| Full name: 5-hydroxytryptamine receptor 2B | Alias Symbol: 5-HT(2B)|5-HT2B | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 3357 | HGNC ID: HGNC:5294 | Ensembl Gene: ENSG00000135914 | OMIM ID: 601122 |
| Drug and gene relationship at DGIdb | |||
HTR2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04540 | Gap junction | |
| hsa04726 | Serotonergic synapse | |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of HTR2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR2B | 3357 | 206638_at | -0.7250 | 0.8055 | |
| GSE20347 | HTR2B | 3357 | 206638_at | -0.2495 | 0.4789 | |
| GSE23400 | HTR2B | 3357 | 206638_at | -0.2123 | 0.0934 | |
| GSE26886 | HTR2B | 3357 | 206638_at | 0.1829 | 0.4756 | |
| GSE29001 | HTR2B | 3357 | 206638_at | -0.3613 | 0.1299 | |
| GSE38129 | HTR2B | 3357 | 206638_at | -0.6289 | 0.2104 | |
| GSE45670 | HTR2B | 3357 | 206638_at | -0.7900 | 0.0121 | |
| GSE53622 | HTR2B | 3357 | 101345 | -0.2924 | 0.2652 | |
| GSE53624 | HTR2B | 3357 | 101345 | -0.2115 | 0.2049 | |
| GSE63941 | HTR2B | 3357 | 206638_at | -0.7404 | 0.0938 | |
| GSE77861 | HTR2B | 3357 | 206638_at | 0.0066 | 0.9407 | |
| GSE97050 | HTR2B | 3357 | A_23_P16953 | -0.6025 | 0.3210 | |
| SRP007169 | HTR2B | 3357 | RNAseq | 1.1467 | 0.1445 | |
| SRP133303 | HTR2B | 3357 | RNAseq | 0.8386 | 0.0050 | |
| SRP193095 | HTR2B | 3357 | RNAseq | 0.2558 | 0.1517 | |
| TCGA | HTR2B | 3357 | RNAseq | -0.4595 | 0.1757 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HTR2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR2B | 3357 | 1 | 13 | 16 | |
| GSE20123 | HTR2B | 3357 | 1 | 12 | 17 | |
| GSE43470 | HTR2B | 3357 | 1 | 8 | 34 | |
| GSE46452 | HTR2B | 3357 | 0 | 5 | 54 | |
| GSE47630 | HTR2B | 3357 | 4 | 5 | 31 | |
| GSE54993 | HTR2B | 3357 | 2 | 2 | 66 | |
| GSE54994 | HTR2B | 3357 | 6 | 11 | 36 | |
| GSE60625 | HTR2B | 3357 | 0 | 3 | 8 | |
| GSE74703 | HTR2B | 3357 | 1 | 6 | 29 | |
| GSE74704 | HTR2B | 3357 | 1 | 5 | 14 | |
| TCGA | HTR2B | 3357 | 13 | 27 | 56 |
Total number of gains: 30; Total number of losses: 97; Total Number of normals: 361.
Somatic mutations of HTR2B:
Generating mutation plots.
Highly correlated genes for HTR2B:
Showing top 20/606 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR2B | EBF2 | 0.751022 | 3 | 0 | 3 |
| HTR2B | LINC00702 | 0.732901 | 3 | 0 | 3 |
| HTR2B | SCMH1 | 0.722862 | 5 | 0 | 5 |
| HTR2B | DDX42 | 0.705018 | 3 | 0 | 3 |
| HTR2B | GPM6A | 0.702324 | 9 | 0 | 7 |
| HTR2B | NPY | 0.698631 | 6 | 0 | 5 |
| HTR2B | PCDH9 | 0.697073 | 7 | 0 | 6 |
| HTR2B | ADARB1 | 0.694693 | 7 | 0 | 6 |
| HTR2B | DGKG | 0.694199 | 5 | 0 | 5 |
| HTR2B | SLC35F1 | 0.693237 | 3 | 0 | 3 |
| HTR2B | ITGB1BP2 | 0.688844 | 5 | 0 | 4 |
| HTR2B | SYNC | 0.68774 | 7 | 0 | 6 |
| HTR2B | HABP4 | 0.68433 | 6 | 0 | 6 |
| HTR2B | PDE3A | 0.682688 | 6 | 0 | 5 |
| HTR2B | TMOD1 | 0.682275 | 7 | 0 | 6 |
| HTR2B | TLN1 | 0.681185 | 5 | 0 | 5 |
| HTR2B | WSCD2 | 0.680394 | 5 | 0 | 4 |
| HTR2B | EPM2A | 0.674947 | 6 | 0 | 6 |
| HTR2B | TNFSF12 | 0.674826 | 3 | 0 | 3 |
| HTR2B | BRINP3 | 0.673879 | 6 | 0 | 4 |
For details and further investigation, click here
