| Full name: ubiquitin like modifier activating enzyme 3 | Alias Symbol: hUba3|NAE2 | ||
| Type: protein-coding gene | Cytoband: 3p14.1 | ||
| Entrez ID: 9039 | HGNC ID: HGNC:12470 | Ensembl Gene: ENSG00000144744 | OMIM ID: 603172 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UBA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBA3 | 9039 | 209115_at | -0.3150 | 0.2567 | |
| GSE20347 | UBA3 | 9039 | 209115_at | -0.5340 | 0.0033 | |
| GSE23400 | UBA3 | 9039 | 209115_at | -0.2341 | 0.0017 | |
| GSE26886 | UBA3 | 9039 | 209115_at | -0.8644 | 0.0000 | |
| GSE29001 | UBA3 | 9039 | 209115_at | -0.4236 | 0.2278 | |
| GSE38129 | UBA3 | 9039 | 209115_at | -0.4582 | 0.0001 | |
| GSE45670 | UBA3 | 9039 | 209115_at | -0.2653 | 0.0396 | |
| GSE53622 | UBA3 | 9039 | 75397 | -0.2220 | 0.0001 | |
| GSE53624 | UBA3 | 9039 | 75397 | -0.5262 | 0.0000 | |
| GSE63941 | UBA3 | 9039 | 209115_at | -0.6336 | 0.0949 | |
| GSE77861 | UBA3 | 9039 | 209115_at | -0.4951 | 0.2006 | |
| GSE97050 | UBA3 | 9039 | A_23_P211840 | 0.1330 | 0.5115 | |
| SRP007169 | UBA3 | 9039 | RNAseq | -1.2871 | 0.0008 | |
| SRP008496 | UBA3 | 9039 | RNAseq | -0.9358 | 0.0000 | |
| SRP064894 | UBA3 | 9039 | RNAseq | -0.5643 | 0.0019 | |
| SRP133303 | UBA3 | 9039 | RNAseq | -0.2321 | 0.1419 | |
| SRP159526 | UBA3 | 9039 | RNAseq | -0.7490 | 0.0001 | |
| SRP193095 | UBA3 | 9039 | RNAseq | -0.6235 | 0.0000 | |
| SRP219564 | UBA3 | 9039 | RNAseq | -0.8982 | 0.0001 | |
| TCGA | UBA3 | 9039 | RNAseq | -0.0420 | 0.3976 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by UBA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBA3 | 9039 | 1 | 19 | 10 | |
| GSE20123 | UBA3 | 9039 | 1 | 19 | 10 | |
| GSE43470 | UBA3 | 9039 | 0 | 20 | 23 | |
| GSE46452 | UBA3 | 9039 | 2 | 17 | 40 | |
| GSE47630 | UBA3 | 9039 | 1 | 23 | 16 | |
| GSE54993 | UBA3 | 9039 | 5 | 3 | 62 | |
| GSE54994 | UBA3 | 9039 | 1 | 33 | 19 | |
| GSE60625 | UBA3 | 9039 | 3 | 1 | 7 | |
| GSE74703 | UBA3 | 9039 | 0 | 16 | 20 | |
| GSE74704 | UBA3 | 9039 | 1 | 13 | 6 | |
| TCGA | UBA3 | 9039 | 0 | 79 | 17 |
Total number of gains: 15; Total number of losses: 243; Total Number of normals: 230.
Somatic mutations of UBA3:
Generating mutation plots.
Highly correlated genes for UBA3:
Showing top 20/1156 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBA3 | RWDD2B | 0.837231 | 3 | 0 | 3 |
| UBA3 | SARNP | 0.815984 | 3 | 0 | 3 |
| UBA3 | UNC5CL | 0.789419 | 3 | 0 | 3 |
| UBA3 | SYTL4 | 0.786712 | 3 | 0 | 3 |
| UBA3 | IER3IP1 | 0.772869 | 3 | 0 | 3 |
| UBA3 | ZNF416 | 0.77187 | 3 | 0 | 3 |
| UBA3 | HECW2 | 0.75124 | 3 | 0 | 3 |
| UBA3 | CCDC25 | 0.74838 | 3 | 0 | 3 |
| UBA3 | HDHD2 | 0.738985 | 4 | 0 | 4 |
| UBA3 | MTA3 | 0.737918 | 4 | 0 | 4 |
| UBA3 | NDUFA10 | 0.734661 | 4 | 0 | 3 |
| UBA3 | NUP54 | 0.731175 | 3 | 0 | 3 |
| UBA3 | METTL14 | 0.730787 | 4 | 0 | 4 |
| UBA3 | RAB21 | 0.727361 | 4 | 0 | 3 |
| UBA3 | RCOR1 | 0.726732 | 4 | 0 | 3 |
| UBA3 | SACM1L | 0.720641 | 12 | 0 | 11 |
| UBA3 | A2ML1 | 0.716293 | 5 | 0 | 5 |
| UBA3 | NAA35 | 0.710323 | 4 | 0 | 3 |
| UBA3 | LYSMD3 | 0.709936 | 5 | 0 | 5 |
| UBA3 | THOC7 | 0.709893 | 12 | 0 | 11 |
For details and further investigation, click here
