| Full name: tolloid like 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q24.1 | ||
| Entrez ID: 7093 | HGNC ID: HGNC:11844 | Ensembl Gene: ENSG00000095587 | OMIM ID: 606743 |
| Drug and gene relationship at DGIdb | |||
Expression of TLL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLL2 | 7093 | 215843_s_at | -0.0591 | 0.9460 | |
| GSE20347 | TLL2 | 7093 | 215843_s_at | 0.1178 | 0.1314 | |
| GSE23400 | TLL2 | 7093 | 215843_s_at | -0.0644 | 0.2167 | |
| GSE26886 | TLL2 | 7093 | 215843_s_at | 0.5685 | 0.0180 | |
| GSE29001 | TLL2 | 7093 | 215843_s_at | -0.1337 | 0.3720 | |
| GSE38129 | TLL2 | 7093 | 215843_s_at | 0.0584 | 0.5542 | |
| GSE45670 | TLL2 | 7093 | 215843_s_at | 0.3341 | 0.0807 | |
| GSE53622 | TLL2 | 7093 | 120665 | 0.4686 | 0.0031 | |
| GSE53624 | TLL2 | 7093 | 120665 | 0.6469 | 0.0000 | |
| GSE63941 | TLL2 | 7093 | 215843_s_at | 0.5451 | 0.2814 | |
| GSE77861 | TLL2 | 7093 | 215843_s_at | 0.0750 | 0.7022 | |
| SRP064894 | TLL2 | 7093 | RNAseq | -3.5413 | 0.0000 | |
| SRP133303 | TLL2 | 7093 | RNAseq | -0.1486 | 0.3516 | |
| SRP159526 | TLL2 | 7093 | RNAseq | -1.7043 | 0.0000 | |
| SRP193095 | TLL2 | 7093 | RNAseq | -0.7505 | 0.0000 | |
| SRP219564 | TLL2 | 7093 | RNAseq | -2.5412 | 0.0001 | |
| TCGA | TLL2 | 7093 | RNAseq | -0.7373 | 0.0891 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TLL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLL2 | 7093 | 0 | 8 | 22 | |
| GSE20123 | TLL2 | 7093 | 0 | 7 | 23 | |
| GSE43470 | TLL2 | 7093 | 0 | 7 | 36 | |
| GSE46452 | TLL2 | 7093 | 0 | 11 | 48 | |
| GSE47630 | TLL2 | 7093 | 2 | 14 | 24 | |
| GSE54993 | TLL2 | 7093 | 7 | 0 | 63 | |
| GSE54994 | TLL2 | 7093 | 2 | 10 | 41 | |
| GSE60625 | TLL2 | 7093 | 0 | 0 | 11 | |
| GSE74703 | TLL2 | 7093 | 0 | 5 | 31 | |
| GSE74704 | TLL2 | 7093 | 0 | 4 | 16 | |
| TCGA | TLL2 | 7093 | 5 | 28 | 63 |
Total number of gains: 16; Total number of losses: 94; Total Number of normals: 378.
Somatic mutations of TLL2:
Generating mutation plots.
Highly correlated genes for TLL2:
Showing top 20/331 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLL2 | HTR1D | 0.713988 | 4 | 0 | 3 |
| TLL2 | TSHZ3 | 0.693947 | 3 | 0 | 3 |
| TLL2 | SMARCD1 | 0.689682 | 3 | 0 | 3 |
| TLL2 | PI16 | 0.682441 | 3 | 0 | 3 |
| TLL2 | OR51B5 | 0.676535 | 3 | 0 | 3 |
| TLL2 | FNDC8 | 0.669317 | 3 | 0 | 3 |
| TLL2 | KDM6B | 0.668805 | 3 | 0 | 3 |
| TLL2 | LGI2 | 0.666432 | 4 | 0 | 3 |
| TLL2 | CRYGB | 0.663893 | 4 | 0 | 4 |
| TLL2 | LINC01118 | 0.663687 | 4 | 0 | 4 |
| TLL2 | FEV | 0.663665 | 4 | 0 | 4 |
| TLL2 | TCAP | 0.658968 | 4 | 0 | 3 |
| TLL2 | PRKACA | 0.655219 | 4 | 0 | 4 |
| TLL2 | SZT2 | 0.650149 | 4 | 0 | 3 |
| TLL2 | INSM2 | 0.649413 | 3 | 0 | 3 |
| TLL2 | LRCH1 | 0.648637 | 3 | 0 | 3 |
| TLL2 | UBQLN3 | 0.648585 | 3 | 0 | 3 |
| TLL2 | MMP21 | 0.646656 | 3 | 0 | 3 |
| TLL2 | FXYD1 | 0.64581 | 3 | 0 | 3 |
| TLL2 | SPRED3 | 0.640047 | 4 | 0 | 4 |
For details and further investigation, click here
