GTPBP4

 

Full name: GTP binding protein 4 Alias Symbol: CRFG|NGB|FLJ10690|FLJ10686|NOG1
Type: protein-coding gene Cytoband: 10p15.3
Entrez ID: 23560 HGNC ID: HGNC:21535 Ensembl Gene: ENSG00000107937 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GTPBP4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GTPBP4 23560 218239_s_at 0.7037 0.1120
GSE20347 GTPBP4 23560 218239_s_at 0.7510 0.0000
GSE23400 GTPBP4 23560 218239_s_at 0.5699 0.0000
GSE26886 GTPBP4 23560 218239_s_at 0.4598 0.0599
GSE29001 GTPBP4 23560 218239_s_at 0.7332 0.0029
GSE38129 GTPBP4 23560 218239_s_at 0.8293 0.0000
GSE45670 GTPBP4 23560 218239_s_at 0.5909 0.0041
GSE53622 GTPBP4 23560 76470 0.2943 0.0004
GSE53624 GTPBP4 23560 76470 0.5765 0.0000
GSE63941 GTPBP4 23560 218239_s_at 0.2273 0.6265
GSE77861 GTPBP4 23560 218239_s_at 0.4305 0.0515
GSE97050 GTPBP4 23560 A_23_P12874 0.6544 0.2085
SRP007169 GTPBP4 23560 RNAseq 1.2812 0.0019
SRP008496 GTPBP4 23560 RNAseq 1.5996 0.0000
SRP064894 GTPBP4 23560 RNAseq 0.3251 0.0578
SRP133303 GTPBP4 23560 RNAseq 0.4700 0.0012
SRP159526 GTPBP4 23560 RNAseq 0.2763 0.5346
SRP193095 GTPBP4 23560 RNAseq 0.4671 0.0001
SRP219564 GTPBP4 23560 RNAseq 0.2969 0.3254
TCGA GTPBP4 23560 RNAseq 0.1835 0.0011

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by GTPBP4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GTPBP4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GTPBP4 23560 5 10 15
GSE20123 GTPBP4 23560 5 10 15
GSE43470 GTPBP4 23560 3 8 32
GSE46452 GTPBP4 23560 2 14 43
GSE47630 GTPBP4 23560 5 15 20
GSE54993 GTPBP4 23560 11 0 59
GSE54994 GTPBP4 23560 4 10 39
GSE60625 GTPBP4 23560 0 0 11
GSE74703 GTPBP4 23560 2 5 29
GSE74704 GTPBP4 23560 1 9 10
TCGA GTPBP4 23560 17 28 51

Total number of gains: 55; Total number of losses: 109; Total Number of normals: 324.  

 

Somatic mutations of GTPBP4:

 

Generating mutation plots.

 

Highly correlated genes for GTPBP4:

 

Showing top 20/1530 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GTPBP4CDCA20.747388404
GTPBP4TMEM167A0.721396303
GTPBP4LY6K0.714511303
GTPBP4FIGNL10.708529403
GTPBP4HSD17B60.708282303
GTPBP4BMS10.701839807
GTPBP4NEK20.693428909
GTPBP4ALS20.690051404
GTPBP4HEATR10.6896021109
GTPBP4BUB1B0.68875707
GTPBP4G2E30.6879404
GTPBP4DSCC10.686767909
GTPBP4STAMBPL10.685874303
GTPBP4MCM100.68583811010
GTPBP4SFR10.684491403
GTPBP4DUS3L0.684296303
GTPBP4RSPRY10.684043303
GTPBP4NUP1070.68175412011
GTPBP4BUB10.681057806
GTPBP4ATP11A0.680131303

For details and further investigation, click here