSE74704 | HSD11B2 | 3291 | 5 | 1 | 14 | |
| TCGA | HSD11B2 | 3291 | 29 | 12 | 55 |
Total number of gains: 116; Total number of losses: 55; Total Number of normals: 317.
Somatic mutations of HSD11B2:
Generating mutation plots.
Highly correlated genes for HSD11B2:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSD11B2 | RBM19 | 0.640561 | 3 | 0 | 3 |
| HSD11B2 | WDR53 | 0.636266 | 3 | 0 | 3 |
| HSD11B2 | ACTR3B | 0.631424 | 4 | 0 | 3 |
| HSD11B2 | FOXJ1 | 0.629819 | 4 | 0 | 4 |
| HSD11B2 | ZFPM1 | 0.626315 | 4 | 0 | 4 |
| HSD11B2 | PGP | 0.616097 | 5 | 0 | 4 |
| HSD11B2 | KAT2A | 0.610171 | 3 | 0 | 3 |
| HSD11B2 | PODXL2 | 0.608867 | 4 | 0 | 3 |
| HSD11B2 | HIRIP3 | 0.603266 | 3 | 0 | 3 |
| HSD11B2 | MYBPH | 0.602956 | 3 | 0 | 3 |
| HSD11B2 | CNIH2 | 0.601704 | 3 | 0 | 3 |
| HSD11B2 | PCSK9 | 0.600185 | 4 | 0 | 3 |
| HSD11B2 | SLC4A11 | 0.59255 | 4 | 0 | 3 |
| HSD11B2 | MUC5AC | 0.590601 | 3 | 0 | 3 |
| HSD11B2 | SP8 | 0.58662 | 3 | 0 | 3 |
| HSD11B2 | ARVCF | 0.586499 | 4 | 0 | 3 |
| HSD11B2 | BEND3 | 0.585784 | 4 | 0 | 3 |
| HSD11B2 | SBK1 | 0.578043 | 3 | 0 | 3 |
| HSD11B2 | KLRG2 | 0.574323 | 4 | 0 | 3 |
| HSD11B2 | NOB1 | 0.573726 | 3 | 0 | 3 |
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