| Full name: 5-hydroxytryptamine receptor 2A | Alias Symbol: 5-HT2A | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 3356 | HGNC ID: HGNC:5293 | Ensembl Gene: ENSG00000102468 | OMIM ID: 182135 |
| Drug and gene relationship at DGIdb | |||
HTR2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04540 | Gap junction | |
| hsa04726 | Serotonergic synapse | |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of HTR2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR2A | 3356 | 207135_at | -0.3655 | 0.5670 | |
| GSE20347 | HTR2A | 3356 | 207135_at | 0.1681 | 0.1398 | |
| GSE23400 | HTR2A | 3356 | 207135_at | -0.1573 | 0.0002 | |
| GSE26886 | HTR2A | 3356 | 207135_at | 0.0888 | 0.6562 | |
| GSE29001 | HTR2A | 3356 | 207135_at | 0.0940 | 0.5598 | |
| GSE38129 | HTR2A | 3356 | 207135_at | -0.1895 | 0.1256 | |
| GSE45670 | HTR2A | 3356 | 207135_at | -0.4567 | 0.0133 | |
| GSE53622 | HTR2A | 3356 | 66919 | -0.7001 | 0.0005 | |
| GSE53624 | HTR2A | 3356 | 83942 | -0.0497 | 0.7784 | |
| GSE63941 | HTR2A | 3356 | 207135_at | -1.1611 | 0.0004 | |
| GSE77861 | HTR2A | 3356 | 207135_at | 0.0963 | 0.3714 | |
| SRP133303 | HTR2A | 3356 | RNAseq | 0.2972 | 0.1665 | |
| SRP159526 | HTR2A | 3356 | RNAseq | 1.4918 | 0.0580 | |
| SRP193095 | HTR2A | 3356 | RNAseq | 0.2830 | 0.1437 | |
| TCGA | HTR2A | 3356 | RNAseq | -0.9412 | 0.0439 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HTR2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR2A | 3356 | 0 | 14 | 16 | |
| GSE20123 | HTR2A | 3356 | 0 | 13 | 17 | |
| GSE43470 | HTR2A | 3356 | 3 | 13 | 27 | |
| GSE46452 | HTR2A | 3356 | 0 | 33 | 26 | |
| GSE47630 | HTR2A | 3356 | 2 | 27 | 11 | |
| GSE54993 | HTR2A | 3356 | 12 | 2 | 56 | |
| GSE54994 | HTR2A | 3356 | 1 | 16 | 36 | |
| GSE60625 | HTR2A | 3356 | 0 | 3 | 8 | |
| GSE74703 | HTR2A | 3356 | 3 | 10 | 23 | |
| GSE74704 | HTR2A | 3356 | 0 | 10 | 10 | |
| TCGA | HTR2A | 3356 | 8 | 37 | 51 |
Total number of gains: 29; Total number of losses: 178; Total Number of normals: 281.
Somatic mutations of HTR2A:
Generating mutation plots.
Highly correlated genes for HTR2A:
Showing top 20/305 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR2A | ABCA9 | 0.741081 | 3 | 0 | 3 |
| HTR2A | DNM3OS | 0.687181 | 4 | 0 | 4 |
| HTR2A | UBE2D4 | 0.654923 | 4 | 0 | 3 |
| HTR2A | FMO3 | 0.647978 | 3 | 0 | 3 |
| HTR2A | INMT | 0.647592 | 4 | 0 | 4 |
| HTR2A | FIBIN | 0.64388 | 4 | 0 | 4 |
| HTR2A | OLFML1 | 0.643161 | 9 | 0 | 7 |
| HTR2A | ECSCR | 0.642929 | 5 | 0 | 5 |
| HTR2A | CNTN3 | 0.638545 | 3 | 0 | 3 |
| HTR2A | LRRN4CL | 0.630235 | 7 | 0 | 6 |
| HTR2A | CNRIP1 | 0.628024 | 7 | 0 | 6 |
| HTR2A | PAMR1 | 0.627133 | 8 | 0 | 8 |
| HTR2A | CLSTN2 | 0.618629 | 5 | 0 | 4 |
| HTR2A | RXRG | 0.617062 | 4 | 0 | 3 |
| HTR2A | CLC | 0.616294 | 4 | 0 | 3 |
| HTR2A | EBF1 | 0.615475 | 6 | 0 | 5 |
| HTR2A | FAM13C | 0.612954 | 4 | 0 | 3 |
| HTR2A | SERPINA5 | 0.611437 | 6 | 0 | 4 |
| HTR2A | FXYD1 | 0.610786 | 5 | 0 | 5 |
| HTR2A | F5 | 0.608825 | 4 | 0 | 3 |
For details and further investigation, click here
