| Full name: KIT ligand | Alias Symbol: SCF|SF|Kitl|KL-1|FPH2|SLF|DFNA69 | ||
| Type: protein-coding gene | Cytoband: 12q21.32 | ||
| Entrez ID: 4254 | HGNC ID: HGNC:6343 | Ensembl Gene: ENSG00000049130 | OMIM ID: 184745 |
| Drug and gene relationship at DGIdb | |||
KITLG involved pathways:
Expression of KITLG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KITLG | 4254 | 226534_at | -1.0304 | 0.2363 | |
| GSE20347 | KITLG | 4254 | 207029_at | 0.0001 | 0.9989 | |
| GSE23400 | KITLG | 4254 | 207029_at | 0.0615 | 0.1799 | |
| GSE26886 | KITLG | 4254 | 226534_at | 1.2873 | 0.0009 | |
| GSE29001 | KITLG | 4254 | 211124_s_at | -0.0207 | 0.8811 | |
| GSE38129 | KITLG | 4254 | 207029_at | 0.0596 | 0.3232 | |
| GSE45670 | KITLG | 4254 | 226534_at | -0.6539 | 0.0287 | |
| GSE63941 | KITLG | 4254 | 226534_at | -2.3547 | 0.0307 | |
| GSE77861 | KITLG | 4254 | 226534_at | 0.1657 | 0.7733 | |
| GSE97050 | KITLG | 4254 | A_24_P133253 | -0.8914 | 0.1714 | |
| SRP007169 | KITLG | 4254 | RNAseq | -0.2563 | 0.5340 | |
| SRP008496 | KITLG | 4254 | RNAseq | 0.8197 | 0.0683 | |
| SRP064894 | KITLG | 4254 | RNAseq | 0.0618 | 0.8379 | |
| SRP133303 | KITLG | 4254 | RNAseq | -0.0644 | 0.8504 | |
| SRP159526 | KITLG | 4254 | RNAseq | -0.1841 | 0.6685 | |
| SRP193095 | KITLG | 4254 | RNAseq | 0.1876 | 0.3050 | |
| SRP219564 | KITLG | 4254 | RNAseq | -0.1917 | 0.7686 | |
| TCGA | KITLG | 4254 | RNAseq | -0.2047 | 0.0442 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by KITLG expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KITLG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KITLG | 4254 | 3 | 2 | 25 | |
| GSE20123 | KITLG | 4254 | 3 | 2 | 25 | |
| GSE43470 | KITLG | 4254 | 3 | 1 | 39 | |
| GSE46452 | KITLG | 4254 | 9 | 1 | 49 | |
| GSE47630 | KITLG | 4254 | 10 | 1 | 29 | |
| GSE54993 | KITLG | 4254 | 0 | 6 | 64 | |
| GSE54994 | KITLG | 4254 | 7 | 1 | 45 | |
| GSE60625 | KITLG | 4254 | 0 | 0 | 11 | |
| GSE74703 | KITLG | 4254 | 3 | 1 | 32 | |
| GSE74704 | KITLG | 4254 | 1 | 2 | 17 | |
| TCGA | KITLG | 4254 | 19 | 10 | 67 |
Total number of gains: 58; Total number of losses: 27; Total Number of normals: 403.
Somatic mutations of KITLG:
Generating mutation plots.
Highly correlated genes for KITLG:
Showing top 20/226 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KITLG | CASQ1 | 0.764526 | 3 | 0 | 3 |
| KITLG | NKX6-1 | 0.710036 | 3 | 0 | 3 |
| KITLG | ADCYAP1R1 | 0.708205 | 4 | 0 | 3 |
| KITLG | SSPN | 0.698147 | 5 | 0 | 5 |
| KITLG | PCOLCE2 | 0.692841 | 3 | 0 | 3 |
| KITLG | MYOM1 | 0.692436 | 3 | 0 | 3 |
| KITLG | CST5 | 0.68471 | 3 | 0 | 3 |
| KITLG | SMTN | 0.68451 | 4 | 0 | 3 |
| KITLG | BTC | 0.683893 | 3 | 0 | 3 |
| KITLG | CYS1 | 0.676543 | 4 | 0 | 4 |
| KITLG | DNAJC18 | 0.675839 | 3 | 0 | 3 |
| KITLG | MYOC | 0.670278 | 3 | 0 | 3 |
| KITLG | ALPK3 | 0.66863 | 3 | 0 | 3 |
| KITLG | NELL1 | 0.666614 | 3 | 0 | 3 |
| KITLG | FOXN3 | 0.666577 | 4 | 0 | 4 |
| KITLG | KERA | 0.66657 | 3 | 0 | 3 |
| KITLG | HSPB3 | 0.666486 | 4 | 0 | 3 |
| KITLG | RASD2 | 0.663627 | 3 | 0 | 3 |
| KITLG | COL28A1 | 0.663319 | 4 | 0 | 3 |
| KITLG | OBSL1 | 0.662352 | 3 | 0 | 3 |
For details and further investigation, click here
