| Full name: insulin like growth factor binding protein 3 | Alias Symbol: IBP3|BP-53 | ||
| Type: protein-coding gene | Cytoband: 7p12.3 | ||
| Entrez ID: 3486 | HGNC ID: HGNC:5472 | Ensembl Gene: ENSG00000146674 | OMIM ID: 146732 |
| Drug and gene relationship at DGIdb | |||
IGFBP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of IGFBP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP3 | 3486 | 210095_s_at | 1.3544 | 0.1935 | |
| GSE20347 | IGFBP3 | 3486 | 210095_s_at | 2.4439 | 0.0000 | |
| GSE23400 | IGFBP3 | 3486 | 210095_s_at | 1.9971 | 0.0000 | |
| GSE26886 | IGFBP3 | 3486 | 210095_s_at | 2.8663 | 0.0001 | |
| GSE29001 | IGFBP3 | 3486 | 210095_s_at | 1.6339 | 0.0288 | |
| GSE38129 | IGFBP3 | 3486 | 210095_s_at | 2.2663 | 0.0000 | |
| GSE45670 | IGFBP3 | 3486 | 210095_s_at | 2.2740 | 0.0003 | |
| GSE53622 | IGFBP3 | 3486 | 99073 | 2.8560 | 0.0000 | |
| GSE53624 | IGFBP3 | 3486 | 6164 | 2.5181 | 0.0000 | |
| GSE63941 | IGFBP3 | 3486 | 210095_s_at | -3.9265 | 0.1108 | |
| GSE77861 | IGFBP3 | 3486 | 210095_s_at | 2.4472 | 0.0160 | |
| GSE97050 | IGFBP3 | 3486 | A_23_P215634 | 1.6595 | 0.0631 | |
| SRP007169 | IGFBP3 | 3486 | RNAseq | 2.1991 | 0.0000 | |
| SRP008496 | IGFBP3 | 3486 | RNAseq | 3.1036 | 0.0000 | |
| SRP064894 | IGFBP3 | 3486 | RNAseq | 2.7638 | 0.0000 | |
| SRP133303 | IGFBP3 | 3486 | RNAseq | 3.2235 | 0.0000 | |
| SRP159526 | IGFBP3 | 3486 | RNAseq | 3.0586 | 0.0000 | |
| SRP193095 | IGFBP3 | 3486 | RNAseq | 3.0084 | 0.0000 | |
| SRP219564 | IGFBP3 | 3486 | RNAseq | 2.3337 | 0.0009 | |
| TCGA | IGFBP3 | 3486 | RNAseq | 0.3299 | 0.0073 |
Upregulated datasets: 16; Downregulated datasets: 0.
Survival by IGFBP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP3 | 3486 | 15 | 0 | 15 | |
| GSE20123 | IGFBP3 | 3486 | 13 | 0 | 17 | |
| GSE43470 | IGFBP3 | 3486 | 4 | 0 | 39 | |
| GSE46452 | IGFBP3 | 3486 | 11 | 1 | 47 | |
| GSE47630 | IGFBP3 | 3486 | 8 | 1 | 31 | |
| GSE54993 | IGFBP3 | 3486 | 0 | 8 | 62 | |
| GSE54994 | IGFBP3 | 3486 | 16 | 3 | 34 | |
| GSE60625 | IGFBP3 | 3486 | 0 | 0 | 11 | |
| GSE74703 | IGFBP3 | 3486 | 4 | 0 | 32 | |
| GSE74704 | IGFBP3 | 3486 | 7 | 0 | 13 | |
| TCGA | IGFBP3 | 3486 | 50 | 7 | 39 |
Total number of gains: 128; Total number of losses: 20; Total Number of normals: 340.
Somatic mutations of IGFBP3:
Generating mutation plots.
Highly correlated genes for IGFBP3:
Showing top 20/1313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP3 | PYCR2 | 0.787345 | 3 | 0 | 3 |
| IGFBP3 | TP53I13 | 0.737983 | 6 | 0 | 6 |
| IGFBP3 | SPON2 | 0.73407 | 3 | 0 | 3 |
| IGFBP3 | ALPK2 | 0.732682 | 3 | 0 | 3 |
| IGFBP3 | FNDC3B | 0.730377 | 11 | 0 | 11 |
| IGFBP3 | PDIA5 | 0.727211 | 3 | 0 | 3 |
| IGFBP3 | CTHRC1 | 0.72647 | 7 | 0 | 7 |
| IGFBP3 | FAM89A | 0.724186 | 3 | 0 | 3 |
| IGFBP3 | GRAMD1A | 0.717278 | 7 | 0 | 7 |
| IGFBP3 | EDIL3 | 0.716082 | 3 | 0 | 3 |
| IGFBP3 | MBNL2 | 0.7118 | 3 | 0 | 3 |
| IGFBP3 | SHISA2 | 0.709098 | 6 | 0 | 6 |
| IGFBP3 | TTYH3 | 0.709071 | 7 | 0 | 6 |
| IGFBP3 | SH3PXD2B | 0.703457 | 7 | 0 | 6 |
| IGFBP3 | SLC19A1 | 0.700722 | 3 | 0 | 3 |
| IGFBP3 | ALKBH6 | 0.697968 | 4 | 0 | 4 |
| IGFBP3 | DNAJB11 | 0.697963 | 6 | 0 | 6 |
| IGFBP3 | CMSS1 | 0.697781 | 5 | 0 | 5 |
| IGFBP3 | TMEM138 | 0.696015 | 6 | 0 | 6 |
| IGFBP3 | ZNF469 | 0.6945 | 7 | 0 | 7 |
For details and further investigation, click here
