HUWE1

 

Full name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Alias Symbol: Ib772|KIAA0312|UREB1
Type: protein-coding gene Cytoband: Xp11.22
Entrez ID: 10075 HGNC ID: HGNC:30892 Ensembl Gene: ENSG00000086758 OMIM ID: 300697
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 146/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HUWE1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HUWE1 10075 207783_x_at -0.1127 0.5344
GSE20347 HUWE1 10075 207783_x_at -0.1282 0.0041
GSE23400 HUWE1 10075 207783_x_at -0.1175 0.0000
GSE26886 HUWE1 10075 207783_x_at -0.1468 0.0618
GSE29001 HUWE1 10075 207783_x_at -0.1524 0.0988
GSE38129 HUWE1 10075 207783_x_at -0.1459 0.0000
GSE45670 HUWE1 10075 207783_x_at -0.0757 0.1442
GSE53622 HUWE1 10075 77765 -0.0793 0.1898
GSE53624 HUWE1 10075 77765 0.0481 0.3851
GSE63941 HUWE1 10075 207783_x_at -0.3278 0.0324
GSE77861 HUWE1 10075 207783_x_at -0.1177 0.1948
GSE97050 HUWE1 10075 A_24_P932016 0.1798 0.7099
SRP007169 HUWE1 10075 RNAseq 1.4523 0.0010
SRP008496 HUWE1 10075 RNAseq 1.1275 0.0006
SRP064894 HUWE1 10075 RNAseq 0.0203 0.9204
SRP133303 HUWE1 10075 RNAseq 0.0419 0.8524
SRP159526 HUWE1 10075 RNAseq 0.1960 0.3451
SRP193095 HUWE1 10075 RNAseq 0.1723 0.1648
SRP219564 HUWE1 10075 RNAseq 0.1121 0.7433
TCGA HUWE1 10075 RNAseq -0.0532 0.1644

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by HUWE1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HUWE1:

 

No record found for this gene.

 

Somatic mutations of HUWE1:

 

Generating mutation plots.

 

Highly correlated genes for HUWE1:

 

Showing top 20/503 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HUWE1SEMA6A0.701554303
HUWE1HNRNPA30.668659303
HUWE1IMPA10.666821303
HUWE1MRPS360.656341404
HUWE1DIMT10.652022303
HUWE1RNF2080.647833504
HUWE1ZMYM20.646287403
HUWE1BRWD30.642196303
HUWE1HEXIM10.639039303
HUWE1CD630.636412403
HUWE1ZNF5640.636204303
HUWE1NSG10.633221504
HUWE1FHL50.632975303
HUWE1POLR1D0.631944504
HUWE1MRPS250.629698303
HUWE1RASA30.627416303
HUWE1MRGPRF0.626584303
HUWE1FAM107A0.62564403
HUWE1UBA30.624868404
HUWE1DVL10.624216303

For details and further investigation, click here