| Full name: 5-hydroxytryptamine receptor 2C | Alias Symbol: 5-HT2C|5HTR2C | ||
| Type: protein-coding gene | Cytoband: Xq23 | ||
| Entrez ID: 3358 | HGNC ID: HGNC:5295 | Ensembl Gene: ENSG00000147246 | OMIM ID: 312861 |
| Drug and gene relationship at DGIdb | |||
HTR2C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04540 | Gap junction | |
| hsa04726 | Serotonergic synapse | |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of HTR2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR2C | 3358 | 207307_at | 1.0728 | 0.2966 | |
| GSE20347 | HTR2C | 3358 | 207307_at | 0.7969 | 0.0012 | |
| GSE23400 | HTR2C | 3358 | 207307_at | 0.2128 | 0.0008 | |
| GSE26886 | HTR2C | 3358 | 207307_at | 2.2174 | 0.0001 | |
| GSE29001 | HTR2C | 3358 | 207307_at | 1.1964 | 0.0091 | |
| GSE38129 | HTR2C | 3358 | 207307_at | 0.9408 | 0.0000 | |
| GSE45670 | HTR2C | 3358 | 207307_at | 1.7550 | 0.0154 | |
| GSE53622 | HTR2C | 3358 | 130020 | 2.2538 | 0.0000 | |
| GSE53624 | HTR2C | 3358 | 69167 | 2.7078 | 0.0000 | |
| GSE63941 | HTR2C | 3358 | 207307_at | 2.0319 | 0.1117 | |
| GSE77861 | HTR2C | 3358 | 211479_s_at | 0.0121 | 0.9259 | |
| TCGA | HTR2C | 3358 | RNAseq | 5.8399 | 0.0000 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by HTR2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR2C:
No record found for this gene.
Somatic mutations of HTR2C:
Generating mutation plots.
Highly correlated genes for HTR2C:
Showing top 20/204 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR2C | SENP1 | 0.700909 | 3 | 0 | 3 |
| HTR2C | SIX4 | 0.679102 | 4 | 0 | 4 |
| HTR2C | POU6F2-AS2 | 0.666393 | 5 | 0 | 5 |
| HTR2C | SYCP2 | 0.653807 | 4 | 0 | 3 |
| HTR2C | STAG1 | 0.643856 | 4 | 0 | 3 |
| HTR2C | GNA13 | 0.632094 | 3 | 0 | 3 |
| HTR2C | RUNDC1 | 0.631994 | 4 | 0 | 3 |
| HTR2C | WDR72 | 0.627243 | 6 | 0 | 5 |
| HTR2C | SLC5A12 | 0.626654 | 6 | 0 | 5 |
| HTR2C | FAR2 | 0.625864 | 3 | 0 | 3 |
| HTR2C | GNGT1 | 0.622042 | 4 | 0 | 3 |
| HTR2C | TBC1D32 | 0.621841 | 5 | 0 | 4 |
| HTR2C | ZNF558 | 0.620437 | 4 | 0 | 4 |
| HTR2C | PTH2R | 0.616213 | 5 | 0 | 4 |
| HTR2C | RHBDD2 | 0.61535 | 4 | 0 | 3 |
| HTR2C | MAGEA1 | 0.614562 | 8 | 0 | 7 |
| HTR2C | HOXC9 | 0.612628 | 3 | 0 | 3 |
| HTR2C | ENPEP | 0.604733 | 5 | 0 | 3 |
| HTR2C | TCF24 | 0.604331 | 4 | 0 | 4 |
| HTR2C | IGFBP3 | 0.602058 | 6 | 0 | 5 |
For details and further investigation, click here
