| Full name: 5-hydroxytryptamine receptor 1D | Alias Symbol: RDC4|HT1DA|5-HT1D | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 3352 | HGNC ID: HGNC:5289 | Ensembl Gene: ENSG00000179546 | OMIM ID: 182133 |
| Drug and gene relationship at DGIdb | |||
HTR1D involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR1D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR1D | 3352 | 207368_at | 0.0526 | 0.8420 | |
| GSE20347 | HTR1D | 3352 | 207368_at | 0.0166 | 0.8169 | |
| GSE23400 | HTR1D | 3352 | 207368_at | -0.0456 | 0.2676 | |
| GSE26886 | HTR1D | 3352 | 207368_at | 0.2178 | 0.0593 | |
| GSE29001 | HTR1D | 3352 | 207368_at | -0.1545 | 0.3521 | |
| GSE38129 | HTR1D | 3352 | 207368_at | -0.0591 | 0.4159 | |
| GSE45670 | HTR1D | 3352 | 207368_at | 0.1232 | 0.1445 | |
| GSE53622 | HTR1D | 3352 | 18032 | 0.2367 | 0.0368 | |
| GSE53624 | HTR1D | 3352 | 18032 | 1.3368 | 0.0000 | |
| GSE63941 | HTR1D | 3352 | 207368_at | 0.3276 | 0.1493 | |
| GSE77861 | HTR1D | 3352 | 207368_at | -0.0168 | 0.8827 | |
| SRP133303 | HTR1D | 3352 | RNAseq | 0.6097 | 0.1233 | |
| TCGA | HTR1D | 3352 | RNAseq | 1.1932 | 0.0129 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HTR1D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR1D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR1D | 3352 | 0 | 5 | 25 | |
| GSE20123 | HTR1D | 3352 | 0 | 4 | 26 | |
| GSE43470 | HTR1D | 3352 | 2 | 6 | 35 | |
| GSE46452 | HTR1D | 3352 | 5 | 1 | 53 | |
| GSE47630 | HTR1D | 3352 | 8 | 3 | 29 | |
| GSE54993 | HTR1D | 3352 | 2 | 1 | 67 | |
| GSE54994 | HTR1D | 3352 | 11 | 4 | 38 | |
| GSE60625 | HTR1D | 3352 | 0 | 0 | 11 | |
| GSE74703 | HTR1D | 3352 | 1 | 4 | 31 | |
| GSE74704 | HTR1D | 3352 | 0 | 0 | 20 | |
| TCGA | HTR1D | 3352 | 9 | 23 | 64 |
Total number of gains: 38; Total number of losses: 51; Total Number of normals: 399.
Somatic mutations of HTR1D:
Generating mutation plots.
Highly correlated genes for HTR1D:
Showing top 20/343 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR1D | ZCCHC12 | 0.732683 | 3 | 0 | 3 |
| HTR1D | ATCAY | 0.71402 | 3 | 0 | 3 |
| HTR1D | TLL2 | 0.713988 | 4 | 0 | 3 |
| HTR1D | SYDE1 | 0.709915 | 3 | 0 | 3 |
| HTR1D | CLDN18 | 0.706172 | 3 | 0 | 3 |
| HTR1D | DNAI2 | 0.704553 | 3 | 0 | 3 |
| HTR1D | RASL10A | 0.697258 | 3 | 0 | 3 |
| HTR1D | PSG3 | 0.69478 | 3 | 0 | 3 |
| HTR1D | TBR1 | 0.680852 | 4 | 0 | 3 |
| HTR1D | CA14 | 0.679047 | 5 | 0 | 4 |
| HTR1D | RHO | 0.675584 | 4 | 0 | 4 |
| HTR1D | ADARB2 | 0.673947 | 3 | 0 | 3 |
| HTR1D | NR1I2 | 0.673834 | 4 | 0 | 4 |
| HTR1D | MIER2 | 0.671154 | 3 | 0 | 3 |
| HTR1D | GLP1R | 0.665583 | 4 | 0 | 4 |
| HTR1D | OLAH | 0.665131 | 3 | 0 | 3 |
| HTR1D | HECTD3 | 0.665082 | 3 | 0 | 3 |
| HTR1D | BTN1A1 | 0.664297 | 4 | 0 | 3 |
| HTR1D | TM4SF5 | 0.663903 | 4 | 0 | 4 |
| HTR1D | AMBN | 0.658871 | 5 | 0 | 4 |
For details and further investigation, click here
