| Full name: RAS p21 protein activator 3 | Alias Symbol: GAP1IP4BP|GAPIII | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 22821 | HGNC ID: HGNC:20331 | Ensembl Gene: ENSG00000185989 | OMIM ID: 605182 |
| Drug and gene relationship at DGIdb | |||
RASA3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of RASA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASA3 | 22821 | 225562_at | 0.1287 | 0.8109 | |
| GSE20347 | RASA3 | 22821 | 206220_s_at | 0.0835 | 0.4863 | |
| GSE23400 | RASA3 | 22821 | 206220_s_at | -0.0726 | 0.0219 | |
| GSE26886 | RASA3 | 22821 | 225562_at | 1.2372 | 0.0001 | |
| GSE29001 | RASA3 | 22821 | 206220_s_at | -0.1040 | 0.5091 | |
| GSE38129 | RASA3 | 22821 | 206220_s_at | -0.0827 | 0.3267 | |
| GSE45670 | RASA3 | 22821 | 225562_at | -0.2305 | 0.3362 | |
| GSE53622 | RASA3 | 22821 | 134687 | 0.2818 | 0.0020 | |
| GSE53624 | RASA3 | 22821 | 134687 | 0.4267 | 0.0000 | |
| GSE63941 | RASA3 | 22821 | 225562_at | -2.9207 | 0.0001 | |
| GSE77861 | RASA3 | 22821 | 206220_s_at | -0.0285 | 0.8345 | |
| GSE97050 | RASA3 | 22821 | A_33_P3262515 | 0.2955 | 0.1756 | |
| SRP007169 | RASA3 | 22821 | RNAseq | 3.2809 | 0.0000 | |
| SRP008496 | RASA3 | 22821 | RNAseq | 3.9503 | 0.0000 | |
| SRP064894 | RASA3 | 22821 | RNAseq | 0.7202 | 0.0050 | |
| SRP133303 | RASA3 | 22821 | RNAseq | 0.0385 | 0.8812 | |
| SRP159526 | RASA3 | 22821 | RNAseq | 0.0995 | 0.8370 | |
| SRP193095 | RASA3 | 22821 | RNAseq | 1.3066 | 0.0001 | |
| SRP219564 | RASA3 | 22821 | RNAseq | 1.4046 | 0.0328 | |
| TCGA | RASA3 | 22821 | RNAseq | -0.1876 | 0.1282 |
Upregulated datasets: 5; Downregulated datasets: 1.
Survival by RASA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASA3 | 22821 | 6 | 12 | 12 | |
| GSE20123 | RASA3 | 22821 | 6 | 11 | 13 | |
| GSE43470 | RASA3 | 22821 | 4 | 13 | 26 | |
| GSE46452 | RASA3 | 22821 | 3 | 31 | 25 | |
| GSE47630 | RASA3 | 22821 | 3 | 26 | 11 | |
| GSE54993 | RASA3 | 22821 | 12 | 3 | 55 | |
| GSE54994 | RASA3 | 22821 | 9 | 10 | 34 | |
| GSE60625 | RASA3 | 22821 | 0 | 3 | 8 | |
| GSE74703 | RASA3 | 22821 | 3 | 10 | 23 | |
| GSE74704 | RASA3 | 22821 | 4 | 9 | 7 | |
| TCGA | RASA3 | 22821 | 19 | 32 | 45 |
Total number of gains: 69; Total number of losses: 160; Total Number of normals: 259.
Somatic mutations of RASA3:
Generating mutation plots.
Highly correlated genes for RASA3:
Showing top 20/662 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASA3 | TUBG2 | 0.779244 | 3 | 0 | 3 |
| RASA3 | S1PR1 | 0.755844 | 3 | 0 | 3 |
| RASA3 | IFITM1 | 0.746616 | 3 | 0 | 3 |
| RASA3 | SH3RF3 | 0.734629 | 5 | 0 | 5 |
| RASA3 | ADAMTS1 | 0.727913 | 3 | 0 | 3 |
| RASA3 | PCBP3 | 0.723627 | 3 | 0 | 3 |
| RASA3 | C11orf96 | 0.718169 | 4 | 0 | 4 |
| RASA3 | SLC45A1 | 0.712547 | 3 | 0 | 3 |
| RASA3 | KIAA2013 | 0.71186 | 3 | 0 | 3 |
| RASA3 | NNMT | 0.706514 | 3 | 0 | 3 |
| RASA3 | A1BG | 0.701919 | 4 | 0 | 4 |
| RASA3 | SYNC | 0.699393 | 3 | 0 | 3 |
| RASA3 | MCAM | 0.69521 | 5 | 0 | 5 |
| RASA3 | BICC1 | 0.694327 | 6 | 0 | 6 |
| RASA3 | DOCK11 | 0.694202 | 5 | 0 | 5 |
| RASA3 | MTNR1B | 0.691608 | 3 | 0 | 3 |
| RASA3 | SF3A2 | 0.688444 | 3 | 0 | 3 |
| RASA3 | EFEMP2 | 0.688284 | 8 | 0 | 7 |
| RASA3 | TEK | 0.688016 | 3 | 0 | 3 |
| RASA3 | C1R | 0.687681 | 7 | 0 | 7 |
For details and further investigation, click here
