| Full name: WD repeat domain 53 | Alias Symbol: MGC64882|MGC12928 | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 348793 | HGNC ID: HGNC:28786 | Ensembl Gene: ENSG00000185798 | OMIM ID: 615110 |
| Drug and gene relationship at DGIdb | |||
Expression of WDR53:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR53 | 348793 | 227814_at | 0.9560 | 0.0248 | |
| GSE26886 | WDR53 | 348793 | 227814_at | 0.4576 | 0.0007 | |
| GSE45670 | WDR53 | 348793 | 227814_at | 0.8270 | 0.0001 | |
| GSE53622 | WDR53 | 348793 | 146928 | 0.9566 | 0.0000 | |
| GSE53624 | WDR53 | 348793 | 146928 | 1.1821 | 0.0000 | |
| GSE63941 | WDR53 | 348793 | 227814_at | 1.1159 | 0.0148 | |
| GSE77861 | WDR53 | 348793 | 227814_at | 0.4251 | 0.0176 | |
| GSE97050 | WDR53 | 348793 | A_23_P110076 | 0.5531 | 0.2144 | |
| SRP007169 | WDR53 | 348793 | RNAseq | 0.4916 | 0.2917 | |
| SRP008496 | WDR53 | 348793 | RNAseq | 1.1288 | 0.0006 | |
| SRP064894 | WDR53 | 348793 | RNAseq | 1.1394 | 0.0000 | |
| SRP133303 | WDR53 | 348793 | RNAseq | 1.0248 | 0.0000 | |
| SRP159526 | WDR53 | 348793 | RNAseq | 1.3208 | 0.0000 | |
| SRP193095 | WDR53 | 348793 | RNAseq | 0.8797 | 0.0000 | |
| SRP219564 | WDR53 | 348793 | RNAseq | 0.5751 | 0.2172 | |
| TCGA | WDR53 | 348793 | RNAseq | 0.5849 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by WDR53 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR53:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR53 | 348793 | 22 | 0 | 8 | |
| GSE20123 | WDR53 | 348793 | 22 | 0 | 8 | |
| GSE43470 | WDR53 | 348793 | 21 | 0 | 22 | |
| GSE46452 | WDR53 | 348793 | 19 | 1 | 39 | |
| GSE47630 | WDR53 | 348793 | 27 | 2 | 11 | |
| GSE54993 | WDR53 | 348793 | 1 | 22 | 47 | |
| GSE54994 | WDR53 | 348793 | 41 | 0 | 12 | |
| GSE60625 | WDR53 | 348793 | 0 | 6 | 5 | |
| GSE74703 | WDR53 | 348793 | 19 | 0 | 17 | |
| GSE74704 | WDR53 | 348793 | 14 | 0 | 6 | |
| TCGA | WDR53 | 348793 | 76 | 0 | 20 |
Total number of gains: 262; Total number of losses: 31; Total Number of normals: 195.
Somatic mutations of WDR53:
Generating mutation plots.
Highly correlated genes for WDR53:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR53 | RFT1 | 0.756436 | 3 | 0 | 3 |
| WDR53 | FBXO45 | 0.749032 | 5 | 0 | 5 |
| WDR53 | HOXD10 | 0.73361 | 8 | 0 | 8 |
| WDR53 | TMEM248 | 0.73348 | 3 | 0 | 3 |
| WDR53 | MRGBP | 0.732497 | 6 | 0 | 6 |
| WDR53 | ACTL6A | 0.730014 | 8 | 0 | 8 |
| WDR53 | MRPS17 | 0.728238 | 5 | 0 | 4 |
| WDR53 | ATP13A3 | 0.724638 | 6 | 0 | 5 |
| WDR53 | CBX3 | 0.722362 | 7 | 0 | 6 |
| WDR53 | PLAU | 0.717831 | 6 | 0 | 6 |
| WDR53 | TREM2 | 0.714485 | 4 | 0 | 4 |
| WDR53 | ZNF593 | 0.714181 | 4 | 0 | 4 |
| WDR53 | CDC25B | 0.71378 | 5 | 0 | 5 |
| WDR53 | CEP72 | 0.712756 | 5 | 0 | 5 |
| WDR53 | CDC20 | 0.710013 | 7 | 0 | 6 |
| WDR53 | IGF2BP2 | 0.708855 | 6 | 0 | 5 |
| WDR53 | TENM2 | 0.708145 | 4 | 0 | 4 |
| WDR53 | ATP1B3 | 0.707471 | 6 | 0 | 5 |
| WDR53 | CMSS1 | 0.706927 | 7 | 0 | 6 |
| WDR53 | ANLN | 0.702453 | 5 | 0 | 4 |
For details and further investigation, click here
