| Full name: gamma-aminobutyric acid type A receptor beta1 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p12 | ||
| Entrez ID: 2560 | HGNC ID: HGNC:4081 | Ensembl Gene: ENSG00000163288 | OMIM ID: 137190 |
| Drug and gene relationship at DGIdb | |||
GABRB1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRB1 | 2560 | 207010_at | 0.0356 | 0.8977 | |
| GSE20347 | GABRB1 | 2560 | 207010_at | -0.0220 | 0.8071 | |
| GSE23400 | GABRB1 | 2560 | 207010_at | -0.0561 | 0.0460 | |
| GSE26886 | GABRB1 | 2560 | 207010_at | -0.1335 | 0.1995 | |
| GSE29001 | GABRB1 | 2560 | 207010_at | 0.0740 | 0.8219 | |
| GSE38129 | GABRB1 | 2560 | 207010_at | -0.0755 | 0.6454 | |
| GSE45670 | GABRB1 | 2560 | 207010_at | 0.1452 | 0.2757 | |
| GSE53622 | GABRB1 | 2560 | 122257 | -0.0015 | 0.9936 | |
| GSE53624 | GABRB1 | 2560 | 122257 | 0.0111 | 0.9270 | |
| GSE63941 | GABRB1 | 2560 | 207010_at | 0.0016 | 0.9983 | |
| GSE77861 | GABRB1 | 2560 | 207010_at | 0.0467 | 0.7824 | |
| GSE97050 | GABRB1 | 2560 | A_33_P3312544 | -0.1010 | 0.7212 | |
| TCGA | GABRB1 | 2560 | RNAseq | -0.5284 | 0.6179 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GABRB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRB1 | 2560 | 1 | 15 | 14 | |
| GSE20123 | GABRB1 | 2560 | 1 | 15 | 14 | |
| GSE43470 | GABRB1 | 2560 | 0 | 14 | 29 | |
| GSE46452 | GABRB1 | 2560 | 1 | 37 | 21 | |
| GSE47630 | GABRB1 | 2560 | 1 | 18 | 21 | |
| GSE54993 | GABRB1 | 2560 | 7 | 0 | 63 | |
| GSE54994 | GABRB1 | 2560 | 4 | 9 | 40 | |
| GSE60625 | GABRB1 | 2560 | 0 | 0 | 11 | |
| GSE74703 | GABRB1 | 2560 | 0 | 12 | 24 | |
| GSE74704 | GABRB1 | 2560 | 0 | 9 | 11 | |
| TCGA | GABRB1 | 2560 | 16 | 33 | 47 |
Total number of gains: 31; Total number of losses: 162; Total Number of normals: 295.
Somatic mutations of GABRB1:
Generating mutation plots.
Highly correlated genes for GABRB1:
Showing top 20/186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRB1 | TMEM120B | 0.778627 | 3 | 0 | 3 |
| GABRB1 | RNF123 | 0.744611 | 3 | 0 | 3 |
| GABRB1 | C7orf61 | 0.739223 | 3 | 0 | 3 |
| GABRB1 | QPRT | 0.729433 | 3 | 0 | 3 |
| GABRB1 | MYOZ3 | 0.72541 | 4 | 0 | 4 |
| GABRB1 | CRABP1 | 0.719718 | 4 | 0 | 3 |
| GABRB1 | HSD17B3 | 0.719447 | 3 | 0 | 3 |
| GABRB1 | CA6 | 0.718728 | 3 | 0 | 3 |
| GABRB1 | ZNF692 | 0.714752 | 3 | 0 | 3 |
| GABRB1 | KIF1A | 0.714097 | 5 | 0 | 5 |
| GABRB1 | ACR | 0.704419 | 3 | 0 | 3 |
| GABRB1 | SLC5A4 | 0.703458 | 4 | 0 | 3 |
| GABRB1 | FCN2 | 0.699205 | 3 | 0 | 3 |
| GABRB1 | GH1 | 0.696101 | 3 | 0 | 3 |
| GABRB1 | ANKLE1 | 0.695563 | 3 | 0 | 3 |
| GABRB1 | TNFSF11 | 0.692032 | 3 | 0 | 3 |
| GABRB1 | GFRA4 | 0.691231 | 4 | 0 | 4 |
| GABRB1 | ATP2B2 | 0.687259 | 5 | 0 | 4 |
| GABRB1 | TPH1 | 0.686399 | 4 | 0 | 4 |
| GABRB1 | FZD9 | 0.686394 | 3 | 0 | 3 |
For details and further investigation, click here
